Urinary ascorbic acid and serum concentrations of circulating immune complexes and albumin in HIV infected subjects.

Onyenekwe, CC; Ezeugwunne, IP; Meludu, SC; Ilika, A; Igwegbe, AO; Ukibe, RN; Onochie, AN

doi:10.4314/jbi.v4i2.30417

Cited by 2 publications

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“…Low level of complement found in HIV infection had been attributed to complement consumption by c1q-bound immune complexes (Jarvis et al, 1993), and indeed, significant elevated levels of circulating immune complexes had been reported in HIV-infected patients in Ibadan (Onyenekwe et al, 2006).…”

Section: Discussion Immunoglobulin G M and A Levelsmentioning

confidence: 95%

Evaluation of immunoglobulin classes (IgA, IgG and IgM) levels and complement fixation activity in HIV infected subjects

Ifeanyichukwu¹,

Onyenekwe²,

Ele³

et al. 2010

International Journal of Biological and Chemical Sciences

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The study was designed to evaluate the immunoglobulin A, G and M levels and complement fixation activity in HIV infected participants, who were not administered antiretroviral therapy (ART). Eighty (80) HIV infected participants, aged between 15-55 years (38 ±10 years), were recruited for the study. Forty five (45) of the participants were classified as symptomatic HIV (stage ii), while the remaining 35 were classified as asymptomatic HIV (stage i). Similarly, 40 seronegative participants served as control. Blood samples were collected from the participants for the determination of HIV status by immunochromatography, HIV confirmation by Western blot, determination of immunoglobulin levels by immunoturbidimetry, and complement activity by complement fixation test. The IgG and IgA were significantly increased in symptomatic HIV infection compared with asymptomatic HIV infection (p<0.05). However, the value of IgM in asymptomatic and symptomatic HIV infected participants were similar (p>0.05). The complement fixation activities decreased in HIV infected patients compared with the values in HIV seronegatives. The increase in IgA concentration with HIV infected participants may suggest existence of mucosal infections, while the increase in IgG concentration in HIV infected participants may suggest evidence of increased opportunistic infection requiring IgG response. The low level of complement activity in HIV infected participants may predispose individuals with HIV infection to disease commonly controlled through immunological activity of the complement.

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Section: Discussion Immunoglobulin G M and A Levelsmentioning

confidence: 95%

Evaluation of immunoglobulin classes (IgA, IgG and IgM) levels and complement fixation activity in HIV infected subjects

Ifeanyichukwu¹,

Onyenekwe²,

Ele³

et al. 2010

International Journal of Biological and Chemical Sciences

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“…Both serum albumin concentration and CD4 + T cell count have been used to define presentation of HIV in infected individuals (Feldman et al, 2003;Olawumi and Olutunji, 2006;Onyenekwe et al, 2006). CD4+ T cell below 200 cells per mm3 has been shown to predispose to HIV/AIDS, while reduced serum albumin has also been used to define prognosis in HIV infected individuals.…”

Section: Discussionmentioning

confidence: 99%

“…Method for HIV screening and method for the detection of Plasmodium falciparum histidine rich protein-2 seroreactivity and method for determination of CD4 +T cell count by Cyflow SL Green were as previously described by Onyenekwe et al (2006). The Bromocresol Green (BCG) method was used to determine serum albumin concentration while the Haemoglobin concentration was determined by Cyanomethaemoglobin method.…”

Section: Methodsmentioning

confidence: 99%

Serum iron markers in HIV and HIV-malaria infected participants residing in malaria endemic area of South-Eastern Nigeria

Chinedum¹,

Chidiebere²,

Adamma³

et al. 2011

International Journal of Biological and Chemical Sciences

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HIV and malaria co-infections affect iron status. The present study was designed to determine the collective predictive power of some iron markers in HIV infected and malaria co-infected participants. For this study, 101 participants were randomly recruited from indivividuals requesting for HIV screening. The participants were grouped as 'asymptomatic HIV participants (n=36); asymptomatic HIV-malaria co-infected participants (n=19); symptomatic HIV participants (n=16) and HIV uninfected control participants (n=30). Blood analysis were performed for HIV infection, malaria infection, haemoglobin (g/dl), CD4 + T cell count (/mm 3 ), albumin (g/l), iron (ug/dl), UIBC (ug/dl), TIBC (ug/dl) and percent transferrin saturation (TS%). The analysis of variance (ANOVA) showed that the blood concentrations of haemoglobin (f=4.805, p<0.01), iron (f=32.368, p<0.01), TIBC (f= 20.467, p<0.01), TS% (f=7.616, p<0.01) and albumin (f=16.150, p<0.01), were significantly different amongst the groups. The serum albumin, iron, TIBC and TS% were significantly lowered in asymptomatic HIV, asymptomatic HIV-malaria co-infected and symptomatic HIV participants compared respectively with corresponding parameter in the control participants (p<0.01). The CD4 + T cell count was significantly lowered in symptomatic HIV participants compared with asymptomatic HIV participants with or without malaria co-infection (p<0.01). The study suggests that iron status may be affected in HIV infected individuals. The implications of the result are discussed.

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Urinary ascorbic acid and serum concentrations of circulating immune complexes and albumin in HIV infected subjects.

Cited by 2 publications

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Evaluation of immunoglobulin classes (IgA, IgG and IgM) levels and complement fixation activity in HIV infected subjects

Evaluation of immunoglobulin classes (IgA, IgG and IgM) levels and complement fixation activity in HIV infected subjects

Serum iron markers in HIV and HIV-malaria infected participants residing in malaria endemic area of South-Eastern Nigeria

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