Urinary procollagen III aminoterminal propeptide and β-catenin – New diagnostic biomarkers in solitary functioning kidney?

Taranta-Janusz, Katarzyna; Moczulska, Anna; Nosek, Hanna; Michaluk-Skutnik, Joanna; Klukowski, Mark; Wasilewska, Anna

doi:10.1016/j.advms.2018.10.002

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…In that study, Ghoul et al ( 31 ) documented that a higher urinary PIIINP/creatinine ratio (UPIIINP/Cr) was associated with lower eGFR values, higher CKD stage, and greater interstitial renal fibrosis determined by kidney histology. Subsequently, other studies showed that higher PIIINP levels, both in urine and serum, were associated with increasing stages of CKD and with interstitial renal fibrosis in both adults and children ( 32 , 33 ). According with these findings, we have shown that higher levels of plasma PIIINP were strongly associated with lower eGFR values in our children with NAFLD, even if the strength of this association was slightly lower than that observed for HA.…”

Section: Discussionmentioning

confidence: 97%

Higher Levels of Plasma Hyaluronic Acid and N-terminal Propeptide of Type III Procollagen Are Associated With Lower Kidney Function in Children With Non-alcoholic Fatty Liver Disease

et al. 2022

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ObjectiveHyaluronic acid (HA) and N-terminal propeptide of type III procollagen (PIIINP) are two non-invasive biomarkers of liver fibrosis in non-alcoholic fatty liver disease (NAFLD). We examined the relationships of plasma levels of HA and PIIINP with kidney function in children with NAFLD.MethodsPlasma HA and PIIINP levels were measured using two commercially available enzyme-linked immunosorbent assay kits in a cohort of 106 Caucasian overweight or obese children with biopsy-proven NAFLD. Glomerular filtration rate (eGFR) was estimated using the Bedside Schwartz equation. Genotyping for the patatin-like phospholipase domain-containing protein-3 (PNPLA3) rs738409 variant was performed using an allelic discrimination assay.ResultsChildren with fibrosis F2 had significantly higher plasma PIIINP and HA levels than those with F0 or F1 fibrosis. Liver fibrosis was positively associated with plasma HA and PIIINP, as well as with the presence of the risk allele G of PNPLA3 rs738409 variant, and negatively with eGFR. Moreover, eGFR showed significant inverse associations with HA and PIIINP levels, as well as the presence of G of PNPLA3 rs738409, and liver fibrosis stage. Notably, our multivariable regression models showed that higher plasma PIIINP (standardized beta coefficient: −0.206, P = 0.011) and HA levels (standardized beta coefficient: −0.531, P < 0.0001) were associated with lower eGFR values, even after adjustment for age, sex, systolic blood pressure, PNPLA3 rs738409 genotype, and any stage of liver fibrosis.ConclusionsHigher levels of HA and PIIINP were associated with lower eGFR values in Caucasian children with biopsy-proven NAFLD, independently of PNPLA3 rs738409 genotype and other potential confounding factors.

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Section: Discussionmentioning

confidence: 97%

Higher Levels of Plasma Hyaluronic Acid and N-terminal Propeptide of Type III Procollagen Are Associated With Lower Kidney Function in Children With Non-alcoholic Fatty Liver Disease

et al. 2022

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“…It also correlated with more intense interstitial fibrosis in the biopsies of the kidney with CKD [ 109 ] and was a marker of CKD progression in renal transplant recipients [ 110 ]. The study by Taranta-Janusz et al showed that children with solitary functioning kidneys (SFK) had significantly higher urinary PIIINP than healthy controls [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Protein Biomarkers in Chronic Kidney Disease in Children—What Do We Know So Far?

Szumińska

Wasilewska

Kamianowska

2023

JCM

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Chronic kidney disease (CKD) in children is a major concern of medical care and public health as it is related to high morbidity and mortality due to progression to end-stage kidney disease (ESKD). It is essential to identify patients with a risk of developing CKD to implement therapeutic interventions. Unfortunately, conventional markers of CKD, such as serum creatinine, glomerular filtration rate (GFR) and proteinuria, have many limitations in serving as an early and specific diagnostic tool for this condition. Despite the above, they are still the most frequently utilized as we do not have better. Studies from the last decade identified multiple CKD blood and urine protein biomarkers but mostly assessed the adult population. This article outlines some recent achievements and new perspectives in finding a set of protein biomarkers that might improve our ability to prognose CKD progression in children, monitor the response to treatment, or even become a potential therapeutic target.

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“…The slightly progressive deterioration of renal function over time is mainly due to reduced nephron endowment resulting in glomerular hyperfiltration and subsequent hyperperfusion injury of glomeruli [ 3 , 4 ]. However, in recent years, the influence of other factors in renal function decline in individuals with SFK has also been emphasized [ 5 , 6 ]. Currently, the available methods, including estimated glomerular filtration rate (eGFR), renal nuclear scans, or ultrasonography, do not allow for early detection of renal impairment, and these are not good predictors of the future course of kidney disease.…”

Section: Introductionmentioning

confidence: 99%

Galectin-3—A New Player of Kidney Damage or an Innocent Bystander in Children with a Single Kidney?

Latoch

Konończuk

Jander

et al. 2021

JCM

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The aim of this study was to evaluate the galectin-3 (Gal-3) level in children with a congenital solitary functioning kidney (cSFK) and determine its association with common renal function parameters. The study consisted of 68 children (49 males) with cSFK. We demonstrated that children with cSFK had a lower level of galectin-3 than that of healthy subjects (p < 0.001). No significant differences in serum cystatin C (Cys C) levels between the cSFK children and the reference group were found. The subjects with cSFK and reduced estimated glomerular filtration rate (eGFR) had significantly higher levels of Gal-3 and Cys C compared to those with normal eGFR (p < 0.05). Children with eGFR <60 mL/min/1.73 m2 showed significant statistical differences between the values of area under ROC curve (AUC) for Gal-3 (AUC 0.91) and Cys C (AUC 0.96) compared to that for creatinine level (AUC 0.76). Similar analyses carried out among cSFK children with eGFR <90 mL/min/1.73 m2 revealed an AUC value of 0.69 for Gal-3, 0.74 for Cys C, and 0.64 for creatinine; however, no significant superiority was shown for any of them. The receiver operating characteristic (ROC) analyses for identifying the SFK children among all participants based on the serum levels of Gal-3 and Cys C did not show any diagnostic profile (AUCs for Gal-3 and Cys C were 0.22 and 0.59, respectively). A positive correlation between the Gal-3 and Cys C concentrations was found (r = 0.39, p = 0.001). We demonstrated for the first time that Gal-3 might play an important role in the subtle kidney damage in children with cSFK. However, further prospective studies are required to confirm the potential applicability of Gal-3 as an early biomarker for kidney injury and possible progression to CKD.

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Urinary procollagen III aminoterminal propeptide and β-catenin – New diagnostic biomarkers in solitary functioning kidney?

Cited by 3 publications

References 26 publications

Higher Levels of Plasma Hyaluronic Acid and N-terminal Propeptide of Type III Procollagen Are Associated With Lower Kidney Function in Children With Non-alcoholic Fatty Liver Disease

Higher Levels of Plasma Hyaluronic Acid and N-terminal Propeptide of Type III Procollagen Are Associated With Lower Kidney Function in Children With Non-alcoholic Fatty Liver Disease

Protein Biomarkers in Chronic Kidney Disease in Children—What Do We Know So Far?

Galectin-3—A New Player of Kidney Damage or an Innocent Bystander in Children with a Single Kidney?

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