Urinary miR‐3137 and miR‐4270 as potential biomarkers for diabetic kidney disease

Li, Xiaoyu; Xu, Rong; Liu, Xiangyang; Xu, Ling; Xue, Mei; Cheng, Ying; Li, Ting; Yu, Xiaochen; Wang, Yue; Li, Chunjun; Sun, Bei; Chen, Liming

doi:10.1002/jcla.23549

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…Finally, the cell source of urinary miRNA can arise from any genitourinary tract, and the function of urinary miRNA is not necessarily the same as circulating ones. Sophisticated bioinformatics analysis and network interaction maps are capable of identifying Gene Ontology processes, classification and relevant pathways of target genes in this modern era [ 66 , 69 ]. These approaches may help to decipher the biological functions of urinary miRNA in the pathophysiology of DKD.…”

Section: Urinary Mirna Research: Human Evidencementioning

confidence: 99%

Urinary microRNA in Diabetic Kidney Disease: A Literature Review

et al. 2023

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Diabetic kidney disease is the most common primary disease of end-stage kidney disease globally; however, a sensitive and accurate biomarker to predict this disease remains awaited. microRNAs are endogenous single-stranded noncoding RNAs that have intervened in different post-transcriptional regulations of various cellular biological functions. Previous literatures have reported its potential role in the pathophysiology of diabetic kidney disease, including regulation of Transforming Growth Factor-β1-mediated fibrosis, extracellular matrix and cell adhesion proteins, cellular hypertrophy, growth factor, cytokine production, and redox system activation. Urinary microRNAs have emerged as a novel, non-invasive liquid biopsy for disease diagnosis. In this review, we describe the available experimental and clinical evidence of urinary microRNA in the context of diabetic kidney disease and discuss the future application of microRNA in routine practice.

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Section: Urinary Mirna Research: Human Evidencementioning

confidence: 99%

Urinary microRNA in Diabetic Kidney Disease: A Literature Review

et al. 2023

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“…miRNAs are emerging biomarkers of DKD, potentially important regulatory factors, and feasible targets for clinical diagnosis and therapeutic interventions (Alvarez and Distefano 2013). For example, urinary miR‐3137 and miR‐4270 have been described as potential biomarkers for DKD (Li et al 2020). In addition, urinary miR‐196a level is associated with the progression of kidney damage in patients with DN (An et al 2020).…”

Section: Cellular Crosstalk Of Podocytesmentioning

confidence: 99%

Cellular crosstalk of glomerular endothelial cells and podocytes in diabetic kidney disease

Jiang

Luo

Bai

et al. 2022

J. Cell Commun. Signal.

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Diabetic kidney disease (DKD) is a serious microvascular complication of diabetes and is the leading cause of end-stage renal disease (ESRD). Persistent proteinuria is an important feature of DKD, which is caused by the destruction of the glomerular filtration barrier (GFB). Glomerular endothelial cells (GECs) and podocytes are important components of the GFB, and their damage can be observed in the early stages of DKD. Recently, studies have found that crosstalk between cells directly affects DKD progression, which has prospective research significance. However, the pathways involved are complex and largely unexplored. Here, we review the literature on cellular crosstalk of GECs and podocytes in the context of DKD, and highlight specific gaps in the field to propose future research directions. Elucidating the intricates of such complex processes will help to further understand the pathogenesis of DKD and develop better prevention and treatment options.

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“…MiR-449a expression is reduced in CC and suppresses cell malignant behaviors [12] . Moreover, miR-3137 is a potential biomarkers for diabetic kidney disease [13] and its expression and role in cancers are still unclear.…”

Section: Microrna-3137/nuclear Protein Transcription Regulator 1 Axis...mentioning

confidence: 99%

MicroRNA-3137/Nuclear Protein Transcription Regulator 1 Axis Regulates Cervical Cancer Cells Proliferation Apoptosis and Autophagy by PI3K/AKT/mTOR pathway

Xing¹,

Zhang²,

Cai³

2022

IJPS

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Cervical cancer belongs to the second most frequent kind of cancer in female as well as a major cause of mortality in female all over the world. MicroRNAs are crucial modulators of multiple diseases. Based on GSE86100 database, microRNA-3137 expression was low in cervical cancer tissues and the difference was most significant, thus we further probed the potential along with mechanism of microRNA-3137 in cervical cancer cells. Reverse transcription-quantitative polymerase chain reaction together with Western blot was implemented for examining gene expression. 5-ethynyl-2'-deoxyuridine and flow cytometry analyses were adopted for assessing cervical cancer cells proliferation and apoptosis. Immunofluorescence was implemented to measure the fluorescence intensity of autophagy marker LC3II. Target scan together with luciferase reporter assay were implemented for confirming the direct binding of microRNA-3137 and nuclear protein transcriptional regulator 1. The results revealed that, microRNA-3137 was under expressed in cervical cancer cells. Overexpressed microRNA-3137 repressed cervical cancer cells proliferation while elevated cells apoptosis. Besides, nuclear protein transcriptional regulator 1 was directly targeted and negatively regulated by microRNA-3137 and was highly expressed in cervical cancer cells. Moreover, nuclear protein transcriptional regulator 1 silence promoted autophagy in cervical cancer cells and rescue assays further validated that the microRNA-3137/nuclear protein transcriptional regulator 1 axis suppressed cervical cancer cells proliferation while promoted cells apoptosis and autophagy through inactivation of the phosphatidylinositol-3-kinase/ protein kinase B/mammalian target of rapamycin pathway. Collectively, our study demonstrated that microRNA-3137/nuclear protein transcriptional regulator 1 axis affected cervical cancer cells proliferation, apoptosis, along with autophagy by means of inhibiting the phosphatidylinositol-3-kinase/protein kinase B/ mammalian target of rapamycin pathway, which may offer novel insights into the mechanism of cervical cancer progression as well as a novel therapy targeting for cervical cancer therapy. Key words: Cervical cancer, microRNA-3137, nuclear protein transcriptional regulator 1, autophagy, phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathwayThis is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms This article was originally published in a special issue, "Current Trends in Pharmaceutical and Biomedical Sciences"

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Urinary miR‐3137 and miR‐4270 as potential biomarkers for diabetic kidney disease

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 5 publications

References 38 publications

Urinary microRNA in Diabetic Kidney Disease: A Literature Review

Urinary microRNA in Diabetic Kidney Disease: A Literature Review

Cellular crosstalk of glomerular endothelial cells and podocytes in diabetic kidney disease

MicroRNA-3137/Nuclear Protein Transcription Regulator 1 Axis Regulates Cervical Cancer Cells Proliferation Apoptosis and Autophagy by PI3K/AKT/mTOR pathway

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