Uric Acid to High-Density Lipoprotein Cholesterol Ratio is a Novel Marker to Predict Functionally Significant Coronary Artery Stenosis

Abstract

Background. Intermediate coronary stenosis (ICS) is defined as a visually estimated percentage of diameter stenosis ranging between 40% and 70% by conventional coronary angiography (CAG). Whether to perform percutaneous coronary intervention (PCI) for these lesions is a challenge in clinical practice. The fractional flow reserve (FFR) can guide treatment by determining the functional significance of ICS. Studies have shown that some clinical indicators can be used to predict FFR. However, there is little research on this in the Chinese population. Methods. We retrospectively analyzed 690 patients who underwent FFR measurements to determine the functional significance of a single ICS. Patients were divided into 2 groups: FFR ≤0.8 (n = 280) and FFR >0.8 (n = 410). We compared the clinical factors between the two groups and performed multivariate logistic regression analyses to explore the risk factors. In addition, receiver-operating characteristic (ROC) curves were constructed for FFR ≤0.8 diagnoses. Results. The mean UHR (uric acid to high-density lipoprotein cholesterol ratio) level was significantly higher in the FFR ≤0.8 group ( p < 0.001 ). UHR corrects negatively with FFR (r = −0.44, p < 0.001 ). High-level UHR was an independent risk factor for the FFR ≤0.8 (OR = 7.17, 95% CI 4.17–12.34). The area under the curve (AUC) of the UHR diagnostic capacity for the FFR ≤0.8 is 0.77, with 77.3% sensitivity and 68.2% specificity. Conclusion. UHR levels were significantly increased in patients with hemodynamically significant coronary lesions. UHR is a novel predictor of functionally significant lesions in patients with a single-vessel disease of ICS.

Uric acid/HDL-C Ratio May Predict Significant Coronary Artery Stenosis: Intravascular Ultrasonography Study

“…Other studies have also shown that the UA value and modi cation of some lipid biomarkers could predict the FFR value [6,20]. In a recent study by Fanqi Li et al, a signi cant relationship was determined between UHR and FFR severity in patients with ICS [21]. All of these studies concentrated on the functional signi cance of the stricture and were conducted with the FFR test.…”

Serum Uric Acid to High‑density Lipoprotein Cholesterol Ratio is Associated with Visceral Fat in Patients with Type 2 Diabetes

“… 18 Another retrospective study in a Chinese population reported that the UHR as a novel marker is significantly increased in patients with coronary lesions. 19 A study in Turkey reported that UHR is a strong predictor of metabolic syndrome in patients with diabetes. 20 Additional research has shown that UHR is significantly associated with nonalcoholic fatty liver disease and may serve as a novel and reliable marker for nonalcoholic fatty liver disease in lean Chinese adults.…”

Triglyceride to high-density lipoprotein cholesterol ratio associated with long-term adverse clinical outcomes in patients deferred revascularization following fractional flow reserve

“…This study retrospectively included 1500 consecutive participants who received FFR and CAG for coronary intermediate lesions from February 2013 to October 2021, the same as the previous study population [ 7 ]. The study design was approved and performed in Beijing Anzhen Hospital, which is a major referral center dedicated to cardiovascular disease.…”