Urinary levels of pyrethroid pesticides and determinants in pregnant French women from the Elfe cohort

Dereumeaux, Clémentine; Saoudi, Abdesattar; Goria, Sarah; Wagner, Vérène; Crouy-Chanel, Perrine de; Pêcheux, Marie-Germaine; Berat, Bénédicte; Zaros, Cécile; Guldner, Laurence

doi:10.1016/j.envint.2018.04.042

Cited by 68 publications

(35 citation statements)

References 42 publications

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“…Urinary pesticide levels were comparable to those of previous studies performed on European populations in other countries. Median pyrethroid exposures based on the metabolite 3-PBA have been found to range from 0.018 to 0.43 µg/L in France (Dereumeaux et al 2018;Viel et al 2015), Germany (Schulz et al 2009), Poland (Wielgomas and Piskunowicz 2013), Denmark (Dalsager et al 2018), and are thus comparable to concentrations from our study (0.12 µg/L). For organophosphates, the median of the molar sum of organophosphates metabolites in our study (34.7 nM, Table S3) was comparable to values reported in Denmark (56.5 nM, n = 564; (Dalsager et al 2018) and France (38.8 nM, n = 254;(Debost-Legrand et al 2016).…”

Section: Discussionsupporting

confidence: 86%

Impacts of dietary exposure to pesticides on faecal microbiome metabolism in adult twins

Mesnage

Rce

et al. 2021

Preprint

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Concerns have been raised as to whether the consumption of foodstuffs contaminated with pesticides can contribute to the development of chronic human diseases by affecting microbial community function in the gut. We provide the first associations between urinary pesticide excretion and the composition and function of the faecal microbiome in 65 twin pairs in the UK. Biomonitoring of exposure to 186 common insecticide, herbicide, or fungicide residues showed the presence of pyrethroid and/or organophosphorus insecticide residues in all urine samples, while the herbicide glyphosate was found in 45% of individuals. Other pesticides such as DEET, imidacloprid or dithiocarbamate fungicides were less frequently detected. While the geographic location or the rural/urban environment had no influence on pesticide urinary excretion, food frequency questionnaires showed that DMTP levels, a metabolite of organophosphates, was higher with increased consumption of fruit and vegetables. Multivariable association between urinary pesticide excretion and faecal microbial composition and function were determined with shotgun metagenomics and metabolomics. A total of 34 associations between pesticide residues concentrations and faecal metabolite concentrations were detected. Glyphosate excretion was positively associated to an increased bacterial species richness, as well as to fatty acid metabolites and phosphate levels. The insecticide metabolite Br2CA, reflecting deltamethrin exposure, was positively associated with the mammalian phytoestrogens enterodiol and enterolactone, and negatively associated with some N-methyl amino acids. Urine metabolomics performed on a subset of samples did not reveal associations with the excretion of pesticide residues. Our results highlight the need for future interventional studies to understand effects of pesticide exposure on the gut microbiome and possible health consequences.

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Section: Discussionsupporting

confidence: 86%

Impacts of dietary exposure to pesticides on faecal microbiome metabolism in adult twins

Mesnage

Rce

et al. 2021

Preprint

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“…Pyrethroid residues have been reported in dust, cloth, union suit samples, diaper, military uniform, and urine samples (Bradman et al, 2007; Proctor et al, 2019). Pyrethroid residues in the urine samples of pregnant women have been reported from Jiangsu China and France (Qi et al, 2012; Dereumeaux et al, 2018; Kamai et al, 2019). Children in United States are more exposed to pyrethroids as compared to organic food taking children of other areas.…”

Section: Hazardous Effects Of Pyrethroidsmentioning

confidence: 99%

Insight Into Microbial Applications for the Biodegradation of Pyrethroid Insecticides

et al. 2019

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Pyrethroids are broad-spectrum insecticides and presence of chiral carbon differentiates among various forms of pyrethroids. Microbial approaches have emerged as a popular solution to counter pyrethroid toxicity to marine life and mammals. Bacterial and fungal strains can effectively degrade pyrethroids into non-toxic compounds. Different strains of bacteria and fungi such as Bacillus spp., Raoultella ornithinolytica, Psudomonas flourescens , Brevibacterium sp., Acinetobactor sp., Aspergillus sp., Candida sp., Trichoderma sp., and Candia spp., are used for the biodegradation of pyrethroids. Hydrolysis of ester bond by enzyme esterase/carboxyl esterase is the initial step in pyrethroid biodegradation. Esterase is found in bacteria, fungi, insect and mammalian liver microsome cells that indicates its hydrolysis ability in living cells. Biodegradation pattern and detected metabolites reveal microbial consumption of pyrethroids as carbon and nitrogen source. In this review, we aim to explore pyrethroid degrading strains, enzymes and metabolites produced by microbial strains. This review paper covers in-depth knowledge of pyrethroids and recommends possible solutions to minimize their environmental toxicity.

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“…2013) and child care facilities (Morgan et al. 2007), as well as urinary samples collected from mothers (Dereumeaux et al. 2018; Qi et al.…”

Section: Introductionmentioning

confidence: 99%

Influence of Nanomolar Deltamethrin on the Hallmarks of Primary Cultured Cortical Neuronal Network and the Role of Ryanodine Receptors

Zheng

Feng

et al. 2019

Environ Health Perspect

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Background:The pyrethroid deltamethrin (DM) is broadly used for insect control. Although DM hyperexcites neuronal networks by delaying inactivation of axonal voltage-dependent Na+ channels, this mechanism is unlikely to mediate neurotoxicity at lower exposure levels during critical perinatal periods in mammals.Objectives:We aimed to identify mechanisms by which acute and subchronic DM altered axonal and dendritic growth, patterns of synchronous Ca2+ oscillations (SCOs), and electrical spike activity (ESA) functions critical to neuronal network formation.Methods:Measurements of SCOs using Ca2+ imaging, ESA using microelectrode array (MEA) technology, and dendritic complexity using Sholl analysis were performed in primary murine cortical neurons from wild-type (WT) and/or ryanodine receptor 1 (RyR1T4826I/T4826I) mice between 5 and 14 d in vitro (DIV). [H3]ryanodine binding analysis and a single-channel voltage clamp were utilized to measure engagement of RyRs as a direct target of DM.Results:Neuronal networks responded to DM (30–70 nM) as early as 5 DIV, reducing SCO amplitude and depressing ESA and burst frequencies by 60–70%. DM (10–300 nM) enhanced axonal growth in a nonmonotonic manner. DM≥100 nM enhanced dendritic complexity. DM stabilized channel open states of RyR1, RyR2, and cortical preparations expressing all three isoforms. DM (30 nM) altered gating kinetics of RyR1 channels, increasing mean open time, decreasing mean closed time, and thereby enhancing overall open probability. SCO patterns from cortical networks expressing RyR1T4826I/T4826I were more responsive to DM than WT. RyR1T4826I/T4826I neurons showed inherently longer axonal lengths than WT neurons and maintained less length-promoting responses to nanomolar DM.Conclusions:Our findings suggested that RyRs were sensitive molecular targets of DM with functional consequences likely relevant for mediating abnormal neuronal network connectivity in vitro. https://doi.org/10.1289/EHP4583

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Urinary levels of pyrethroid pesticides and determinants in pregnant French women from the Elfe cohort

Cited by 68 publications

References 42 publications

Impacts of dietary exposure to pesticides on faecal microbiome metabolism in adult twins

Impacts of dietary exposure to pesticides on faecal microbiome metabolism in adult twins

Insight Into Microbial Applications for the Biodegradation of Pyrethroid Insecticides

Influence of Nanomolar Deltamethrin on the Hallmarks of Primary Cultured Cortical Neuronal Network and the Role of Ryanodine Receptors

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