Uric acid in plants and microorganisms: Biological applications and genetics - A review

Hafez, Rehab M.; Abdelrahman, Tarig; Naguib, Rasha M.

doi:10.1016/j.jare.2017.05.003

Cited by 81 publications

(56 citation statements)

References 116 publications

(146 reference statements)

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“…Purines naturally occur in all plant foods. It was found that at least 10–15 mg of purine per 100 g of food is present in all plant foods, with most plant foods containing low or moderate concentrations [81]. The purine content in animal sources (e.g., meat and fish) generally varies from approximately 120 to over 400 mg of purine per 100 g, while the purine content in plant sources (e.g., most nonsoy legumes, grains, seeds, fruits, and other vegetables) varies from 7 to 70 mg of purine per 100 g [47].…”

Section: Purine Content Of Pbd Lifestyle May Not Be An Unavoidablementioning

confidence: 99%

Uric Acid and Plant-Based Nutrition

Jakše

Pajek

et al. 2019

Nutrients

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Plant-based diets (PBDs) are associated with decreased risk of morbidity and mortality associated with important noncommunicable chronic diseases. Similar to animal-based food sources (e.g., meat, fish, and animal visceral organs), some plant-based food sources (e.g., certain soy legume products, sea vegetables, and brassica vegetables) also contain a high purine load. Suboptimally designed PBDs might consequently be associated with increased uric acid levels and gout development. Here, we review the available data on this topic, with a great majority of studies showing reduced risk of hyperuricemia and gout with vegetarian (especially lacto-vegetarian) PBDs. Additionally, type of ingested purines, fiber, vitamin C, and certain lifestyle factors work in concordance to reduce uric acid generation in PBDs. Recent limited data show that even with an exclusive PBD, uric acid concentrations remain in the normal range in short- and long-term dieters. The reasonable consumption of plant foods with a higher purine content as a part of PBDs may therefore be safely tolerated in normouricemic individuals, but additional data is needed in hyperuricemic individuals, especially those with chronic kidney disease.

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Section: Purine Content Of Pbd Lifestyle May Not Be An Unavoidablementioning

confidence: 99%

Uric Acid and Plant-Based Nutrition

Jakše

Pajek

et al. 2019

Nutrients

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“…Purines are part of nitrogen metabolism and include molecules such as adenine, guanine, hypoxanthine, xanthine and uric acid, among others. The purine pathway allows the recycling of the end products (glyoxylate and ammonia) to synthesize new organic compounds necessary to plant growth (Theimer and Beevers ; Nguyen ; Werner and Witte ; Hafez et al ). Moreover, purine metabolism has also been associated with the mechanism of response to environmental stresses such as drought tolerance (Stasolla et al ; Watanabe et al ; Irani and Todd ).…”

Section: Peroxisomal Uric Acid Metabolism With Dual Functions: Generamentioning

confidence: 99%

Plant peroxisomes at the crossroad of NO and H₂O₂ metabolism

Corpas

Rı́o

Palma

2019

JIPB

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Plant peroxisomes are subcellular compartments involved in many biochemical pathways during the life cycle of a plant but also in the mechanism of response against adverse environmental conditions. These organelles have an active nitro-oxidative metabolism under physiological conditions but this could be exacerbated under stress situations. Furthermore, peroxisomes have the capacity to proliferateand also undergo biochemical adaptations depending on the surrounding cellular status. An important characteristic of peroxisomes is that they have a dynamic metabolism of reactive nitrogen and oxygen species (RNS and ROS) which generates two key molecules, nitric oxide (NO) and hydrogen peroxide (H 2 O 2 ). These molecules can exert signaling functions by means of post-translational modifications that affect the functionality of target molecules like proteins, peptides or fatty acids. This review provides an overview of the endogenous metabolism of ROS and RNS in peroxisomes with special emphasis on polyamine and uric acid metabolism as well as the possibility that these organelles could be a source of signal molecules involved in the functional interconnection with other subcellular compartments.

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“…The second step is the conversion of hypoxanthine into xanthine and then to uric acid by the enzyme xanthine oxidoreductase (XOR) that occurs in two isoforms: the xanthine dehydrogenase (XDH) and the xanthine oxidase (XO). The third step consists of three major enzymatic reactions: (i) the oxidation of the uric acid to 5-hydroxyisourate (HIU) via a coenzymeindependent enzyme urate oxidase (UOX), also known as uricase, in a two stage-oxidation followed by hydration-in B. subtilis and B. fastidiosus (Wei et al 2016); (ii) the conversion of HIU to 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate (OHCU) catalyzed by the putative xanthine upregulated transthyretin-related proteins 5-hydroxyisourate hydrolase as in Escherichia coli (Urano et al 2015); and, (iii) the stereoselective decarboxylation of OHCU to the Virgilia oroboides Paraburkholderia kirstenboschensis (Steenkamp et al 2015) dextrorotatory (S)-allantoin catalyzed by the enzyme OHCU decarboxylase in, i.e., B. subtilis, E. coli, Herbaspirillum seropedicae, Klebsiella spp., and Ruegeria pomeroyi TB-90 (Matiollo et al 2009;Doniselli et al 2015;Cunliffe 2016;Hafez et al 2017). The fourth step underlies the conversion of (S)allantoin into allantoate by the enzyme (S)-allantoin amidohydrolase (allantoinase) (Werner and Witte 2011).…”

Section: Bacterial Ureide Synthesismentioning

confidence: 99%

Ureide metabolism in plant-associated bacteria: purine plant-bacteria interactive scenarios under nitrogen deficiency

Izaguirre‐Mayoral

Lazarovits²,

Baral

2018

Plant Soil

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Background The erratic alterations in climate being experienced in agriculture, such as extended periods of drought or heavy rainfalls, are bringing increasing concerns about nitrogen (N) management. Even in highinput farming systems, unpredictable weather patterns can cause N deficiencies and result in nutrient losses that contribute to major pollution issues in groundwater, lakes, and even the oceans. Our present understanding of the beneficial interactions between N-deficientchallenged plants and plant-associated bacteria (PAB), mainly of the phyla Actinobacteria, Bacteroidetes, Firmicutes, and Proteobacteria, is largely based on

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Uric acid in plants and microorganisms: Biological applications and genetics - A review

Abstract: Graphical abstract

Cited by 81 publications

References 116 publications

Uric Acid and Plant-Based Nutrition

Uric Acid and Plant-Based Nutrition

Plant peroxisomes at the crossroad of NO and H₂O₂ metabolism

Ureide metabolism in plant-associated bacteria: purine plant-bacteria interactive scenarios under nitrogen deficiency

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Uric acid in plants and microorganisms: Biological applications and genetics - A review

Abstract: Graphical abstract

Cited by 81 publications

References 116 publications

Uric Acid and Plant-Based Nutrition

Uric Acid and Plant-Based Nutrition

Plant peroxisomes at the crossroad of NO and H2O2 metabolism

Ureide metabolism in plant-associated bacteria: purine plant-bacteria interactive scenarios under nitrogen deficiency

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Plant peroxisomes at the crossroad of NO and H₂O₂ metabolism