2010
DOI: 10.1016/j.cca.2009.11.003
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Urinary metabonomic study on biochemical changes in chronic unpredictable mild stress model of depression

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Cited by 125 publications
(98 citation statements)
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“…These metabolites are uniquely produced by bacterial metabolism in the intestinal tract, indicating that MDD may be associated with variations in intestinal microflora. Accordingly, previous urinary metabonomic analysis in a depressed animal model has shown that depressed behavior is associated with changes in gut microflora (17). Interestingly, several clinical studies have demonstrated that MDD patients display a high comorbidity of irritable bowel syndrome (IBS) (40,41), a disorder involving gut microflora.…”
Section: Fig 2 Metabonomic Analysis Of Urine Samples From Mdd Subjementioning
confidence: 99%
“…These metabolites are uniquely produced by bacterial metabolism in the intestinal tract, indicating that MDD may be associated with variations in intestinal microflora. Accordingly, previous urinary metabonomic analysis in a depressed animal model has shown that depressed behavior is associated with changes in gut microflora (17). Interestingly, several clinical studies have demonstrated that MDD patients display a high comorbidity of irritable bowel syndrome (IBS) (40,41), a disorder involving gut microflora.…”
Section: Fig 2 Metabonomic Analysis Of Urine Samples From Mdd Subjementioning
confidence: 99%
“…[25][26][27] In the present research, a number of important serum and urinary metabolites altered contributing to a significantly different metabolic profile of the restraint stress group compared to the control after a period of restraint stress exposure. It was thus conceivable that restraint stress exposure probably caused systematic metabolic changes involving many metabolic pathways.…”
Section: Discussionmentioning
confidence: 93%
“…Evidence indicates that the levels of certain inflammatory mediators are higher in people with depression than other people (Liu et al, 2015). Some medicinal plants such as Danggui-Shaoyao-San and E. brevicornum exert antidepressant effects through reducing oxidative stress and inflammatory mediators (Zheng et al, 2010;Liu et al, 2015).…”
Section: Discussionmentioning
confidence: 99%
“…Depression-induced variations in these biomarkers may represent an association between depression and intestinal microflora metabolism (Ladep et al, 2006). Glutamic acid and amino butyric acid (GABA) serve as stimulatory and inhibitory neurotrans-mitters in mammalian brain and contribute significantly to mediating anxiety-and depression-associated behaviors (Zheng et al, 2010). …”
Section: Biomarkers To Study Depressionmentioning
confidence: 99%