Uric Acid Values Along with Doppler Sonography Findings as a Tool for Preeclampsia Screening

Medjedović, Edin; Suljevic, Alma; Iglica, Amer; Rama, Admir; Mahmutbegovic, Emir; Muftic, Amela; Dzihic, Ema

doi:10.5455/medarh.2019.73.408-411

Cited by 6 publications

(4 citation statements)

References 15 publications

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“…About 19% of the study participants had stillbirth deliveries which almost matched with the study ndings in China 17% by Liu D et al (19). The high proportion of stillbirth observed in this study is likely a result of preeclampsia complication like placental insu ciency (20).…”

Section: Discussionmentioning

confidence: 61%

Serum uric acid levels as a biomarker for perinatal outcomes among mothers with pre- eclampsia in Tanzania

Ulomi,

Ngarashe,

Ngarina

et al. 2023

Preprint

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Background Preeclampsia is one of the hypertensive disorders of pregnancy with significantly high morbidity and mortality to both mother and fetus. Preeclampsia is associated with high Uric acid, yet its utility in predicting the perinatal outcome is still controversial. Therefore, this study was done to determine the utility of serum uric acid levels as a biomarker for perinatal outcomes among pregnant mothers with pre-eclampsia in Tanzania.Methods A Hospital-based cross-sectional study was conducted between April and July 2020 to assess the utility of uric acid as a biomarker for perinatal outcomes in Tanzania. A total of 268 mothers were recruited consecutively soon after delivery. A checklist was used to document the mothers' and neonates' demographic and clinical characteristics, uric acid levels, and adverse neonatal birth outcomes. Analysis was done using the statistical package for social sciences (SPSS) version 23. Data were summarized using frequency and percentages for categorical variables and mean and standard deviation for continuous variables. Binary logistic regression was used to determine factors associated with poor perinatal outcomes. A P value of < 0.05 was considered statistically significant.Results Out of 268 mothers, 211 (78.7%) had raised serum uric acid, whereas an overall mean (± SD) serum uric acid level was 0.42 ± 0.09mmol/L. The magnitude of adverse perinatal outcomes was 51 (19%) stillbirth, 184(68.7%) low birth weight, 33 (12.3%) neonatal intensive care unit (NICU) admission, 72 (26.9%) low Apgar score, and 190 (70.9%) for preterm delivery. Pre-eclamptic pregnant women with serum uric acid levels < 0.35 mmol/L were more likely to have good perinatal outcomes and the difference was statistically significant, OR (0.39 (0.18–0.80) 0.011)Conclusion Serum uric acid levels can predict perinatal outcomes among pre-eclamptic pregnant women. Further study is recommended to assess the sensitivity and specificity of uric acid levels as a biomarker for perinatal outcomes.

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Section: Discussionmentioning

confidence: 61%

Serum uric acid levels as a biomarker for perinatal outcomes among mothers with pre- eclampsia in Tanzania

Ulomi,

Ngarashe,

Ngarina

et al. 2023

Preprint

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show abstract

“…Early identification of women with the risk of developing preeclampsia is a key goal of antenatal care. Biochemical tests, Doppler sonography of the uterine arteries plays a major role in predicting preeclampsia ( 3 ). Many studies have tried to link the Doppler findings of the blood flow in the uterine blood vessels with the possible early prediction and detection of preeclampsia ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

“…Many studies have tried to link the Doppler findings of the blood flow in the uterine blood vessels with the possible early prediction and detection of preeclampsia ( 4 ). During a normal pregnancy physiological changes take place to the spiral arteries with development of physiologically reduced resistance to blood flow, which is directly affecting the resistance of blood flow in the uterine arteries ( 3 ). Blood flow resistance in the uterine arteries is usually lower on the placental than on the side opposite to the placenta ( 3 , 4 ).…”

Section: Introductionmentioning

confidence: 99%

“…During a normal pregnancy physiological changes take place to the spiral arteries with development of physiologically reduced resistance to blood flow, which is directly affecting the resistance of blood flow in the uterine arteries ( 3 ). Blood flow resistance in the uterine arteries is usually lower on the placental than on the side opposite to the placenta ( 3 , 4 ). Ultrasound of the uterine arteries has become a useful method for indirect assessment of the uteroplacental circulation in early pregnancy ( 4 , 5 , 6 ).…”

Section: Introductionmentioning

confidence: 99%

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The Importance of Doppler Analysis of Uterine Circulation in Pregnancy for a Better Understanding of Preeclampsia

Medjedović¹,

Kurjak²

2021

Med Arch

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Background: The etiology of preeclampsia has still not been completely explained. Early identification of women with the risk of developing preeclampsia is a key goal of antenatal care. Objective: To investigate risk factors for preeclampsia from the history, laboratory and ultrasound findings (Doppler). Methods: Pregnant women with normal Doppler sonography in the second trimester of pregnancy were classified as a control group, while pregnant women with impaired Doppler in the second trimester were considered as the investigated group with presumably increased risk for preeclampsia. A total number of 80 patients was included in the study (40 patients in each group). Results: The difference of urea, uric acid and lactate dehydrogenase (LDH) in the serum of the control and investigated group was statistically significant, while the differences were not statistically significant for creatinine, aspartate aminotransferase (AST) and alanine aminotransferase (ALT). The presence of a notch sign during assessment of blood flow in uterine arteries in subjects in the investigated group with the diagnosis of preeclampsia had the specificity of 47.62%, and sensitivity of 88.89%. The positive predictive value of a notch sign during assessment of blood flow in uterine arteries as a marker for diagnosis of preeclampsia in the second trimester of pregnancy was 90.91%, and its negative. Systolic and diastolic blood pressure are dependent variables which are predicting preeclampsia, whilst a notch sign in uterine arteries was designated as an independent variable predicting preeclampsia. Conclusion: From the laboratory tests the following parameters were considered as the risk factors for preeclampsia: increasing levels of urea, uric acid, and LDH. Notch sign was considered to be a very strong predictor of preeclampsia, especially if present bilaterally. Doppler sonography in the second trimester of pregnancy is a good predictor for early diagnosis of preeclampsia.

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Serum uric acid levels associated with biochemical parameters linked to preeclampsia severity and to adverse perinatal outcomes

Mendonça

Silva

Mello

et al. 2022

Arch Gynecol Obstet

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Uric Acid Values Along with Doppler Sonography Findings as a Tool for Preeclampsia Screening

Cited by 6 publications

References 15 publications

Serum uric acid levels as a biomarker for perinatal outcomes among mothers with pre- eclampsia in Tanzania

Serum uric acid levels as a biomarker for perinatal outcomes among mothers with pre- eclampsia in Tanzania

The Importance of Doppler Analysis of Uterine Circulation in Pregnancy for a Better Understanding of Preeclampsia

Serum uric acid levels associated with biochemical parameters linked to preeclampsia severity and to adverse perinatal outcomes

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