Urinary Stone Composition in Israel: Current Status and Variation with Age and Sex—A Bicenter Study

Usman, Kalba D.; Golan, Shay; Abdin, Tamer; Livne, Pinhas M.; Pode, Dov; Duvdevani, Mordechai; Lifshitz, David A.

doi:10.1089/end.2013.0236

Cited by 16 publications

(12 citation statements)

References 17 publications

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“…We found that calcium oxalate stones (90.1% vs 86.9%, P < .001) were more common in men, while calcium phosphate (12.3% vs 9.1%, P < .001), struvite (4.1% vs 2.6%, P < .001), and cystine stones (3.2% vs 2.5%, P < .003) were more common in women. Similar findings were also observed in various stone composition studies 25,26 . Lieske et al found more calcium phosphate (25.0% vs 9.6%) and struvite stones (4.6% vs 1.8%) in women than in men, and more calcium oxalate (74.1% vs 58.1%) and uric acid stones (10.3% vs 5.5%) in men 25 .…”

Section: Discussionsupporting

confidence: 77%

The stone crescent of Anatolia

et al. 2021

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Objectives To assess the largest stone composition data available and to present the variations in the stone composition according to gender and different climatic environments in Turkey. Methodology Data for a total of 24 768 urinary stone patients from the Turkish Mineral Research and Exploration Institute were evaluated. X‐ray diffraction crystallography was used for analysis and the Köppen‐Trewartha classification was used to assess the climatic features of the cities. After the assessment, the cities were divided into two groups—those with a continental climate (Dc) were defined as inland areas and the others (Non‐Dc) were defined as coastal areas. Results The male‐to‐female ratio was 2.2:1. Amongst the patients, 53.7% had pure stones, while 46.3% had mixed‐type stones. The most common type of stone was calcium oxalate in both pure and mixed stone groups. Given the climate patterns, the stone ratio between regions with a Dc climate and a Non‐Dc climate was approximately 2:3. Cystine and uric acid stones were observed more frequently in inland regions, while calcium oxalate, whewellite, and struvite stones were observed more frequently in coastal areas (P = .005, P < .001, P < .001, P = .002, P = .002, respectively). Calcium oxalate stones were found at a higher rate in men, while cysteine, struvite, and calcium phosphate stones were more common in women (P < .001, P = .003, P < .001, P < .001, respectively). Conclusion This study provides the most comprehensive data on the stone disease in Turkey. Considering the distribution of stone disease in Turkey, the frequency of analysed stones had parallels with the temperature averages and climate features, presenting crescent‐like distribution.

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Section: Discussionsupporting

confidence: 77%

The stone crescent of Anatolia

et al. 2021

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“…It is widely accepted that urinary stones are more common in men than women, with a male:female ratio range of 1.4–2.9% . Males are at high risk of kidney stones overall, possibly because of a greater tendency for urine CaOx oversaturation and a high protein diet that favours CaOx supersaturation .…”

Section: Discussionmentioning

confidence: 99%

The status and characteristics of urinary stone composition in China

Zeng

Yang

et al. 2020

BJU International

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Epidemiology ObjectivesTo explore characteristics of urinary stone composition in China, and determine the effects of gender, age, body mass index (BMI), stone location, and geographical region on stone composition. Patients and methodsWe prospectively used Fourier-transform infrared spectroscopy to analyse stones from consecutive patients presenting with new-onset urolithiasis at 46 hospitals in seven geographical areas of China, between 1 June 2010 and 31 May 2015. Chi-squared tests and logistic regression analyses were used to determine associations between stone composition and gender, age, BMI, stone location, and geographical region. ResultsThe most common stone constituents were: calcium oxalate (CaOx; 65.9%), carbapatite (15.6%), urate (12.4%), struvite (2.7%), and brushite (1.7%). CaOx and urate stones occurred more frequently in males, whereas carbapatite and struvite were more common in females (P < 0.01). CaOx and carbapatite were more common in those aged 30-50 and 20-40 years than in other groups. Brushite and struvite were most common amongst those aged <20 and >70 years. The detection rate of urate increased with age, whilst cystine decreased with age. Obese patients were more likely to have urate stones than carbapatite or brushite stones (P < 0.01). CaOx, carbapatite, brushite, and cystine stones were more frequently found in the kidney than other types, whereas urate and struvite were more frequent in the bladder (P < 0.01). Stone composition varied by geographical region. ConclusionsThe most common stone composition was CaOx, followed by carbapatite, urate, struvite, and brushite. Stone composition differed significantly in patients grouped by gender, age, BMI, stone location, and geographical region.

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“…Historically, USD was three times more common among men (23). Recent investigations suggest a decreasing disease excess in men (1,2,24).…”

Section: Sexmentioning

confidence: 99%

“…Stone composition may also vary by age and sex. Women have fewer calcium oxalate monohydrate stones and more struvite and calcium phosphate stones (23,26). Uric acid stones are more likely in men and the elderly (26).…”

Section: Sexmentioning

confidence: 99%

Urinary Stone Disease: Advancing Knowledge, Patient Care, and Population Health

Scales

Tasian

Schwaderer

et al. 2016

CJASN

138

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Expanding epidemiologic and physiologic data suggest that urinary stone disease is best conceptualized as a chronic metabolic condition punctuated by symptomatic, preventable stone events. These acute events herald substantial future chronic morbidity, including decreased bone mineral density, cardiovascular disease, and CKD. Urinary stone disease imposes a large and growing public health burden. In the United States, 1 in 11 individuals will experience a urinary stone in their lifetime. Given this high incidence and prevalence, urinary stone disease is one of the most expensive urologic conditions, with health care charges exceeding $10 billion annually. Patient care focuses on management of symptomatic stones rather than prevention; after three decades of innovation, procedural interventions are almost exclusively minimally invasive or noninvasive, and mortality is rare. Despite these advances, the prevalence of stone disease has nearly doubled over the past 15 years, likely secondary to dietary and health trends. The NIDDK recently convened a symposium to assess knowledge and treatment gaps to inform future urinary stone disease research. Reducing the public health burden of urinary stone disease will require key advances in understanding environmental, genetic, and other individual disease determinants; improving secondary prevention; and optimal population health strategies in an increasingly cost-conscious care environment.

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Urinary Stone Composition in Israel: Current Status and Variation with Age and Sex—A Bicenter Study

Cited by 16 publications

References 17 publications

The stone crescent of Anatolia

The stone crescent of Anatolia

The status and characteristics of urinary stone composition in China

Urinary Stone Disease: Advancing Knowledge, Patient Care, and Population Health

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