“…Nettelbladt and Sandell (1963), using paper chromatography, studied the content of seventeen amino acids in the serum of patients with rheumatoid arthritis, and recorded low values for arginine, glutamine, tyrosine, and histidine, while the concentration of glutamic acid was higher in patients with rheumatoid arthritis than in healthy subjects. Kulonen and Kulonen (1960) studied the blood and urinary amino acids in rheumatoid arthritis also by paper chromatography. No difference specific to rheumatoid arthritis was observed in the blood, but the urinary elimination of glycine, glutamine, and alanine was increased, and the basic amino ANNALS OF THE RHEUMATIC DISEASES (Laine, Vainio, and Holopainen, 1954;Kalliomaki, 1954;Kalliola, Kalliomiki, and Rintala, 1957).…”