Urinary Excretion of Androgenic Substances After Intramuscular and Oral Administration of Testosterone Propionate to Humans 1

Dorfman, Ralph I.; Hamilton, James B.

doi:10.1172/jci101027

Cited by 21 publications

(3 citation statements)

References 12 publications

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“…No attempt was made to estimate the percentage of recovery in the urine after testO' sterone injections. In general, however, the rise in excretion checked fairly well with the findings of others (8,9) and corresponded to the size of the dose.…”

supporting

confidence: 84%

The Urinary Excretion of Estrogens, Androgens and FSH Following the Administration of Testosterone to Human Female Castrates

1939

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supporting

confidence: 84%

The Urinary Excretion of Estrogens, Androgens and FSH Following the Administration of Testosterone to Human Female Castrates

1939

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“…The excretion rates were very irregular and frequently higher after hysterectomy and oophorectomy than before the operation (158). Injection of testosterone propionate in some of the women patients was followed by a distinct increase in androgen excretion (158) .. All investigators on hypogonadal men and castrates agree that the low rate of excretion of androgens is increased by testosterone propionate therapy (159,160,161,162,163). An increased renal excretion of androgens following testosterone propionate injections has also been observed in the immature monkey (164), in the dog (165), and in the rabbit (166).…”

Section: Separation Of Androgens and Related Compounds From Urinementioning

confidence: 99%

Hormones

Koch¹

1940

Annu. Rev. Biochem.

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Because the more definitely biochemical advances in the field of hormones are very nearly limited to those of the steroid type together with the limited space available for reviewing a very extensive litera ture, I have taken advantage of the editors' liberal policy and have limited this review to the biochemistry of the steroid hormones. ESTROGENSDistribution and forms of estrogens.-Although all of the estro gen activity in cow and hog ovaries is considered to be in the free form, only 50 to 75 per cent is free in the horse ovary or its follicular fluid (1). During pregnancy 50 to 75 per cent of the blood estrogens in women are in the free form (2). The best method of hydrolysis of the conjugated forms of estrogens in pregnancy urine is still a prob lem. One g.roup recommends boiling the pregnancy urine for ten minutes with 15 per cent concentrated hydrochloric added. Longer heating results in serious loss of estrogens (3). Others recommend that the urine from pregnant mares be allowed to stand at pH 0.4 to 0.6 at room temperature for at least four weeks (4). The writer, in studies on urine from normal men and nonpregnant women, has obtained the highest yield of estrogens by boiling the urine previously acidified to pH 1 to 1.2 with hydrochloric acid for fifteen minutes.Longer boiling at this pH also causes destruction of estrogens. The gradual increase in the urinary excretion of estrogens in women to a peak of 80,000 rat units near the termination has been confirmed, but in one case of toxemia of pregnancy, the excretion was subnormal.

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“…(1) Three different methods of hydrating rats were explored and the diuresis produced was measured in 4 separate ways. (1) Three different methods of hydrating rats were explored and the diuresis produced was measured in 4 separate ways.…”

mentioning

confidence: 99%

Reproducible Diuresis and Chloruresis for Bioassay of Antidiuretic Activity

Ham

1943

Experimental Biology and Medicine

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Urinary Excretion of Androgenic Substances After Intramuscular and Oral Administration of Testosterone Propionate to Humans 1

Cited by 21 publications

References 12 publications

The Urinary Excretion of Estrogens, Androgens and FSH Following the Administration of Testosterone to Human Female Castrates

The Urinary Excretion of Estrogens, Androgens and FSH Following the Administration of Testosterone to Human Female Castrates

Hormones

Reproducible Diuresis and Chloruresis for Bioassay of Antidiuretic Activity

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