Urinary protein:creatinine ratio in rabbits in relation to their serological status to <i>Encephalitozoon cuniculi</i>

Reusch, Brigitte; Murray, Jane; Papasouliotis, Kostas; Redrobe, Sharon

doi:10.1136/vr.164.10.293

Cited by 18 publications

(27 citation statements)

References 17 publications

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“…Specific antibodies develop within 21 days post-infection (11,33). In clinically healthy rabbits, the present study showed that the seropositivity rate for E. cuniculi infection was 49.5%, which is similar to rates (50-53%) of infection in previous studies (6,14,20), although it is higher than the rates of infection reported in some (4,13,17,26,28,(30)(31)(32). In contrast, in the current study, the seropositivity rate of the disease was lower than those previously reported (71-93%) in various countries (3,10,21,37).…”

Section: Discussionsupporting

confidence: 83%

Relationship between seropositivity of Encephalitozoon cuniculi and renal biochemical markers in clinically healthy rabbits

Özkan¹,

Yücesan²,

Pekkaya³

et al. 2019

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Encephalitozoon cuniculi can cause latent disease, especially in lagomorphs and many wild and domestic animals in various countries. This infection is important for veterinary and public health because it is caused by a potentially zoonotic and opportunistic pathogen. The aim of this study was to investigate the relationship between seropositivity of E. cuniculi and renal function markers, which may be useful in predicting the disease in clinically healthy rabbits. In this study, the seropositivity of E. cuniculi infection in clinically healthy rabbits was determined, and necropsy findings were evaluated along with the results of renal function tests. In a laboratory rabbit breeding facility, enzyme-linked immunosorbent assay (ELISA) tests showed that 48 (49.5%) of 97 rabbits were seropositive against E. cuniculi. Blood urea nitrogen (BUN) and creatinine levels were significantly elevated in seropositive animals. Two seropositive rabbits were necropsied to confirm the infection. According to histopathological findings in the kidney, degenerative changes and E. cuniculi spores were identified in the tubule epithelia. Serum creatinine (p<0.001) and BUN (p<0.01) levels were found to have a statistically significant relationship with the serological status of rabbits. Serological and histopathological methods are not routinely used in rabbits to diagnose E. cuniculi infection. The kidneys were one of the most affected organs in encephalitozoonosis in rabbits. As revealed in this study, the testing blood urea nitrogen and creatinine levels would be useful for the evaluation of general health status and renal function of the seropositive rabbits, and clinical interpretation as well.

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Section: Discussionsupporting

confidence: 83%

Relationship between seropositivity of Encephalitozoon cuniculi and renal biochemical markers in clinically healthy rabbits

Özkan¹,

Yücesan²,

Pekkaya³

et al. 2019

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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“…UPCR was fivefold the upper value reported for the species (2.14, reference range 0.11–0.4), but the γ-GT index was within normal limits (Reusch and others 2009, Mancinelli and others 2012). …”

Section: Investigationsmentioning

confidence: 58%

Diagnostic challenges and surgical treatment of hydroureteronephrosis in a rabbit (Oryctolagus cuniculus)

Tahas

Pope

Denk³

et al. 2017

Vet Record Case Reports

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A two-and-half-year-old male neutered rabbit was referred for investigation of intermittent urinary disease of 13 months in duration. Case work-up led to the diagnosis of unilateral hydroureteronephrosis following obstructive ureterolithiasis. The establishment of contralateral kidney function before ureteronephrectomy constituted a particular diagnostic challenge. This was assessed by a combination of imaging, serum biochemistry, urine protein to creatinine ratio and γ-glutamyltransferase index. Ureteronephrectomy was subsequently performed, with initial remission of all clinical signs. However, an adhesion of mesenteric adipose tissue to the caecum was identified and resected following frequent re-presentation. At the time of submission (800 days following initial surgery), the rabbit was still alive and healthy. The successful outcome may indicate a more favourable prognosis for rabbits with unilateral ureteronephrolithiasis and/or hydroureteronephrosis than is historically proposed.

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“…Bisher gibt es nur wenige Daten für Kaninchen und Nager. Werte von gesunden Kaninchen lagen, vergleichbar zu Kleintieren, im Bereich von 0,11-0,40 [37]. Rasse, Körpergewicht, Geschlecht und Haltung der Kaninchen hatten keinen Einfluss auf die UPC.…”

Section: Urin-protein-kreatinin-ratio (Upc)unclassified

Azotämien bei Kaninchen und Nagern – ein Update

Müller

2019

Tierarztl Prax Ausg K

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ZusammenfassungEine eingeschränkte Ausscheidung harnpflichtiger Stoffe aus dem Körper und ein daraus resultierender Konzentrationsanstieg dieser Stoffe im Blut (Azotämie) tritt auch bei Kaninchen und Nagern regelmäßig auf. Neben Nierenerkrankungen können prärenale und postrenale Ursachen eine Azotämie zur Folge haben. Eine systematische Abklärung von Patienten mit erhöhter Konzentration der harnpflichtigen Stoffe im Blut ist zwingend notwendig, um eine Diagnose stellen und eine gezielte Therapie einleiten zu können. Der Artikel gibt einen Überblick über Diagnose und Therapie häufiger Azotämieursachen bei Kaninchen und Nagern.

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Urinary protein:creatinine ratio in rabbits in relation to their serological status to Encephalitozoon cuniculi

Cited by 18 publications

References 17 publications

Relationship between seropositivity of Encephalitozoon cuniculi and renal biochemical markers in clinically healthy rabbits

Relationship between seropositivity of Encephalitozoon cuniculi and renal biochemical markers in clinically healthy rabbits

Diagnostic challenges and surgical treatment of hydroureteronephrosis in a rabbit (Oryctolagus cuniculus)

Azotämien bei Kaninchen und Nagern – ein Update

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