Urinary pathogens and drug susceptibility patterns of urinary tract infections among antenatal clinic attendees in Ibadan, Nigeria

Kehinde, Aderemi; Adedapo, Kayode Solomon; Aimakhu, Chris; Odukogbe, Akin‐Tunde A.; Olayemi, Oladapo; Bl, Salako

doi:10.1111/j.1447-0756.2011.01635.x

Cited by 7 publications

(9 citation statements)

References 7 publications

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“…Two of them reported on Proteus spp. (19,20). Both studies presented the susceptibility of P. mirabilis separately from that of P. vulgaris.…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies reported on Enterobacteriaceae other than E. coli and Klebsiella spp. or on the total number of isolates of Enterobacteriaceae included in a study (19,20,25,31,(33)(34)(35)(36)38). Two of them reported on Proteus spp.…”

Section: Resultsmentioning

confidence: 99%

“…In 13 studies, the antimicrobial susceptibility was defined according to the Clinical and Laboratory Standards Institute guidelines (11,12,16,17,20,22,23,(27)(28)(29)(30)(31)(32), while in 10 other studies the guidelines of the Comité de l' Antibiogramme de la Société Française de Microbiologie were used (13-15, 24-26, 33-36). The susceptibility breakpoints that were used were not provided in 5 studies (18,19,21,37,38). Seventeen of the included studies had a prospective nature (12, 16-19, 21-23, 26, 27, 29-32, 35, 37, 38), while 11 had a retrospective nature (11, 13-15, 20, 25, 28, 33, 34, 36).…”

Section: Resultsmentioning

confidence: 99%

“…The antimicrobial susceptibility data reported on Ͼ1,000 isolates of Enterobacteriaceae for the following countries: South Africa (358,930) (11,12), Tunisia (8,890) (13)(14)(15), Nigeria (3,070) (16)(17)(18)(19)(20)(21)(22)(23), and Senegal (2,102) (24)(25)(26). In 13 studies, the antimicrobial susceptibility was defined according to the Clinical and Laboratory Standards Institute guidelines (11,12,16,17,20,22,23,(27)(28)(29)(30)(31)(32), while in 10 other studies the guidelines of the Comité de l' Antibiogramme de la Société Française de Microbiologie were used (13-15, 24-26, 33-36).…”

Section: Resultsmentioning

confidence: 99%

“…The antimicrobial susceptibility of Klebsiella species isolates was reported in 6 studies (19,20,23,25,35,38) and varied at the following rates: amoxicillin-clavulanic acid, 0 to 69%; cefotaxime, 43 to 100%; ceftazidime, 40 to 100%; imipenem, 100%; ciprofloxacin, 53 to 100%; nalidixic acid, 51 to 94%; gentamicin, 60 to 100%; amikacin, 100%; trimethoprimsulfamethoxazole, 0 to 56%; nitrofurantoin, 40 to 78%; tetracycline, 43 to 69%; and fosfomycin, 100%.…”

Section: Resultsmentioning

confidence: 99%

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Evaluation of Antimicrobial Susceptibility of Enterobacteriaceae Causing Urinary Tract Infections in Africa

Tansarli

Athanasiou

Falagas

2013

Antimicrob Agents Chemother

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dOur objective was to evaluate the antimicrobial susceptibility of Enterobacteriaceae causing urinary tract infections (UTIs) in adults in Africa. The PubMed database was systematically searched to identify relevant studies published after 2000. Google, World Health Organization, and African Field Epidemiology networks were also searched. Twenty-eight studies, accounting for 381,899 urine isolates from 14 African countries, met the inclusion criteria. Escherichia coli, Klebsiella spp., and Proteus spp. were the most commonly encountered uropathogens. Cefotaxime, imipenem, fosfomycin, and ciprofloxacin were the antibiotics with the highest activity against E. coli isolates from outpatients, with susceptibility being 92 to 99, 100, 100, and 68 to 91%, respectively. The susceptibility among Klebsiella spp. isolates from outpatients varied from 80 to 100% for amikacin and from 53 to 100% for ciprofloxacin, while susceptibility was 74 to 78, 97, and 77% for ciprofloxacin, amikacin, and fosfomycin, respectively, among Klebsiella species isolates from inpatients or patients with hospital-acquired UTIs. With regard to Proteus spp., the highest activity was observed among fluoroquinolones; 71 to 100% of the P. mirabilis isolates were susceptible to ciprofloxacin in four studies, and 74 to 100% of the P. vulgaris isolates were susceptible to ofloxacin in two studies. The currently available evidence suggests that the antimicrobial susceptibility patterns of Enterobacteriaceae uropathogens in African countries were similar to those in countries of southeast Europe. Further original studies are warranted from African countries for which there is limited published data.

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“…Two of them reported on Proteus spp. (19,20). Both studies presented the susceptibility of P. mirabilis separately from that of P. vulgaris.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of Antimicrobial Susceptibility of Enterobacteriaceae Causing Urinary Tract Infections in Africa

Tansarli

Athanasiou

Falagas

2013

Antimicrob Agents Chemother

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A systematic review and meta-analysis on the prevalence of Escherichia coli and extended-spectrum β-lactamase-producing Escherichia coli in pregnant women

Moradi

Eshrati

Motevalian

et al. 2021

Arch Gynecol Obstet

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Antimicrobial resistance in West Africa: a systematic review and meta-analysis

Bernabé

Langendorf²,

Ford

et al. 2017

International Journal of Antimicrobial Agents

125

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Growing data suggest that antimicrobial-resistant bacterial infections are common in low- and middle-income countries. This review summarises the microbiology of key bacterial syndromes encountered in West Africa and estimates the prevalence of antimicrobial resistance (AMR) that could compromise first-line empirical treatment. We systematically searched for studies reporting on the epidemiology of bacterial infection and prevalence of AMR in West Africa within key clinical syndromes. Within each syndrome, the pooled proportion and 95% confidence interval were calculated for each pathogen-antibiotic pair using random-effects models. Among 281 full-text articles reviewed, 120 met the eligibility criteria. The majority of studies originated from Nigeria (70; 58.3%), Ghana (15; 12.5%) and Senegal (15; 12.5%). Overall, 43 studies (35.8%) focused on urinary tract infections (UTI), 38 (31.7%) on bloodstream infections (BSI), 27 (22.5%) on meningitis, 7 (5.8%) on diarrhoea and 5 (4.2%) on pneumonia. Children comprised the majority of subjects. Studies of UTI reported moderate to high rates of AMR to commonly used antibiotics including evidence of the emergence of cephalosporin resistance. We found moderate rates of AMR among common bloodstream pathogens to typical first-line antibiotics including ampicillin, cotrimoxazole, gentamicin and amoxicillin/clavulanate. Among S. pneumoniae strains isolated in patients with meningitis, levels of penicillin resistance were low to moderate with no significant resistance noted to ceftriaxone or cefotaxime. AMR was common in this region, particularly in hospitalized patients with BSI and both outpatient and hospitalized patients with UTI. This raises concern given the limited diagnostic capability and second-line treatment options in the public sector in West Africa.

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Urinary pathogens and drug susceptibility patterns of urinary tract infections among antenatal clinic attendees in Ibadan, Nigeria

Abstract: In conclusion, the incidence of culture-positive urinary tract infection in pregnancy is common in Ibadan. More studies are needed to evaluate the susceptibility profile of uropathogens to commonly used antibiotics in our environment.

Cited by 7 publications

References 7 publications

Evaluation of Antimicrobial Susceptibility of Enterobacteriaceae Causing Urinary Tract Infections in Africa

Evaluation of Antimicrobial Susceptibility of Enterobacteriaceae Causing Urinary Tract Infections in Africa

A systematic review and meta-analysis on the prevalence of Escherichia coli and extended-spectrum β-lactamase-producing Escherichia coli in pregnant women

Antimicrobial resistance in West Africa: a systematic review and meta-analysis

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