URINARY EXCRETION OF PREGNANDIOL COMPLEX BY MALES III. FOLLOWING INTRAMUSCULAR ADMINISTRATION OF DESOXYCORTICOSTERONE ACETATE<sup>1</sup>

Cuyler, W. Kenneth; Ashley, Catherine; Hamblen, E. C.

doi:10.1210/endo-27-2-177

Cited by 50 publications

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“…Although urinary pregnanediol is not the only metabolite of progesterone (de Watteville, 195 1) and may indeed be the metabolite of other substances, for example, desoxycorticosterone (Cuyler, Ashley and Hamblen, 1940), yet the broad generalization that urinary pregnanediol is mainly derived from progesterone may still be considered sound.…”

Section: Third Investigationmentioning

confidence: 99%

Ovarian Activity Following Hysterectomy

Whttelaw¹

1958

BJOG

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Section: Third Investigationmentioning

confidence: 99%

Ovarian Activity Following Hysterectomy

Whttelaw¹

1958

BJOG

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“…The exact nature of the theca cell hormone still requires investigation and an attempt in this direction is being made in this University. However, on the basis of the present study it would appear to be an androgen incapable, as a rule, of breaking down into a 17-ketosteroid, and with a chemical structure probably closely related to desoxycorticosterone (Cuyler, Ashley and Hamblen, 1940), and more closely to progesterone than is testosterone, in view of the large quantities of pregnanediol (Leventhal and Cohen, 1951) often excreted in the urine of patients with this syndrome.…”

mentioning

confidence: 56%

THE OVARIAN THECA CELL Part IV–The Hyperthecosis Syndrome

Shippel

1955

BJOG

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“…Many workers have found an increased pregnanediol output in patients suffering from adrenal disorders. This has frequently been noted in cases of adrenal hyperplasia [Talbot, Butler & Berman, 1942;Finkler, 1941;Malley & Bradshaw, 1941], High levels of urinary pregnanediol are encountered less often in cases with adrenal tumours, but have been described [Diczfalusy & Luft, 1952;Lloyd, Lobotsky, Jones, Fredericks & Watt, 1951]. These investigations did not include evidence of identification of the substance measured.…”

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confidence: 99%

The Excretion of Pregnanediol and Adrenocortical Activity

Klopper¹,

Strong²,

Cook³

1957

Journal of Endocrinology

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A new method of assay was applied to the determination of pregnanediol in urines from patients in whom the presence of a placenta or a corpus luteum could be excluded. The normal variation of pregnanediol content in such urines was examined. It was shown that operative stress or the intravenous administration of corticotrophin caused an increased output of pregnanediol. Quantitatively significant amounts of urinary pregnanediol could not be detected after adrenalectomy nor did adrenalectomized patients respond to corticotrophin by an increased pregnanediol output. It is considered that the adrenal contributes to the pregnanediol found in urine and that the determination of urinary pregnanediol may be of value in the study of adrenal function.Pregnane-3a:20a-diol is a neutral steroid occurring in urine as a conjugate of glucuronic acid. It is a metabolite of progesterone. When progesterone is administered to human subjects, some 10-20% of the hormone can be recovered as urinary preg¬ nanediol. It is generally supposed that the excretion of urinary pregnanediol can be used as a measure of the progesterone produced by the corpus luteum and the placenta. Pregnanediol was first isolated from pregnancy urine by Marrian [1929]. Since then many methods have been proposed for its quantitative deter¬ mination in urine. As these methods have become more reliable, the changes in excretion during the menstrual cycle and pregnancy have been more clearly under¬ stood. It has also become evident that not all the pregnanediol in urine can be accounted for by the activity of either the corpus luteum or the placenta. The work of Engel, Thorn & Lewis [1941] showed that small amounts of authentic 5/?-pregnane3a:20a-diol could be isolated from a large volume of pooled normal male urine. These findings were supported by the work of Heard & Hoffman [1941] and of Westphal [ 1944]. The latter estimated that male urine contained 0-7 mg pregnanediol/1.Although a third source of urinary pregnanediol is now established, its origin has not been conclusively demonstrated. Some of the urinary pregnanediol is thought to originate from the adrenal. Many workers have found an increased pregnanediol output in patients suffering from adrenal disorders.

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URINARY EXCRETION OF PREGNANDIOL COMPLEX BY MALES III. FOLLOWING INTRAMUSCULAR ADMINISTRATION OF DESOXYCORTICOSTERONE ACETATE¹

Cited by 50 publications

References 0 publications

Ovarian Activity Following Hysterectomy

Ovarian Activity Following Hysterectomy

THE OVARIAN THECA CELL Part IV–The Hyperthecosis Syndrome

The Excretion of Pregnanediol and Adrenocortical Activity

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URINARY EXCRETION OF PREGNANDIOL COMPLEX BY MALES III. FOLLOWING INTRAMUSCULAR ADMINISTRATION OF DESOXYCORTICOSTERONE ACETATE1

Cited by 50 publications

References 0 publications

Ovarian Activity Following Hysterectomy

Ovarian Activity Following Hysterectomy

THE OVARIAN THECA CELL Part IV–The Hyperthecosis Syndrome

The Excretion of Pregnanediol and Adrenocortical Activity

Contact Info

Product

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URINARY EXCRETION OF PREGNANDIOL COMPLEX BY MALES III. FOLLOWING INTRAMUSCULAR ADMINISTRATION OF DESOXYCORTICOSTERONE ACETATE¹