Urinary excretion of 1-methylhistidine: A qualitative indicator of exogenous 3-methylhistidine and intake of meats from various sources

Sjölin, Jan; Hjort, G. H.; Friman, Göran; Hambræus, Leif

doi:10.1016/0026-0495(87)90245-9

Cited by 67 publications

(63 citation statements)

References 42 publications

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“…Indeed, proteolysis is not the only source of 3MH because significant amounts of 3MH can be taken up with the food. Endogenous 3MH can be distinguished from the exogenous 3MH by screening for 1MH, a methylated derivative of histidine that is not formed in humans, although common in other animals (34). Because meat was replaced by a mixture of amino acids, the urinary 1MH:creatinine ratio decreased from the 1st day of MET-free diet, and this decrease was correlated with urinary 3MH:creatinine ratio.…”

Section: Discussionmentioning

confidence: 97%

Optimal Methionine-Free Diet Duration for Nitrourea Treatment: A Phase I Clinical Trial

Durando

Thivat

Farges

et al. 2007

Nutrition and Cancer

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In animal models, methionine (MET) restriction in association with chloroethylnitrosoureas led to a substantial improvement. On this basis, we initiated a Phase I clinical trial of dietary MET restriction in association with chloroethylnitrosourea (cystemustine) treatment for patients with recurrent glioma or metastatic melanoma. Our purpose was 1) to determine the optimal MET-free diet duration for a maximum depletion of plasma MET and 2) to evaluate the feasibility of this association. A total of 10 patients received 4 cycles of 2 wk of an association of a MET-free diet of 1, 2, 3, or 4 consecutive days and cystemustine (60 mg/m(2)). For each cycle, plasma MET concentrations, nutritional status (weight, albumin, prealbumin) and toxicity were measured. Conversely, fed-state concentrations of plasma MET (12 AM) were reduced by dietary MET restriction, with an optimal depletion of 41% at the 1st day of MET-free diet without effect of the extending MET-free diet period. Indeed, we demonstrated the feasibility, that is, good diet acceptability and good tolerance (nutritional status and toxicity), of the association of a MET-free diet and cystemustine treatment. Based on these results, a Phase II clinical trial has been initiated to test the activity of the association of a 1-day MET-free diet with cystemustine treatment.

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Section: Discussionmentioning

confidence: 97%

Optimal Methionine-Free Diet Duration for Nitrourea Treatment: A Phase I Clinical Trial

Durando

Thivat

Farges

et al. 2007

Nutrition and Cancer

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“…It is known that the majority of urinary 1-methylhistidine is from dietary sources, particularly from meat (Sjolin et al , 1987), whereas 3-methylhistidine is found in the diet and also occurs as a result of muscle catabolism (Lukaski and Mendez, 1980). A controlled feeding study investigated 1-methylhistdine and 3-methylhistidine as potential biomarkers of meat intake and found a dose-dependent associated between meat intake and urinary excretion of 1- and 3-methylhistdine (Cross et al , 2011).…”

Section: Introductionmentioning

confidence: 99%

Urinary 1-methylhistidine and 3-methylhistidine, meat intake, and colorectal adenoma risk

Cross

Major

Rothman

et al. 2014

European Journal of Cancer Prevention

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Background Self-reported red and processed meat intake has been positively associated with colorectal adenoma and cancer; however, measurement error in self-reported data can attenuate risk estimates, increasing the need for improved exposure assessment methods to better understand this association. A controlled feeding study revealed that urinary 1- and 3-methylhistidine were dose-dependently associated with meat intake; our aim was to examine these analytes in relation to colorectal adenoma. Methods Individuals undergoing routine cancer screening by sigmoidoscopy or colonoscopy were recruited for a colorectal adenoma case-control study; participants completed a food frequency questionnaire, meat questionnaire, and donated urine. Urinary 1- and 3-methylhistidine were measured in 131 case-control pairs (age, sex, and smoking matched); odds ratios (ORs) and 95% confidence intervals (CI) were calculated by logistic regression. Results Although the mean self-reported red meat intake was higher in cases (59g/day) than controls (48g/day), mean urinary 1- and 3-methylhistdine did not differ by case status (P values=0.72). Neither urinary 1-methylhistdine nor 3-methylhisdidine were associated with colorectal adenoma (ORcontinuous=0.90, 95% CI:0.53–1.54; ORcontinuous=0.90, 95% CI:0.69–1.17, respectively). A variable combining self-reported red meat intake with urinary 1- and 3-methylhistidine levels was not associated with colorectal adenoma. Analyzing urine samples from multiple days from 17 individuals revealed intraclass correlations of 0.52 and 0.49 for 1- and 3-methylhistidine, respectively; this variability could result in attenuated risks. Conclusion Urinary 1- and 3-methylhistidine, measured in one sample, were not associated with colorectal adenoma.

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“…1, which is not formed in humans, but it is common in other animals. The urinary level of 1MH correlates well with that of 3MH from the diet, so that their simultaneous determination can be used to follow the proteolysis of the skeletal muscle proteins [4].…”

Section: Introductionmentioning

confidence: 99%

“…1, which is a product of methylation on the imidazole moiety of histidine molecule occurring in the course of post-translation modifications of actin and myosin after their biosynthesis. Owing to absence of its genetic code, 3MH is not utilized in proteosynthesis, and because it is not metabolized further, it is excreted as such in the urine [3,4].…”

Section: Introductionmentioning

confidence: 99%

Determination of 3-methylhistidine and 1-methylhistidine in untreated urine samples by capillary electrophoresis

Tůma

Samcová

Balínová

2005

Journal of Chromatography B

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Urinary excretion of 1-methylhistidine: A qualitative indicator of exogenous 3-methylhistidine and intake of meats from various sources

Cited by 67 publications

References 42 publications

Optimal Methionine-Free Diet Duration for Nitrourea Treatment: A Phase I Clinical Trial

Optimal Methionine-Free Diet Duration for Nitrourea Treatment: A Phase I Clinical Trial

Urinary 1-methylhistidine and 3-methylhistidine, meat intake, and colorectal adenoma risk

Determination of 3-methylhistidine and 1-methylhistidine in untreated urine samples by capillary electrophoresis

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