Urinary liver-type fatty acid-binding protein for early detection of acute kidney injury in neonatal sepsis

Elnady, Hala G.; Abdalmoneam, Naglaa; Shady, Mones M. Abu; Hassanain, Amal I.; Ibraheim, R. A.; Raouf, Haiam Abdel

doi:10.1097/01.mjx.0000446938.48277.e6

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…In terms of L-FABP, Elnady et al (2014) carried out a case-control study including 42 newborns with sepsis and AKI in intensive care. Their uL-FABP levels were significantly higher than the levels observed in newborns without AKI 71 .…”

Section: Discussionmentioning

confidence: 54%

Use of non-conventional biomarkers in the early diagnosis of acute kidney injury in preterm newborns with sepsis

et al. 2022

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Acute kidney injury (AKI) is a common finding in Neotatal Intensive Care Units (NICU). Sepsis is one the main causes of AKI in preterm newborns. AKI has been associated with significant death rates. Early detection of the condition is the first step to improving prevention, treatment, and outcomes, while decreasing length of hospitalization, care costs, and morbimortality. AKI may progress to chronic kidney disease (CKD), a condition linked with dialysis and greater risk of cardiovascular disease. This review article aims to discuss cases of AKI in preterm newborns with sepsis, the use of biomarkers in lab workup, and the use of non-conventional biomarkers for the early identification of AKI.

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Section: Discussionmentioning

confidence: 54%

Use of non-conventional biomarkers in the early diagnosis of acute kidney injury in preterm newborns with sepsis

et al. 2022

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“…The performance of u-LFABP has shown promise in numerous clinical conditions. Elnaldy et al reported a significant positive correlation between u-LFABP and serum creatinine after 48 hours [ 25 ]. Another study also showed significant positive correlations between u-LFABP and %serum creatinine change at 2 hours (u-LFABP median 380 µ g/L), 6 hours (u-LFABP median 300 µ g/L), and 24 hours (u-LFABP median 160 µ g/L) post-cardiac surgery [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Point-of-Care (POC) Urinary L-Type Fatty Acid-Binding Protein (u-LFABP) Use in Critically Ill, Very Preterm Neonates

Puspitasari

Hidayati

Palupi-Baroto

et al. 2022

International Journal of Nephrology

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Preterm neonates are born with fewer functional nephrons, rendering them vulnerable to secondary insult. These insults are associated with acute kidney injury (AKI); thus, structural damage must be detected as early as possible. Urinary L-type fatty acid-binding protein (u-LFABP) has been proposed as a highly suitable kidney injury biomarker during prematurity. We aimed to analyze the use of POC u-LFABP in critically ill, very preterm neonates. This study was conducted at the neonatal intensive care unit (NICU), Dr. Cipto Mangunkusumo General Hospital, from November to December 2020. Baseline characteristics were recorded from electronic medical records. u-LFABP examination utilized stored urine samples from a previous study and was performed using a LFABP POC test kit. The proportion of abnormal u-LFABP (83.3%) was highest at 72 hours. Neonates with older gestational age (0–48 hours; p = 0.017 ) and higher birth weight (0–48 hours; p = 0.022 , 72 hours; p = 0.013 ) had normal u-LFABP levels. Neonates exposed to nephrotoxic agents showed higher proportion of abnormal u-LFABP (0–48 hours; p = 0.006 ). Longer invasive mechanical ventilation (IMV) period was observed in neonates with abnormal u-LFABP levels at 0–48 hours (7.44 ± 7.9 vs. 1.50 ± 2.9 days; p = 0.011 ). We found an association between complication rates and poorer disease outcome trends with abnormal u-LFABP; however, this relationship was not supported statistically. In conclusion, this study demonstrated that u-LFABP can be detected using bedside POC kit in critically ill very preterm neonates and those exposed to nephrotoxic agents may be at risk for kidney injury, confirmed by abnormal u-LFABP levels.

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Tubular and Glomerular Biomarkers of Acute Kidney Injury in Newborns

Kamianowska

Szczepański

Wasilewska

2019

CDM

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Background:Acute Kidney Injury (AKI) is a sudden decrease in kidney function. In the early period, the highest percentage of AKI occurs among newborns hospitalized in the neonatal intensive care units, especially premature neonates. The prognosis of AKI depends on the type and severity of the cause of an injury, the accuracy and the time of diagnosis and treatment. The concentration of serum creatinine is still the main diagnostic test, although it changes in the course of AKI later than glomerular filtration rate GFR. In addition, the reliability of the determination of creatinine level is limited because it depends on many factors. New studies have presented other, more useful laboratory markers of renal function that can be measured in serum and/or in urine.Objective:The aim of the work was to present the latest data about tubular and glomerular biomarkers of acute kidney injury in newborns.Methods:We undertook a structured search of bibliographic databases for peer-reviewed research literature by using focused review topics. According to the conceptual framework, the main idea of research literature has been summarized and presented in this study.Results:The concentrations of some novel biomarkers are higher in serum and/or urine of term and preterm newborns with AKI, especially in the course of perinatal asphyxia.Conclusion:In this systematic review of the literature, we have highlighted the usefulness of biomarkers in predicting tubular and/or glomerular injury in newborns. However, novel biomarkers need to prove their clinical applicability, accuracy, and cost-effectiveness prior to their implementation in clinical practice.

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Urinary liver-type fatty acid-binding protein for early detection of acute kidney injury in neonatal sepsis

Cited by 4 publications

References 22 publications

Use of non-conventional biomarkers in the early diagnosis of acute kidney injury in preterm newborns with sepsis

Use of non-conventional biomarkers in the early diagnosis of acute kidney injury in preterm newborns with sepsis

Point-of-Care (POC) Urinary L-Type Fatty Acid-Binding Protein (u-LFABP) Use in Critically Ill, Very Preterm Neonates

Tubular and Glomerular Biomarkers of Acute Kidney Injury in Newborns

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