Uric acid to high-density lipoprotein cholesterol ratio predicts cardiovascular mortality in patients on peritoneal dialysis

Liu, Ruihua; Peng, Yuan; Wu, Haishan; Diao, Xiangwen; Ye, Hongjian; Huang, Xuan; Chen, Yi; Mao, Haiping; Huang, Fengxian; Yu, Xueqing; Yang, Xiao

doi:10.1016/j.numecd.2020.10.005

Cited by 33 publications

(23 citation statements)

References 40 publications

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“…There were numerous studies in the literature evaluating uric acid and HDL concurrently. Except for the study conducted by Liu et al, a ratio-based result such as the UHR that predicts CV risk in patients with CKD receiving renal replacement therapy has not been notified yet (17). Per the current findings, our study determined increases in non-dipper BP, nocturnal HR, and nocturnal diastolic BP results in hemodialysis patients with high UHR.…”

Section: Discussionsupporting

confidence: 48%

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Hemodiyaliz Hastalarında Yüksek Serum Ürik Asit/HDL-Kolesterol Oranı Kardiyovasküler Risk ile İlişkilidir

et al. 2022

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Aim: Chronic kidney disease (CKD) is a progressive disease in which frequent cardiovascular (CV) comorbidities. High uric acid to HDL-cholesterol ratio (UHR) results were quite notable in patients receiving peritoneal dialysis. Thus, in this study, we aimed to evaluate the UHR results in dialysis patients. Materials and Methods: This retrospective, multicenter, cross-sectional study was conducted with CKD patients, and the control group consisted of hypertensive patients with a normal glomerular filtration rate (GFR). Patients' laboratory, ambulatory blood pressure monitoring, and demographic records were obtained from the follow-up cases of two university hospitals' internal medicine and nephrology departments. The patients' group then were divided into five subsets according to GFR. Results: A total of 124 CKD patients and 127 control participated in this study. All CKD patients were also identified as pre-dialysis and dialysis. The cases of UHR, non-dipper blood pressure pattern, and nocturnal heart rate (HR) were increased in CKD compared to the control group. Per disease progression, the non-dipper HR and nocturnal HR were more significant in patients receiving dialysis with high UHR than in the pre-dialysis subset. In diabetic patients with an on-targeted HbA1c, those with high UHRs still had nocturnal diastolic BP elevations. Finally, there was not an exact stagespecific result for pulse wave velocity. Conclusions: Based on our results, dialysis patients with high UHRs have higher non-dipper pulse rate, nocturnal heart rate, and nocturnal diastole blood pressure, associated with CV risk. Despite well-managed diabetes, elevated UHR in dialysis patients may be associated with non-dipper hypertension.

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Section: Discussionsupporting

confidence: 48%

“…In addition, the ratio of sUA to HDL is used as a new criterion in many cases with vascular events (15,16). In this context, the sUA / HDL ratio (UHR) was associated with CV mortality in patients undergoing peritoneal dialysis (17).…”

Section: Introductionmentioning

confidence: 99%

Hemodiyaliz Hastalarında Yüksek Serum Ürik Asit/HDL-Kolesterol Oranı Kardiyovasküler Risk ile İlişkilidir

et al. 2022

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“…As we all know, UA and high-density lipoprotein cholesterol (HDL-C) disorders are both considered as risk factors for CAD. Previous studies showed that UHR is associated with hypertension control [12], hepatic steatosis [13], thyroiditis [14], and cardiovascular mortality [15]. Some mechanistic studies reveal that high-level UA and low HDL-C may exert synergistic deleterious effects on the cardiovascular system by increasing endothelial oxidative damage and insulin resistance [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Uric Acid to High-Density Lipoprotein Cholesterol Ratio is a Novel Marker to Predict Functionally Significant Coronary Artery Stenosis

Zhao

et al. 2022

Journal of Interventional Cardiology

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Background. Intermediate coronary stenosis (ICS) is defined as a visually estimated percentage of diameter stenosis ranging between 40% and 70% by conventional coronary angiography (CAG). Whether to perform percutaneous coronary intervention (PCI) for these lesions is a challenge in clinical practice. The fractional flow reserve (FFR) can guide treatment by determining the functional significance of ICS. Studies have shown that some clinical indicators can be used to predict FFR. However, there is little research on this in the Chinese population. Methods. We retrospectively analyzed 690 patients who underwent FFR measurements to determine the functional significance of a single ICS. Patients were divided into 2 groups: FFR ≤0.8 (n = 280) and FFR >0.8 (n = 410). We compared the clinical factors between the two groups and performed multivariate logistic regression analyses to explore the risk factors. In addition, receiver-operating characteristic (ROC) curves were constructed for FFR ≤0.8 diagnoses. Results. The mean UHR (uric acid to high-density lipoprotein cholesterol ratio) level was significantly higher in the FFR ≤0.8 group ( p < 0.001 ). UHR corrects negatively with FFR (r = −0.44, p < 0.001 ). High-level UHR was an independent risk factor for the FFR ≤0.8 (OR = 7.17, 95% CI 4.17–12.34). The area under the curve (AUC) of the UHR diagnostic capacity for the FFR ≤0.8 is 0.77, with 77.3% sensitivity and 68.2% specificity. Conclusion. UHR levels were significantly increased in patients with hemodynamically significant coronary lesions. UHR is a novel predictor of functionally significant lesions in patients with a single-vessel disease of ICS.

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“…In a recent study, UHR was reported to be a predictor of metabolic syndrome in type 2 DM patients and was suggested as a marker of high sensitivity and specificity for the control of diabetes. Another study by Ruihua Liu et al showed a significant association of UHR with cardiovascular mortality in peritoneal dialysis patients with age >65 years, malnutrition, DM, and CVD history [24].…”

Section: Discussionmentioning

confidence: 96%

Is There Any Association Between Uric Acid to High-density Lipoprotein Cholesterol Ratio and Erectile Dysfunction?

Karabulut¹,

Yenice²

2021

GJU

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Objective: Elevated uric acid (UA) and low levels of high-density lipoprotein (HDL) cholesterol are associated with cardiovascular events and mortality. Erectile dysfunction (ED) has been considered an early marker of cardiovascular disease (CVD). Therefore, this study aimed to investigate the uric acid/ HDL ratio (UHR) as a nowel marker in patients with ED. Materials and Methods: The study included 147 patients with a mean age of 50 years (range 32-76 years). Retrospective analyses were performed on the patients who were admitted to urology outpatient clinics. The laboratory parameter results were retrieved from the hospital medical records, and the UHR value was calculated. Patients were categorized into three groups according to the International Index of Erectile Function (IIEF) score. UHR was compared between groups, and its predictive value was evaluated using regression analysis and ROC curve analysis. Results: Age was found to be significantly different in all three groups (Groups 1-2, p=0.001; Groups 1-3, p=0.000; Groups 2-3, p=0.001). It was observed that the degree of ED increased with age. The values of UA and HDL were similar in all groups (p>0.05). In contrast, the UHR value was statistically significantly higher 0.15 (0.083-0.288, p =0.047) in the moderate-severe ED (Group 3). ROC curve analyses revealed that UHR predicted severe ED (IIEF 5-11) with 42.9% sensitivity and 87.3% specificity (AUC:0.66, CI 95% 0.538-0.781, p=0.019). Conclusion: UHR may serve as a severe ED indicator in patients admitted to the cardiology outpatient clinic since it has a significant association with a low IIEF score.

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Uric acid to high-density lipoprotein cholesterol ratio predicts cardiovascular mortality in patients on peritoneal dialysis

Cited by 33 publications

References 40 publications

Hemodiyaliz Hastalarında Yüksek Serum Ürik Asit/HDL-Kolesterol Oranı Kardiyovasküler Risk ile İlişkilidir

Hemodiyaliz Hastalarında Yüksek Serum Ürik Asit/HDL-Kolesterol Oranı Kardiyovasküler Risk ile İlişkilidir

Uric Acid to High-Density Lipoprotein Cholesterol Ratio is a Novel Marker to Predict Functionally Significant Coronary Artery Stenosis

Is There Any Association Between Uric Acid to High-density Lipoprotein Cholesterol Ratio and Erectile Dysfunction?

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