Urinary Melatonin Excretion Throughout the Ovarian Cycle in Menstrually Related Migraine

Murialdo, Giovanni; Fonzi, S.; Costelli, P.; Solinas, Gian Piero; Parodi, Cristina; Marabini, S.; Fanciullacci, M; Polleri, A

doi:10.1046/j.1468-2982.1994.014003205.x

Cited by 70 publications

(47 citation statements)

References 25 publications

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“…Transient or permanent alteration of the TSH surge has been described in hypercortisolemia (26), critical illness (27-30), postoperative recovery (31), hyperglycemia (32), chronic renal failure (33,34), depression (35-38), and aging (39). None of these was present in the children studied in this project.…”

Section: Discussionmentioning

confidence: 81%

Isolated Central Hypothyroidism in Short Stature

Rose

1995

Pediatr Res

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Section: Discussionmentioning

confidence: 81%

Isolated Central Hypothyroidism in Short Stature

Rose

1995

Pediatr Res

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“…A phase shift in maximum melatonin levels was observed in 4 of 6 female sufferers of status migrainosus, compared to 9 controls [127]. Finally, a decrease in nocturnal urinary melatonin levels was reported in women suffering from migraine headaches related to their menstrual cycle [128,129].…”

Section: Can Melatonin Be a New Treatment For Migraine Headaches?mentioning

confidence: 84%

Prospects of the Clinical Utilization of Melatonin

Bubenik

Blask

Brown

et al. 1998

Biol Signals Recept

131

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This review summarizes the present knowledge on melatonin in several areas on physiology and discusses various prospects of its clinical utilization. Ever increasing evidence indicates that melatonin has an immuno-hematopoietic role. In animal studies, melatonin provided protection against gram-negative septic shock, prevented stress-induced immunodepression, and restored immune function after a hemorrhagic shock. In human studies, melatonin amplified the antitumoral activity of interleukin-2. Melatonin has been proven as a powerful cytostatic drug in vitro as well as in vivo. In the human clinical field, melatonin appears to be a promising agent either as a diagnostic or prognostic marker of neoplastic diseases or as a compound used either alone or in combination with the standard cancer treatment. Utilization of melatonin for treatment of rhythm disorders, such as those manifested in jet lag, shift work or blindness, is one of the oldest and the most successful clinical application of this chemical. Low doses of melatonin applied in controlled-release preparation were very effective in improving the sleep latency, increasing the sleep efficiency and rising sleep quality scores in elderly, melatonin-deficient insomniacs. In the cardiovascular system, melatonin seems to regulate the tone of cerebral arteries; melatonin receptors in vascular beds appear to participate in the regulation of body temperature. Heat loss may be the principal mechanism in the initiation of sleepiness caused by melatonin. The role of melatonin in the development of migraine headaches is at present uncertain but more research could result in new ways of treatment. Melatonin is the major messenger of light-dependent periodicity, implicated in the seasonal reproduction of animals and pubertal development in humans. Multiple receptor sites detected in brain and gonadal tissues of birds and mammals of both sexes indicate that melatonin exerts a direct effect on the vertebrate reproductive organs. In a clinical study, melatonin has been used successfully as an effective female contraceptive with little side effects. Melatonin is one of the most powerful scavengers of free radicals. Because it easily penetrates the blood-brain barrier, this antioxidant may, in the future, be used for the treatment of Alzheimer’s and Parkinson’s diseases, stroke, nitric oxide, neurotoxicity and hyperbaric oxygen exposure. In the digestive tract, melatonin reduced the incidence and severity of gastric ulcers and prevented severe symptoms of colitis, such as mucosal lesions and diarrhea.

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“…Serum melatonin levels are reduced in patients with cluster headache, particularly during a cluster period (Pringsheim et al, 2002). As regards plasma melatonin levels in migraine, the limited published data available derive from three small studies, the results of which suggested that female migraine sufferers have decreased nocturnal plasma melatonin levels both overall and during migraine attacks (Claustrat et al, 1989;Brun et al, 1995;Murialdo et al, 1994). Our study was not able to confirm these findings as we did not include a control group.…”

Section: Discussionmentioning

confidence: 68%

“…Since the pineal gland is considered to be a transducer of environmental stimuli into the neuroendocrine system, a pineal gland abnormality may be involved in headache etiology and homeostasis disruption. Levels of the pineal hormone melatonin have been found to be low in migraine (Claustrat et al, 1989;Murialdo et al, 1994;Brun et al, 1995) and in cluster headache (Leone et al,1995). Melatonin can act as a chronobiotic (being a circadian pacemaker of sleep) (Cajochen et al, 2003), an antioxidant, an antihypertensive, an anxiolytic and a sedative (Yousaf et al, 2010).…”

Section: Cognitive-motor Effects Of Treadmill Training In Pdmentioning

confidence: 99%

Melatonin 4 mg as prophylactic therapy for primary headaches: a pilot study

Bougea¹

2016

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Urinary Melatonin Excretion Throughout the Ovarian Cycle in Menstrually Related Migraine

Cited by 70 publications

References 25 publications

Isolated Central Hypothyroidism in Short Stature

Isolated Central Hypothyroidism in Short Stature

Prospects of the Clinical Utilization of Melatonin

Melatonin 4 mg as prophylactic therapy for primary headaches: a pilot study

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