2016
DOI: 10.1016/j.envres.2016.02.006
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Urinary bisphenol A concentrations positively associated with glycated hemoglobin and other indicators of diabetes in Canadian men

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Cited by 34 publications
(19 citation statements)
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“…In adults, the relationship between BPA and glucose homeostasis has been relatively well-studied. In general, BPA has been associated with increased glycated hemoglobin (HbA1c) levels in adults [ 49 , 50 ], greater serum insulin levels and insulin resistance [ 51 ], and higher risk of prediabetes [ 52 ] and type 2 diabetes [ 53 ]. Moreover, a prospective study identified a susceptible group of adults for BPA effects on glucose homeostasis based on a genetic risk score [ 54 ].…”
Section: Resultsmentioning
confidence: 99%
“…In adults, the relationship between BPA and glucose homeostasis has been relatively well-studied. In general, BPA has been associated with increased glycated hemoglobin (HbA1c) levels in adults [ 49 , 50 ], greater serum insulin levels and insulin resistance [ 51 ], and higher risk of prediabetes [ 52 ] and type 2 diabetes [ 53 ]. Moreover, a prospective study identified a susceptible group of adults for BPA effects on glucose homeostasis based on a genetic risk score [ 54 ].…”
Section: Resultsmentioning
confidence: 99%
“…Previous observational studies have shown positive associations between BPA and indices of glucose metabolism and type 2 diabetes incidence [23, 51, 52]. For example, Tai and Chen [52] found that urinary BPA levels in the third and fourth quartiles, compared with the reference quartile, were significantly associated with increased HbA 1c (0.46% and 0.44% increase, respectively), fasting glucose levels (0.092 mmol/L and 0.075 mmol/L increase, respectively), and doctor-diagnosed type 2 diabetes in men. However, these studies were strictly associative in nature, and well-controlled experimental studies are needed to determine the direct effect of orally administered BPA on indices of glucose metabolism and insulin resistance.…”
Section: Discussionmentioning
confidence: 99%
“…Studies based on NHANES 2003-2008 reported a connection between BPA levels and the incidence of diabetes (Shankar & Teppala 2011) and prediabetes (Sabanayagam et al 2013) independently of traditional diabetes risk factors. BPA has also been linked to the prevalence of IR, hyperinsulinemia and adverse glucose homeostasis (Wang et al 2012, Beydoun et al 2014, Tai & Chen 2016. In children, BPA has been associated to the presence of IR regardless of BMI (Menale et al 2017).…”
Section: Edcs and T2dmentioning
confidence: 99%