Association of Urinary Cesium with Breast Cancer Risk

Qin, Ya-Chao; Tang, Lu-Ying; Su, Yi; Chen, Lijuan; Su, Fengxi; Lin, Ying; Zhang, Aihua; Ren, Ze-Fang

doi:10.7314/apjcp.2014.15.22.9785

Cited by 6 publications

(1 citation statement)

References 28 publications

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“…as biomarkers for cancer development in liver, prostate and lung cancer (11,(23)(24)(25). Cadmium (Cd), lead (Pb), mercury (Hg) and tin (Sn) were reported to be toxic because they can mimic or block the functions of other essential metals (26).…”

Section: Evaluation Of Heavy Metals and Metabolites In The Urine Of Pmentioning

confidence: 99%

Evaluation of heavy metals and metabolites in the urine of patients with breast cancer

Men

Zhang

et al. 2019

Oncol Lett

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Epidemiologic studies demonstrated that the environment serves a crucial role in cancer development. Heavy metals, including arsenic (As), cadmium (cd), chromium (Cr), lead and mercury, are considered to be carcinogens or co-carcinogens. Furthermore, Cd has been detected in breast cancer (BC) tissue at high concentrations. The present study aimed to investigate the correlation between heavy metals detected in urine and urine metabolome of patients with BC, and their association with cancer development. Nuclear magnetic resonance was used to determine urine metabolites and an inductively coupled plasma mass spectrometry system was used to detect heavy metals in urine samples. The results demonstrated that Cd was markedly increased in the urine of patients with BC compared with the control population (approximately 2-fold). Cr and As were also increased in the urine of patients with BC. In addition, numerous small molecule metabolites were altered in the urine of patients with BC compared with the control population. This study also demonstrated that alterations in small molecule metabolites in the urine of patients with BC were very similar to results from a previous report. These findings indicated that environmental exposure to Cd, As, or Cr could influence the urine levels of metabolites, which may be involved in BC development. Further investigation is therefore required to examine a larger range of samples from different countries or areas in order to understand the impact of heavy metals on metabolism and BC development.

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Section: Evaluation Of Heavy Metals and Metabolites In The Urine Of Pmentioning

confidence: 99%

Evaluation of heavy metals and metabolites in the urine of patients with breast cancer

Men

Zhang

et al. 2019

Oncol Lett

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Cohort profile: Guangzhou breast cancer study (GBCS)

Wang,

Li,

Xiao

et al. 2024

Eur J Epidemiol

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The Guangzhou Breast Cancer Study (GBCS) is a patient-based prospective cohort study designed to identify risk factors and underlying mechanisms for breast cancer (BC) incidence and prognosis, specifically addressing the need for individualized prevention in South China, where BC incidence is notably high. Based in Guangzhou, China, the GBCS began recruitment in 2008, comprises three complementary studies: the Guangzhou breast cancer cohort with 5471 breast cancer patients, a case–control study with 1551 cases and 1605 controls, and an immunohistochemistry (IHC) cohort with 1063 breast cancer patients. Participants are primarily aged 41–60 years. Cohort follow-up is conducted every three months in the first year, every six months in the second and third years, and annually thereafter. High follow-up rates have been achieved until 2023, with 73.5% for the Guangzhou breast cancer cohort and 98.6% for the IHC cohort still active. Baseline data collection included demographic characteristics and breast cancer risk factors, while follow-up data included survival, treatment details, disease history, occupational history, post-diagnostic lifestyle, and laboratory measures, including genetic markers, proteins, and environmental exposures. The study encourages global collaborations and invites interested researchers to contact the corresponding author at xulin27@ mail.sysu.edu.cn with specific research ideas or proposals.

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