Urinary Excretion of Free Histamine in the Newborn Infant

Cooper, L. V.; Davis, JohnA.

doi:10.1016/s0140-6736(68)90423-6

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…Similarly, the eosinophil count had a logarithmically Table; they have a significantly higher count than normal babies (p = 0 001). Discussion Free histamine has been shown to be present in increased amounts in the urine of babies severely asphyxiated at birth (Cooper and Davis, 1968). As every birth involves a short period of asphyxia (James, 1960), one might have expected, if urinary free histamine is derived from the plasma, that the plasma levels of histamine might be higher on the first day of life.…”

Section: Resultsmentioning

confidence: 97%

“…Babies asphyxiated at birth and premature babies who develop the idiopathic respiratory distress syndrome of the newborn excrete larger than normal quantities of histamine in the urine during the first 24 hours of life (Cooper and Davis, 1968). Since histamine could play a part in the genesis of the respiratory distress syndrome it seemed important to establish normal plasma levels for the newborn.…”

mentioning

confidence: 99%

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Plasma histamine levels during the first week of life.

Cooper¹,

Harvey²,

Davis³

1969

Archives of Disease in Childhood

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Section: Resultsmentioning

confidence: 97%

mentioning

confidence: 99%

Plasma histamine levels during the first week of life.

Cooper¹,

Harvey²,

Davis³

1969

Archives of Disease in Childhood

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“…Yet, low albumin levels were found in infants who developed necrotizing enterocolitis, but not in a control group matched for mode of delivery, gestational age, birth weight, sex, race and type of feed [1]. Infants with respiratory distress have high histamine concentrations which aect capillary permeability [7] and thus might be predicted``pathologically'' to have low albumin levels due to loss from the circulation into, for example, the lungs [17].…”

Section: Hypoalbuminaemiamentioning

confidence: 99%

Use and misuse of albumin infusions in neonatal care

Greenough¹

1998

Eur J Pediatr

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Immediate effects of albumin infusion in ill premature neonates.

Greenough

Greenall

Gamsu

1988

Archives of Disease in Childhood

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SUMMARY Ten normotensive premature infants with idiopathic respiratory distress syndrome, and albumin concentrations of less than 30 g/l were given 5 ml/kg of 20% salt poor albumin by infusion. Concentrations measured six hours after infusion had increased significantly and these were associated with significant reduction in weight and improvement in urine output.Sick premature infants are often oedematous in spite of being hypovolaemic. ' The present study was designed to find out whether infusions of albumin were effective in treating hypoalbuminaemia in normotensive sick infants. Patients and methodsInfants less than 2 weeks of age, except those receiving peritoneal dialysis and those with chest drains in situ (both of which interfere with weighing) were eligible for the study. Babies given albumin infusions for the emergency treatment of hypotension were also excluded.Ten infants entered the study. Their mean birth weight was 1390 g (range 560-3315 g) and mean gestational age 29 weeks (range 24-36). The postnatal age at the time of infusion ranged from 24 hours to 5 days, mean age 1*7 days. All had a clinical diagnosis of respiratory distress syndrome and were receiving artificial ventilation by a Sechrist ventilator. They were ventilated at peak inspiratory pressures ranging from 14-32 cm H20. Five of the infants were paralysed before and during the study. All 10 infants had albumin concentrations of <30 g/l, with peripheral oedema. The content of fluid to be given to each baby was decided daily. On the first day 40 ml/kg were given and this amount was not increased if the infant gained weight during the first three days.Urea, electrolytes, and albumin concentrations were measured daily in all babies, and infants who were hypoalbuminaemic (<30 g/l) were entered into the study. A solution of 5 ml/kg/20% salt poor albumin was then infused, and the volume subtracted from the total daily fluid requirement. Before the transfusion and at the end of the six hours after it the infant was weighed, and urea, electrolytes, and albumin concentrations measured again. For six hours before and after the infusion urine output was measured. Manual expression was not used and urine was collected that had been voided spontaneously in the two six hour periods.' During a similar period blood pressure was recorded hourly as the mean of the systolic and diastolic pressures using an intra-arterial transducer, and reported as the average for each six hour period.During the 12 hours of the study period no other alteration was made in the infant's fluid input, nor was there any change made in the type of incubator or the use of overhead heaters. Twelve hours was chosen as the study period as it was the longest over which the fluid intake of sick infants on ventilators could be guaranteed to be constant. Treatment with phototherapy was recorded.To assess any effects of the albumin infusion, albumin and electrolyte concentrations, blood pressure, weight, and urine output were compared before and after the infusion.Ethical permission ...

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Urinary Excretion of Free Histamine in the Newborn Infant

Cited by 3 publications

References 15 publications

Plasma histamine levels during the first week of life.

Plasma histamine levels during the first week of life.

Use and misuse of albumin infusions in neonatal care

Immediate effects of albumin infusion in ill premature neonates.

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