Urinary Tamm-Horsfall Protein Excretion in Patients with Primary Vesicoureteral Reflux

Uto, Iwao; Ishimatsu, Takashi; Hirayama, Hideo; Ueda, Shoichi; Nishi, Kazuhiko; Tsuruta, Junji; Kambara, Takeshi

doi:10.1159/000473650

Cited by 5 publications

(3 citation statements)

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“…Of these patients, 80% had VUR in the graft and a history of urinary tract infections [240]. In a study of 26 consecutive patients with primary VUR, low urinary uromodulin excretion was associated with decreased kidney function [241].…”

Section: Vesicoureteral Refluxmentioning

confidence: 99%

Unveiling the Hidden Power of Uromodulin: A Promising Potential Biomarker for Kidney Diseases

Thielemans,

Speeckaert,

Delrue

et al. 2023

Diagnostics

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Uromodulin, also known as Tamm-Horsfall protein, represents the predominant urinary protein in healthy individuals. Over the years, studies have revealed compelling associations between urinary and serum concentrations of uromodulin and various parameters, encompassing kidney function, graft survival, cardiovascular disease, glucose metabolism, and overall mortality. Consequently, there has been a growing interest in uromodulin as a novel and effective biomarker with potential applications in diverse clinical settings. Reduced urinary uromodulin levels have been linked to an elevated risk of acute kidney injury (AKI) following cardiac surgery. In the context of chronic kidney disease (CKD) of different etiologies, urinary uromodulin levels tend to decrease significantly and are strongly correlated with variations in estimated glomerular filtration rate. The presence of uromodulin in the serum, attributable to basolateral epithelial cell leakage in the thick ascending limb, has been observed. This serum uromodulin level is closely associated with kidney function and histological severity, suggesting its potential as a biomarker capable of reflecting disease severity across a spectrum of kidney disorders. The UMOD gene has emerged as a prominent locus linked to kidney function parameters and CKD risk within the general population. Extensive research in multiple disciplines has underscored the biological significance of the top UMOD gene variants, which have also been associated with hypertension and kidney stones, thus highlighting the diverse and significant impact of uromodulin on kidney-related conditions. UMOD gene mutations are implicated in uromodulin-associated kidney disease, while polymorphisms in the UMOD gene show a significant association with CKD. In conclusion, uromodulin holds great promise as an informative biomarker, providing valuable insights into kidney function and disease progression in various clinical scenarios. The identification of UMOD gene variants further strengthens its relevance as a potential target for better understanding kidney-related pathologies and devising novel therapeutic strategies. Future investigations into the roles of uromodulin and regulatory mechanisms are likely to yield even more profound implications for kidney disease diagnosis, risk assessment, and management.

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Section: Vesicoureteral Refluxmentioning

confidence: 99%

Unveiling the Hidden Power of Uromodulin: A Promising Potential Biomarker for Kidney Diseases

Thielemans,

Speeckaert,

Delrue

et al. 2023

Diagnostics

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“…It is believed to accumulate from leakage of adjacent ruptured tubules [17]. Interestingly, in a study on children with surgically corrected VUR but no improvement on renal function postoperatively, THP levels remained elevated before and after surgery [18]. Still a lot of research has to be undertaken to minimize or hopefully abandon the burden of one of the widest used imaging modalities in pediatric urology.…”

Section: Conclusion and Future Modalitiesmentioning

confidence: 99%

Radiation Safety and Future Innovative Diagnostic Modalities

Radmayr

2008

Advances in Urology

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One must demand an accurate, safe, radiation-free, and noninvasive method for reflux examination as the ideal possibility for reflux screening. Of course the available different imaging modalities are far from this ideal situation, but minimal radiation exposure is indeed a permanent objective. Additionally since all of these studies might be quite stressful to the child and the family, a specially designed and equipped environment is obligatory for the comfort of all involved. An absolute ideal modality in the diagnosis of VUR would be the definition of a certain marker in serum or urine that could identify children with VUR without the need for any interventional screening modality. Therefore more and more efforts have to be made in the future to investigate different markers for this purpose. Since reflux is one of the most frequent congenital conditions pediatric urologist have to deal with potential risks that might lead to renal insufficiency, noninvasive and radiation-free modalities should become the methods of choice, hopefully in the near future.

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“…In all fact that THP was measured in urine samples previstudy subjects, net gastrointestinal absorption of alkali ously stored at −20°C. This has been shown to pro-(GI-Alkali, expressed in mEq/day) was derived from excreduce wide variations in results, whereas measurements tion rates of non-combustible cations and anions according in samples stored at −70°C or in fresh urines produce to the formula results with constant reproducibility [18].…”

mentioning

confidence: 99%

Determinants of urinary excretion of Tamm–Horsfall protein in non‐selected kidney stone formers and healthy subjects

Glauser¹,

Hochreiter²,

Jaeger³

et al. 2000

Nephrology Dialysis Transplantation

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Both in C and SF, urinary THP excretion is related to body size, renal function and urinary citrate excretion, whereas dietary habits apparently do not affect THP excretion. Uric acid and calcium stone formation predict reduced THP excretion in comparison with C, whereas female gender goes along with increased urinary THP excretion in C. Possibly most relevant to kidney stone formation is the fact that THP excretion rises only in C in response to increasing urinary calcium and oxalate concentrations, whereas this self-protective mechanism appears to be missing in SF.

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Urinary Tamm-Horsfall Protein Excretion in Patients with Primary Vesicoureteral Reflux

Cited by 5 publications

References 0 publications

Unveiling the Hidden Power of Uromodulin: A Promising Potential Biomarker for Kidney Diseases

Unveiling the Hidden Power of Uromodulin: A Promising Potential Biomarker for Kidney Diseases

Radiation Safety and Future Innovative Diagnostic Modalities

Determinants of urinary excretion of Tamm–Horsfall protein in non‐selected kidney stone formers and healthy subjects

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