Uric acid and fibrinogen: age-modulated relationships with blood pressure components

Leite, Maria Léa Corrêa

doi:10.1038/jhh.2010.89

Cited by 17 publications

(5 citation statements)

References 49 publications

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“… 23 Likewise, higher BP even within normal range was verified to be associated with a higher risk of other metabolic disorders, which include diabetes, osteoporosis and hyperuricemia. 24 – 27 These studies may suggest that the “normal BP” may be not the real normal as we have previously considered, especially when targeted to special diseases, such as NAFLD. 22 , 23 …”

Section: Discussionmentioning

confidence: 90%

Increased Levels of Systolic Blood Pressure Within the Normal Range Are Associated With Significantly Elevated Risks of Nonalcoholic Fatty Liver Disease

Zou

Zhu

et al. 2015

Medicine

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A positive association between hypertension or high-normal blood pressure (BP) and risk of nonalcoholic fatty liver disease (NAFLD) is well-known; however, no data have been generated exploring the risk of NAFLD within the normal range of BP. We aimed to assess the association between normal systolic blood pressure (SBP) and risk of NAFLD.A total of 27,769 subjects from 2 separate medical centers were included. Subjects were divided into 4 groups (G1 to G4) by SBP levels: G1: 90–99 mmHg, G2: 100–109 mmHg, G3: 110–119 mmHg, and G4: 120–129 mmHg. The prevalence, hazard ratios (HRs) and 95% confidence intervals (CIs) for NAFLD were calculated across each group, using the G1 as reference.Higher SBP was observed in subjects with NAFLD than those without NAFLD. The prevalence of NAFLD in a cross-sectional population from G1 to G4 was 6.1%, 13.6%, 19.6%, and 25.8%, respectively. The HRs for NAFLD in the longitudinal population were 2.17 (95% CI 1.60–2.93), 3.87 (95% CI 2.89–5.16), 5.81 (95% CI 4.32–7.81) for G2, G3, and G4, respectively. After adjusting for known confounding variables, HRs of G2 to G4 were 1.44 (95% CI 1.06–1.96), 1.94 (95% CI 1.44–2.61), 2.38 (95% CI 1.75–3.23), respectively.This is the first study to demonstrate that increased levels of SBP within the normal range are associated with significantly elevated risks of NAFLD, independent of other confounding factors.

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Section: Discussionmentioning

confidence: 90%

Increased Levels of Systolic Blood Pressure Within the Normal Range Are Associated With Significantly Elevated Risks of Nonalcoholic Fatty Liver Disease

Zou

Zhu

et al. 2015

Medicine

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“…More specifically, plasma uric acid levels significantly predict diastolic hypertension, but not systolic hypertension (35, 36). However, this association decreases as patients age (37) and is not found in elderly patients (36, 38-40). The weakening relationship between uric acid and hypertension with age has a few possible explanations.…”

Section: Uric Acid and Hypertensionmentioning

confidence: 99%

Uric acid, hyperuricemia and vascular diseases

et al. 2012

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Uric acid is the product of purine metabolism. It is known that hyperuricemia, defined as high levels of blood uric acid, is the major etiological factor of gout. A number of epidemiological reports have increasingly linked hyperuricemia with cardiovascular and neurological diseases. Studies highlighting the pathogenic mechanisms of uric acid point to an inflammatory response as the primary mechanism for inducing gout and possibly contributing to uric acid's vascular effects. Monosodium urate (MSU) crystals induce an inflammatory reaction, which are recognized by Toll-like receptors (TLRs). These TLRs then activate NALP3 inflammasome. MSU also triggers neutrophil activation and further produces immune mediators, which lead to a proinflammatory response. In addition, soluble uric acid can also mediate the generation of free radicals and function as a pro-oxidant. This review summarizes the epidemiological studies of hyperuricemia and cardiovascular disease, takes a brief look at hyperuricemia and its role in neurological diseases, and highlights the studies of the advanced pathological mechanisms of uric acid and inflammation.

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“…Furthermore, it has been demonstrated that high plasma uric acid levels are positively associated with increased incidences of hypertension in adults (Chu et al 2000). More specifically, plasma uric acid levels significantly predict diastolic hypertension, but not systolic hypertension (Leite 2011). A relationship between elevated UA concentration in plasma and the occurrence of hypertension has been very well documented in many clinical and epidemiological studies (Messerli et al 1980, Nagahama et al 2004, Alper et al 2005, Sundstrom et al 2005.…”

Section: Introductionmentioning

confidence: 97%

Uridine – An Indicator of Post-Exercise Uric Acid Concentration and Blood Pressure

Dudzińska

Lubkowska²,

Dołęgowska³

et al. 2015

Physiol Res

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Studies have shown that uridine concentration in plasma may be an indicator of uric acid production in patients with gout. It has been also postulated that uridine takes part in blood pressure regulation. Since physical exercise is an effective tool in treatment and prevention of cardio-vascular diseases that are often accompanied by hyperuricemia and hypertension, it seemed advisable to attempt to evaluate the relationship between oxypurine concentrations (Hyp, Xan and UA) and that of Urd and BP after physical exercise in healthy subjects. Sixty healthy men (17.2±1.71 years, BMI 23.2±2.31 kg m −2 , VO 2max 54.7±6.48 ml kg −1 min −1 ) took part in the study. The subjects performed a single maximal physical exercise on a bicycle ergometer. Blood for analyses was sampled three times: immediately before exercise, immediately after exercise, and in the 30th min of rest. Concentrations of uridine and hypoxanthine, xanthine and uric acid were determined in whole blood using high-performance liquid chromatography. We have shown in this study that the maximal exercise-induced increase of uridine concentration correlates with the post-exercise increase of uric acid concentration and systolic blood pressure. The results of our study show a relationship between uridine concentration in blood and uric acid concentration and blood pressure. We have been the first to demonstrate that a maximal exercise-induced increase in uridine concentration is correlated with the post-exercise and recovery-continued increase of uric acid concentration in healthy subjects. Thus, it appears that uridine may be an indicator of post-exercise hyperuricemia and blood pressure.

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Uric acid and fibrinogen: age-modulated relationships with blood pressure components

Cited by 17 publications

References 49 publications

Increased Levels of Systolic Blood Pressure Within the Normal Range Are Associated With Significantly Elevated Risks of Nonalcoholic Fatty Liver Disease

Increased Levels of Systolic Blood Pressure Within the Normal Range Are Associated With Significantly Elevated Risks of Nonalcoholic Fatty Liver Disease

Uric acid, hyperuricemia and vascular diseases

Uridine – An Indicator of Post-Exercise Uric Acid Concentration and Blood Pressure

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