Urinary Dipyrrylmethenes in Patients with Porphyria

Sears, William; Eales, L

doi:10.1159/000459301

Cited by 5 publications

(1 citation statement)

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“…Dipyrrylmethenes (absorption maximum 483 nm) and urobilinoids (495 nm, fig. 3) absorb close to one another in thisarea (19). occurred in the organism before the excretion of urine from the bladder.…”

Section: Resultsmentioning

confidence: 76%

Porphyrinogens in Urine in Various Types of Porphyrias

Martásek¹,

Jirsa²,

Kordač³

1982

CCLM

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Porphyrinogens were determined in very fresh, diluted morning urine in two types of hepatic porphyria, using a simple and very quick spectrophotometric method. It was shown that acidification by itself is insufficient for the complete conversion of colourless porphyrinogens into porphyrins in photometric determination of porphyrins in diluted urine. A correlation was shown between percentual content of porphyrinogens and the sum of pentacarboxyporphyrin and coproporphyrin. A difference was found between the excretion of porphyrinogens in morning fresh urine in porphyria cutanea tarda (average porphyrinogen fraction 22.5%, SD 10.3% of total porphyrins) and in acute intermittent porphyria (average porphyrinogen fraction 77.1 %, SD 9.3% of total porphyrins). The method is at the same time suitable for the detection of urobilinoids in urine. Oxidation of the urine in acute intermittent porphyria is recommended before adsorption on talc and subsequent thin j layer chromatography, because porphyrinogens are not adsorbed on talc.

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Section: Resultsmentioning

confidence: 76%