Urinary Excretion of 17-Ketosteroids in South Indian Populations

Henrotte, J. G.; Subrahmanyam, Sarada; Ramanathan, Anand; Satyanarayanan, M.P.

doi:10.1016/s0140-6736(65)91661-2

Cited by 3 publications

(1 citation statement)

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“…Thyssen et a/. (1967) showed that differences in cortisol production rates between Europeans, Bantu and Masai living in Kenya could be explained on the basis of body weight (or body surface), Similar con-clusions were reached as regards 17-ketosteroid excretion levels in Indians and Europeans in India (Henrotte et a/., 1965). It was found in South Africa that when the Bantu change their rural life for an urban one, they experience a marked increase in body weight which in turn leads to an increase in the frequency of oestrogenic smears in postmenopausal women (de Waard and Oettle, 1965).…”

Section: Differences In Adrenocortical Function Have Been Reported Bementioning

confidence: 86%

The epidemiology of breast cancer; Review and prospects

Waard

1969

Intl Journal of Cancer

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In the epidemiology of a disease, which is multifactorial lo such an extent as we believe breast cancer to be, attention should be paid even to " In his review on the epidemiology of breast cancer, Lilienfeld (1963) made a plea for integrating laboratory investigations with epidemiological field studies. Six years later we are beginning to reach an era in which the epidemiologist turns to his friends in biochemistry (or they turn to him) in order to tackle this vast problem together. The task is vast indeed but not insoluble since we now have sufficient data on possible risk factors to undertake a number of prospective studies which will give us by, say, 1980, an insight into its aetiology, comparable to the knowledge which we have obtained over the past 20 years in coronary heart disease.The comparison with coronary heart disease is relevant in that laboratory studies in lipid metabolism have greatly helped us in understanding the interactions between environmental and " endogenous " factors, e.g. the effect of nutrition and exercise on blood cholesterol levels. In a similar way epidemiologists will have to venture into the field of endocrinology to advance their understanding of breast cancer. It will not be enough if they simply hand over a number of bottles of urine or some tubes with frozen plasma from cancer patients and controls to their biochemical colleagues. We shall have to learn more about the factors which might influence hormone patterns in normal women. Part of this knowledge has already been obtained by clinical endocrinologists, e.g. the effects of over-eating and starvation on adrenocortical hormone production and excretion; other aspects will arise through questions by epidemiologists.In the meantime, biochemists are introducing methods for the measurement of pituitary hormones in human body fluids. It will be of particular importance to develop a method for the estimation of human prolactin.What do we know? In human beings, as well as in other vertebrate species, possible aetiological factors in breast cancer development can be divided into four categories: 1) Hormonal factors; 2) Genetic factors; 3) Environmental factors;

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Section: Differences In Adrenocortical Function Have Been Reported Bementioning

confidence: 86%