Urinary rubidium in breast cancers

Su, Yi; Chen, Lijuan; He, Jianxing; Yuan, Xue-Jiao; Cen, Yu-Ling; Su, Fengxi; Tang, Lu-Ying; Zhang, Aihua; Chen, Weiqing; Lin, Ying; Wang, Shenming; Ren, Ze-Fang

doi:10.1016/j.cca.2011.08.035

Cited by 27 publications

(11 citation statements)

References 34 publications

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“…A total of 240 breast cancer cases and 246 control subjects were included in the analyses. Demographic characteristics and breast cancer related factors for the study population were reported elsewhere [30]. Breast cancer patients, as compared with similarly aged controls, were more likely to be premenopausal, nulliparous, and low educated.…”

Section: Resultsmentioning

confidence: 97%

Joint effects between urinary selenium and polymorphisms in methylation related genes on breast cancer risk

Lin¹,

Cen²,

Lin³

et al. 2015

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The aim of this study was to explore the associations of urinary selenium and polymorphisms in methylation related genes with breast cancer risk and the interactions on the risk. The present study involved in 240 female patients with incident breast cancer and 246 age-matched controls in two affiliated hospitals of Sun Yat-sen University in Guangzhou, China, from October 2009 to July 2010. DNMT1 rs2228611, MTHFR rs1801133, and MTR rs1805087 were genotyped using a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry platform. Urinary concentration of selenium was measured by inductively coupled plasma mass spectrometry. Women with urinary selenium in the second tertile had a significant reduced breast cancer risk compared to those with urinary selenium in the lowest tertile [OR (95%CI): 0.50 (0.30, 0.81)]. DNMT1 rs2228611, MTHFR rs1801133, and MTR rs1805087 were not associated with breast cancer risk. Women with the third tertile of urinary selenium had a significant reduced breast cancer risk compared to those with the lowest tertile among women only with CC genotype [OR (95%CI): 0.55 (0.30, 1.00)] but not CT/TT genotypes [OR (95%CI): 1.58 (0.73, 3.42)] of MTHFR rs1801133 (P for interaction=0.044). Our results suggested that selenium was associated with a decreased risk of breast cancer and this beneficial effect was limited to women with CC genotype of MTHFR rs1801133.

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Section: Resultsmentioning

confidence: 97%

Joint effects between urinary selenium and polymorphisms in methylation related genes on breast cancer risk

Lin¹,

Cen²,

Lin³

et al. 2015

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“…The determination of the content of elements in organs is one of the methods for assessing the state of nutrition and animal exposition to the environment. Rubidium absorption in mammals takes place through the alimentary tract because that element is present in the air, soil, water, plants, and the tissues of living organisms, thus, passing through all links of the food chain (2,20). Rubidium is assimilated quickly and effectively but its elimination is slow (1).…”

Section: Discussionmentioning

confidence: 99%

“…It was noted that its level in the tumour tissue was significantly higher as compared to the healthy gland tissue. This suggests that it may be connected with the pathogenesis and development of neoplasms (6,8,15,16,20).…”

mentioning

confidence: 99%

Evaluation of Rubidium Contents in Organs of Bitches (Canis Lupus F. Familiaris)

Skibniewska

Kosla

Skibniewski

2012

Bulletin of the Veterinary Institute in Pulawy

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The objective of the presented study was to compare rubidium concentration in different organs of bitches, depending on their health state. Samples of muscles, liver, and kidneys collected post mortem from 45 animals, at the age of 1-8 years, were examined. Chemical analysis was conducted using the inductively coupled plasma atomic emission spectroscopy method. The contents of rubidium in particular organs varied from 2.07 to 4.52, from 1.25 to 3.81, and from 1.32 to 3.78 mg·kg-1 of wet weight for muscle, kidney, and liver samples, respectively. The highest values were observed in animals with neoplastic disease and the lowest in healthy animals. These differences were highly statistically significant.

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“…The statuses of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) for breast cancer were determined by pathologists using immunohistochemistry tests. The definitions of statuses of these 3 hormonal receptors were previously described in detail (Su et al, 2011). Informed consent was obtained from all the study participants, and the Ethical Committee of the School of Public Health at Sun Yat-sen University approved the study.…”

Section: Study Populationmentioning

confidence: 99%

“…In addition, assessment of breast cancer risk is still a challenge and environmental biomarkers may be the hope for this challenge (Cazzaniga et al, 2009;Su et al, 2011;Lin et al, 2012). Given that cesium normally exists in human body and is excreted mainly through urine (Ghosh et al, 1993), it would be meaningful to compare cesium levels in urine samples between cancer patients and normal controls for evaluating its anticancer efficacy and application as a biomarker of the risk assessment.…”

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confidence: 99%