Urethral reconstruction with autologous vein graft: an experimental study

Kahveci, Ramazan; Kahveci, Zeynep; Sırmalı, Şahin; ̈zcan, M. O

doi:10.1016/0007-1226(95)90127-2

Cited by 28 publications

(19 citation statements)

References 6 publications

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“…The autologous veins, including saphenous, external, or internal jugular veins, have been used for urethroplasty. Tuffer performed the urethral reconstruction using vein graft for the first time in 1910 [16] ; subsequently, several animal trials have been performed using vein grafts for urethral reconstruction [21][22][23] . However, the outcomes of the studies were not satisfactory and this may be caused due to the shortcomings of materials and instruments at that time and due to the early removal of the grafts from the donor site before excising the urethra, leading to graft devitalization.…”

Section: Discussionmentioning

confidence: 99%

Urethral Reconstruction Using Everted Saphenous Vein Graft in a Rabbit Model: One-Year Outcomes

Xu¹,

Shen

Liu

et al. 2017

Urol Int

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Objective: To investigate the efficacy of using everted saphenous vein graft for urethral reconstruction. Materials and Methods: Thirty-five adult male rabbits were divided into 7 groups randomly: experimental group A, B, C, D, E, stricture control group and normal control group (n = 5). In experimental groups and the stricture control group, a urethral mucosa defect (1.5 × 0.8 cm) was created in each rabbit. In experimental groups, a 2-cm long saphenous vein graft was harvested and incised longitudinally and urethral reconstruction was carried out using the everted saphenous vein patch. Rabbits in experimental group A-E were killed respectively at 1 week, 2 weeks, 1 month, 3 months, and 1 year postoperatively, and the specimens were obtained for histo-pathological examination. Retrograde urethrography was performed to evaluate urethral patency before sacrifice in group D and the stricture control group. Results: In the histo-pathological study, the vein grafts were visible within first week. The vein graft was completely covered by epithelium 1 month postoperatively. Retrograde urethrograms showed the urethral caliber of experimental rabbits were similar to those of normal. While the stricture control group showed a narrow urethral lumen and urothelium defect. Conclusions: For urethral reconstruction, everted saphenous vein graft can be an ideal substitute material because of its longer survival time and rapid epithelization capacity.

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Section: Discussionmentioning

confidence: 99%

Urethral Reconstruction Using Everted Saphenous Vein Graft in a Rabbit Model: One-Year Outcomes

Xu¹,

Shen

Liu

et al. 2017

Urol Int

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“…Any loss of the graft could result in recurrent stricture and increase scar tissues. [4,7,8,16,17] The advantage of using a flap for urethral reconstruction is that viability does not depend on the quality of the recipient bed. [7][8][9]12,16,17] In addition, the superiority of skin flaps to skin graft is obvious for the resurfacing of a large or a denuded penile shaft.…”

Section: Discussionmentioning

confidence: 99%

“…Urethral reconstruction using tube-shaped skin grafts or flaps are not always successful because of postoperative complications such as infection, hair growth, fistula, stone formation, diverticula, and strictures. [4,12,[15][16][17] Figure 2. (a, b) The reconstructed penis.…”

Section: Discussionmentioning

confidence: 99%

“…Various graft materials such as genital or extra genital skin or mucosa have been used for establishing a normal urethral lumen, [1][2][3][4][5] or split-thickness skin grafts used for coverage of a denuded penile shaft. [6] Local pedicled penile or scrotal flaps and pedicled regional flaps have allowed reliable long-term results to create a solution to long urethral defects and resurfacing of large penile skin defects.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Repair of complex penile defect with composite anterolateral thigh and vascularized fascia lata flap

Yazar

Eroğlu

Gökkaya

et al. 2015

Ulus Travma Acil Cerrahi Derg

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One-stage reconstruction of complex penile defects with functional and cosmetic results is a challenging procedure. The selection of proper technique and materials for reconstruction depends on the type of the deficient tissue components, the size of the wound surface, and the donor site. This article presented a case of a partial penile and urethral defect due to an infection in the previous surgical site. The patient was treated with a perforator based pedicled composite anterolateral thigh flap combined with vascularized fascia lata. The urethral defect was reconstructed with the vascularized fascia lata. The remaining part of the flap was used for the resurfacing of the right cavernous body and penile skin defect. There was no fistula and the urinary caliber was accepted as good. The pedicled composite anterolateral thigh flap contains various tissue components suitable for a functional and cosmetic reconstruction of complex penile defects using the one-stage technique.

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“…The use of tunica vaginalis is now for coverage purposes, to protect the reconstructed area. Another tissue was used for an experimental study, the use of autologous vein graft on the rabbit model without strong conclusions (Kahveci et al 1995). More recently, colonic mucosa has been suggested for the urethral replacement in case of long and complex stricture.…”

Section: Tissue Engineering 490mentioning

confidence: 99%