Urinary organophosphate metabolites and oxidative stress in children living in agricultural and urban communities

Sapbamrer, Ratana; Hongsibsong, Surat; Khacha-ananda, Supakit

doi:10.1007/s11356-020-09037-z

Cited by 13 publications

(6 citation statements)

References 44 publications

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“…This study suggests that children may be exposed to OPs both inside and outside the home and that this exposure can cause oxidative stress in children. Oxidative stress contributes to the development of chronic diseases and is recommended to be measured as a biomarker among children exposed to POs as a preventive way to identify chronic diseases ( 90 ).…”

Section: Resultsmentioning

confidence: 99%

Frequency of urinary pesticides in children: a scoping review

Guzman-Torres,

Sandoval-Pinto,

Cremades

et al. 2023

Front. Public Health

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Pesticides are any mix of ingredients and substances used to eliminate or control unwanted vegetable or animal species recognized as plagues. Its use has been discussed in research due to the scarcity of strong scientific evidence about its health effects. International literature is still insufficient to establish a global recommendation through public policy. This study aims to explore international evidence of the presence of pesticides in urine samples from children and their effects on health through a scoping review based on the methodology described by Arksey and O‘Malley. The number of articles resulting from the keyword combination was 454, and a total of 93 manuscripts were included in the results and 22 were complementary. Keywords included in the search were: urinary, pesticide, children, and childhood. Children are exposed to pesticide residues through a fruit and vegetable intake environment and household insecticide use. Behavioral effects of neural damage, diabetes, obesity, and pulmonary function are health outcomes for children that are commonly studied. Gas and liquid chromatography-tandem mass spectrometry methods are used predominantly for metabolite-pesticide detection in urine samples. Dialkylphosphates (DAP) are common in organophosphate (OP) metabolite studies. First-morning spot samples are recommended to most accurately characterize OP dose in children. International evidence in PubMed supports that organic diets in children are successful interventions that decrease the urinary levels of pesticides. Several urinary pesticide studies were found throughout the world's population. However, there is a knowledge gap that is important to address (public policy), due to farming activities that are predominant in these territories.

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Section: Resultsmentioning

confidence: 99%

Frequency of urinary pesticides in children: a scoping review

Guzman-Torres,

Sandoval-Pinto,

Cremades

et al. 2023

Front. Public Health

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“…Firstly, the concentration of herbicides from occupational exposure may not be high sufficient to generate ROS, so the level of ROS may not be enough to disrupt lipid of cell membrane. Secondly, anioxidant defenses in the body can reduce ROS and maintain redox homeostasis resulting in unchange the level of 8-isoprostane 25,26 .…”

Section: Discussionmentioning

confidence: 99%

Decreased Antioxidant Capacity in Corn Farmers Occupationally Exposed to the Mixture of Herbicides

Unchisa Intayoung,

Kanyapak Kohsuwan,

Klintean Wunnapuk

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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Background: The application of herbicides has been a common practice in worldwide agriculture, mainly with the goal to increase efficacy of weed control. So, most farmers faced a greater risk of herbicide exposure to develop adverse health effects from oxidative stress-induced herbicides. The aim of this study is to determine the urinary total antioxidant capacity (TAC) and 8-isoprostane levels in farmers using the

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“…In a 2022 study conducted in Spain, findings were consistent with the latest research, demonstrating that elevated levels of pyrethroid metabolite 3-PBA, and other metabolites such as malathion diacid (MDA), and ETU were linked to increased DNA methylation percentages at multiple CpG sites . The effect of pesticide residues on oxidative stress was also demonstrated by a study conducted in Thailand in 2020, where organophosphate metabolites (DAPs) were proved to cause oxidative stress . Children living in agricultural communities were found to have lower levels of glutathione (GSH), a vital antioxidant responsible for maintaining the body’s redox balance, compared to those residing in urban areas …”

Section: Urinary Biomarkers and Associated Health Risksmentioning

confidence: 99%

“…High urinary concentrations of DAPs were found in children living in farmworker houses than those living in nonfarmworker houses in the USA. 21 Samples collected from participants residing in agricultural areas showed higher detection frequencies and higher levels compared to those from urban areas, particularly for DAPs metabolites, according to a study conducted in Thailand, 96 as shown in Table 2. In the study done in the Czech Republic, during the summer, adults living in rural areas also had significantly higher levels in comparison to adults living in found no correlation between the levels of some urinary pesticides (e.g., tebuconazole) and the proximity to agricultural areas.…”

Section: Association Of Urinarymentioning

confidence: 99%

“…95 The effect of pesticide residues on oxidative stress was also demonstrated by a study conducted in Thailand in 2020, where organophosphate metabolites (DAPs) were proved to cause oxidative stress. 96 Children living in agricultural communities were found to have lower levels of glutathione (GSH), a vital antioxidant responsible for maintaining the body's redox balance, compared to those residing in urban areas. 96 7.3.…”

Section: Lactating Mothersmentioning

confidence: 99%

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A Comprehensive Review on Pesticide Residues in Human Urine

Hakme,

Poulsen,

Lassen

2024

J. Agric. Food Chem.

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Numerous studies worldwide have evaluated pesticide residues detected in urine. This review serves as a contribution to this field by presenting an overview of scientific research studies published from 2001 to 2023, including details of study characteristics and research scope. Encompassing 72 papers, the review further delves into addressing key challenges in study design and method used such as sampling and analytical approaches, results adjustments, risk assessment, estimations, and results evaluation. The review explores urinary concentrations and detection frequency of metabolites of organophosphates and pyrethroids, as well as herbicides such as 2,4-D and glyphosate and their metabolites, across various studies. The association of the results with demographic and lifestyle variables were explored. While farmers generally have higher pesticide exposure, adopting organic farming practices can reduce the levels of pesticides detected in their urine. Residence close to agricultural areas has shown high exposure in some cases. Dietary exposure is especially high among people adopting a conventionally grown plant-rich dietary pattern. A higher detection level and frequency of detection are generally found in females and children compared to males. The implications of transitioning to organic and sustainable plant-rich diets for reducing pesticide exposure and potential health benefits for both adults and children require further investigation.

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Urinary organophosphate metabolites and oxidative stress in children living in agricultural and urban communities

Cited by 13 publications

References 44 publications

Frequency of urinary pesticides in children: a scoping review

Frequency of urinary pesticides in children: a scoping review

Decreased Antioxidant Capacity in Corn Farmers Occupationally Exposed to the Mixture of Herbicides

A Comprehensive Review on Pesticide Residues in Human Urine

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