Urinary liver-type fatty acid binding protein as a useful biomarker in chronic kidney disease

Kamijo, Aki; Sugaya, Takeshi; Hikawa, Akihisa; Yamanouchi, Masaya; Hirata, Yasunobu; Ishimitsu, Toshihiko; Numabe, Atsushi; Takagi, Masao; Hayakawa, Hiroshi; Tabei, Fumiko; Sugimoto, Tsuneaki; Mise, Naofumi; Omata, Masao; Kimura, Kenjiro

doi:10.1007/s11010-005-9047-9

Cited by 154 publications

(115 citation statements)

References 7 publications

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“…Kamijo et al demonstrated that in patients with mild nondiabetic CKD, significantly higher L-FABP levels were associated with a more rapid rate of CKD progression. Notably, neither serum creatinine nor urine protein differed between patients who did versus those who did not experience rapid CKD progression (26), similar to our study findings. The elevated urinary IL-18 and L-FABP levels in the AKI-positive patients in our cohort could support ongoing inflammation as a source of kidney injury.…”

Section: Discussionsupporting

confidence: 91%

Follow-Up Renal Assessment of Injury Long-Term After Acute Kidney Injury (FRAIL-AKI)

Cooper

Claes

Goldstein

et al. 2016

Clinical Journal of the American Society of Nephrology

116

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Background and objectives Novel urinary kidney damage biomarkers detect AKI after cardiac surgery using cardiopulmonary bypass (CPB-AKI). Although there is growing focus on whether AKI leads to CKD, no studies have assessed whether novel urinary biomarkers remain elevated long term after CPB-AKI. We assessed whether there was clinical or biomarker evidence of long-term kidney injury in patients with CPB-AKI.Design, setting, participants, & measurements We performed a cross-sectional evaluation for signs of chronic kidney injury using both traditional measures and novel urinary biomarkers in a population of 372 potentially eligible children (119 AKI positive and 253 AKI negative) who underwent surgery using cardiopulmonary bypass for congenital heart disease at Cincinnati Children's Hospital Medical Center between 2004 and 2007. A total of 51 patients (33 AKI positive and 18 AKI negative) agreed to long-term assessment. We also compared the urinary biomarker levels in these 51 patients with those in healthy controls of similar age.Results At long-term follow-up (mean duration6SD, 760.98 years), AKI-positive and AKI-negative patients had similarly normal assessments of kidney function by eGFR, proteinuria, and BP measurement. However, AKI-positive patients had higher urine concentrations of IL-18 (48.5 pg/ml versus 20.3 pg/ml [P=0.01] and 20.5 pg/ml [P,0.001]) and liver-type fatty acid-binding protein (L-FABP) (5.9 ng/ml versus 3.9 ng/ml [P=0.001] and 3.2 ng/ml [P,0.001]) than did AKI-negative patients and healthy controls.Conclusions Novel urinary biomarkers remain elevated 7 years after an episode of CPB-AKI in children. However, there is no conventional evidence of CKD in these children. These biomarkers may be a more sensitive marker of chronic kidney injury after CPB-AKI. Future studies are needed to understand the clinical relevance of persistent elevations in IL-18, kidney injury molecule-1, and L-FABP in assessments for potential long-term kidney consequences of CPB-AKI.

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Section: Discussionsupporting

confidence: 91%

Follow-Up Renal Assessment of Injury Long-Term After Acute Kidney Injury (FRAIL-AKI)

Cooper

Claes

Goldstein

et al. 2016

Clinical Journal of the American Society of Nephrology

116

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“…The utility of urinary L-FABP in various chronic kidney disease (CKDs) has been reported. 31 A number of studies have suggested a possible role for urinary FABP in clinical diagnosis of renal disease. 32 Ferguson et al have reported a substantial increment of urinary L-FABP in several etiologies of acute kidney injury (AKI) such as acute tubular necrosis, nephrotoxic exposure, and sepsis.…”

mentioning

confidence: 99%

Urinary early kidney injury molecules in children with beta-thalassemia major

et al. 2015

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Background: The aim of this study was to investigate novel urinary biomarkers including N-acetyl-b-D-glucosaminidase (NAG), neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), and liver-type fatty acid binding protein (L-FABP) in children with b-thalassemia major (b-TM). Materials and methods: Totally, 52 patients (29 boys, 23 girls) with b-TM and 29 healthy controls (3-17 years) were included. Various demographic characteristics and blood transfusions/year, disease duration, and chelation therapy were recorded. Serum urea, creatinine, electrolytes, and ferritin and urinary creatinine, protein, calcium, phosphorus, sodium, potassium, and uric acid in first morning urine samples were measured and estimated glomerular filtration rate (eGFR) was calculated. Routine serum and urinary biochemical variables, urinary NAG to Creatinine (U NAG/Cr ), U NGAL/Cr , U KIM-1/Cr , and U L-FABP/Cr ratios were determined. Results: Patients had similar mean serum urea, creatinine and eGFR levels compared with controls (p40.05 for all). The mean urinary protein to creatinine (U Protein/Cr ) ratio was significantly higher in patients compared to the healthy subjects (0.13 ± 0.09 mg/mg and 0.07 ± 0.04 mg/mg, respectively; p50.001). Significantly increased U NAG/Cr (0.48 ± 0.58 vs. 0.23 ± 0.16, p ¼ 0.026) and U NGAL/Cr (22.1 ± 18.5 vs. 11.5 ± 6.17, p ¼ 0.01) ratios were found in b-TM patients compared with healthy controls. However, no differences were found in serum and urinary electrolytes or U KIM-1/Cr and U L-FABP/Cr ratios between patients and controls (p40.05). Significant correlations were found between urinary biomarkers and urinary electrolytes (p50.05). Conclusions: Our results suggest that urinary NAG and NGAL may be considered to be reliable markers to monitor renal injury in b-TM patients.

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“…10 Therefore, a biomarker that demonstrates the kidney injury in an earlier stage has been sought, and NGAL, NAG, and L-FABP have been demonstrated to reflect the renal damage in the early period. [19][20][21][22][23][24][25][26][27][28][29] NGAL, one of the members of lipocalin family with a 25 kDa molecular weight, is a protein in the small glycoprotein structure. It is released from renal tubular cells, hepatocytes, and endothelial cells as a response to cellular stress in certain conditions, such as ischemia and inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…26,27 Its excretion from the proximal tubule increases in tubulointerstitial damage. 28 The amount of urinary L-FABP has been found to increase in a short time after AKI in some conditions, such as acute tubular necrosis, sepsis, and cardiac surgery. 8,9,26,29 In a study in Japan, L-FABP levels were found to be positively correlated with the severity of renal ischemia.…”

Section: Discussionmentioning

confidence: 99%

Urinary kidney injury molecules in children with febrile seizures

et al. 2016

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Objective: Hypoxia occurs following convulsions, and hypoxia is one of the most common causes of acute renal damage. The aim of this study was to investigate urinary levels of kidney injury molecules, including neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-b-D-glucosaminidase (NAG), and liver-type fatty acid-binding protein (L-FABP) in children with febrile seizures (FS) for the first time. Methods: The study included 28 children with FS and 34 age and gender matched healthy children. Serum biochemistry and blood gases were measured in the serum samples. Estimated glomerular filtration rate (eGFR) was calculated. NGAL, NAG, L-FABP, and creatinine (Cr) were measured in the urine samples. The ratios of kidney injury markers to urinary Cr were used for comparisons.Results: There were no significant differences in eGFR and serum chemistry values between the FS and the control group (p > 0.05). Hypoxia was detected in 67.9% of the FS patients. The FS group had significantly higher urinary kidney injury molecules to Cr ratios compared to the controls, including NGAL/Cr (17.9 ± 9.8; 6.7 ± 4.0, respectively; p < 0.001), NAG/Cr (0.55 ± 0.29; 0.21 ± 0.16, p < 0.001), and L-FABP/Cr (4.85 ± 2.93; 1.74 ± 1.16, p < 0.001). Conclusion: Increased urinary NGAL/Cr, NAG/Cr, and L-FABP/Cr values, in patients with FS compared to healthy controls, suggest a possible subclinical renal damage in these patients. ARTICLE HISTORY

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Urinary liver-type fatty acid binding protein as a useful biomarker in chronic kidney disease

Abstract: Urinary excretion of L-FABP increases with the deterioration of renal function. Serum L-FABP did not influence on urinary L-FABP. Urinary L-FABP may be a useful clinical biomarker for monitoring CKD.

Cited by 154 publications

References 7 publications

Follow-Up Renal Assessment of Injury Long-Term After Acute Kidney Injury (FRAIL-AKI)

Follow-Up Renal Assessment of Injury Long-Term After Acute Kidney Injury (FRAIL-AKI)

Urinary early kidney injury molecules in children with beta-thalassemia major

Urinary kidney injury molecules in children with febrile seizures

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