Urinary MHPG sulfate as a marker of central norepinephrine metabolism: a commentary

Peyrin, L

doi:10.1007/bf01245022

Cited by 23 publications

(9 citation statements)

References 66 publications

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“…Although the mixed findings in the literature regarding the nature and existence of differences in either intake or symptomatology precluded extensive speculation about the underlying hormonal mechanisms, we also measured basal levels of cortisol and 3-methoxy-4-hydroxyphenylglycol (MHPG) in an effort to assess whether corticosteroid and/or central noradrenergic activity (using MHPG as a marker; Peyrin, 1990) were associated with menstrual phase, smoking condition (abstinence vs. ad lib smoking), and/or subsequent nicotine intake.…”

Section: Introductionmentioning

confidence: 99%

The effects of menstrual phase and nicotine abstinence on nicotine intake and on biochemical and subjective measures in women smokers: a A preliminary report

Pomerleau

García

Pomerleau

et al. 1992

Psychoneuroendocrinology

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Nicotine intake, menstrual and smoking withdrawal symptomatology, and baseline cortisol and MHPG were assessed in nine women smokers under conditions of ad lib smoking and overnight abstinence in three menstrual phases (early follicular, mid-to-late follicular, and late luteal). A trend towards higher nicotine intake (p < 0.10) was observed in the mid-to-late follicular phase. Although menstrual symptomatology was not significantly elevated during the smoking abstinence condition overall, abstinence appeared to prevent the normal reduction in symptomatology during the mid-to-late follicular phase that occurred under conditions of ad lib smoking. Menstrual and withdrawal symptoms were highly correlated, and both were most pronounced during the late luteal/abstinence condition. The smoking-specific item "craving" reflected this pattern, though in attenuated form, suggesting that the observed exacerbation of withdrawal symptomatology was not simply due to generalized dysphoria, as queried in both instruments. MHPG was significantly elevated in the late luteal phase, whereas cortisol was significantly higher during ad lib smoking than during abstinence and tended to be highest in the mid-to-late follicular phase. Further investigation will be needed to determine the functional significance of these findings for understanding and treating smoking in women.

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Section: Introductionmentioning

confidence: 99%

The effects of menstrual phase and nicotine abstinence on nicotine intake and on biochemical and subjective measures in women smokers: a A preliminary report

Pomerleau

García

Pomerleau

et al. 1992

Psychoneuroendocrinology

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“…After measurements of urinary free and total MHPG were discounted as markers of brain norepinephrine turnover, it was suggested that measurements of MHPG-sulfate might provide an alternative marker of central nervous system noradrenergic function (Filser et al, 1988;Peyrin, 1990). This was based on the premise that MHPG-glucuronide and MHPG-sulfate have different peripheral and central sources.…”

Section: Catecholamine Metabolismmentioning

confidence: 99%

Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine

2004

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“…Measurement of urinary 3-methoxy-4-hydroxyphenylglycol (MHPG), the main excretory product of norepinephrine, has been used as an index of the release of brain norepinephrine. Because MHPG is conjugated to MHPG-S in the central nervous system prior to excretion [ 13 ] we chose to analyze for only the conjugated MHPG-S in order to more specifically focus on brain norepinephrine activity.…”

Section: Introductionmentioning

confidence: 99%

A Phase 1 Trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion

et al. 2009

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BackgroundThe selective MAO-B inhibitor selegiline has been evaluated in clinical trials as a potential medication for the treatment of cocaine dependence. This study evaluated the safety of and pharmacologic interactions between 7 days of transdermal selegiline dosed with patches (Selegiline Transdermal System, STS) that deliver 6 mg/24 hours and 2.5 mg/kg of cocaine administered over 4 hours.MethodsTwelve nondependent cocaine-experienced subjects received deuterium-labeled cocaine-d5 intravenously (IV) 0.5 mg/kg over 10 minutes followed by 2 mg/kg over 4 hours before and after one week of transdermal selegiline 6 mg/24 hours. Plasma and urine were collected for analysis of selegiline, cocaine, catecholamine and metabolite concentrations. Pharmacodynamic measures were obtained.ResultsSelegiline did not change cocaine pharmacokinetic parameters. Selegiline administration increased phenylethylamine (PEA) urinary excretion and decreased urinary MHPG-sulfate concentration after cocaine when compared to cocaine alone. No serious adverse effects occurred with the combination of selegiline and cocaine, and cocaine-induced physiological effects were unchanged after selegiline. Only 1 peak subjective cocaine effects rating changed, and only a few subjective ratings decreased across time after selegiline.ConclusionNo pharmacological interaction occurred between selegiline and a substantial dose of intravenous cocaine, suggesting the combination will be safe in pharmacotherapy trials. Selegiline produced few changes in subjective response to the cocaine challenge perhaps because of some psychoactive neurotransmitters changing in opposite directions.

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Urinary MHPG sulfate as a marker of central norepinephrine metabolism: a commentary

Cited by 23 publications

References 66 publications

The effects of menstrual phase and nicotine abstinence on nicotine intake and on biochemical and subjective measures in women smokers: a A preliminary report

The effects of menstrual phase and nicotine abstinence on nicotine intake and on biochemical and subjective measures in women smokers: a A preliminary report

Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine

A Phase 1 Trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion

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