Urinary tract infection and autoimmune diseases

Matas, Ana; Xipell, Marc; Bodro, Marta; Cervera, Ricard; Quintana, Luís F.

doi:10.1016/b978-0-444-64217-2.00003-8

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…Immune-altered conditions discussed in this review are four groups ( Figure 2 ), (i) Autoimmune diseases, (ii) immunodeficiencies (iii) Cancer ( Shurin and Smolkin, 2007 ), and (iv) immune therapy-associated immune system disorders ( Aiyegbusi et al., 2022 ). UTIs are strongly associated with immune-mediated diseases and can result in death from an overwhelming infection ( Wu et al., 2016 ; Matas et al., 2020 ; Sime et al., 2020 ). Indeed, several studies have reported urobiome dysbiosis in these diseases or disorders ( Liu et al., 2017 ; Shrestha et al., 2018 ; Mansour et al., 2020 ; Liu et al., 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Urine microbiome in individuals with an impaired immune system

Elsayed,

Wolfe,

Burk

2024

Front. Cell. Infect. Microbiol.

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With the advent of next generation sequencing, it is now appreciated that human urine is not sterile. Recent investigations of the urinary microbiome (urobiome) have provided insights into several urological diseases. Urobiome dysbiosis, defined as non-optimal urine microbiome composition, has been observed in many disorders; however, it is not clear whether this dysbiosis is the cause of urinary tract disorders or a consequence. In addition, immunologically altered disorders are associated with higher rates of urinary tract infections. These disorders include immunoproliferative and immunodeficiency diseases, cancer, and immunosuppressant therapy in transplant recipients. In this review, we examine the current state of knowledge of the urobiome in immunologically altered diseases, its composition and metabolomic consequences. We conclude that more data are required to describe the urobiome in immune altered states, knowledge that could facilitate understanding the role of the urobiome and its pathophysiological effects on urinary tract infections and other disorders of the urinary tract.

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Section: Introductionmentioning

confidence: 99%

Urine microbiome in individuals with an impaired immune system

Elsayed,

Wolfe,

Burk

2024

Front. Cell. Infect. Microbiol.

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“…Cystitis is characterized by the presence of bacteriuria. These bacteria cause complaints of dysuria, frequency, or urinary urgency in the absence of pyelonephritis criteria 8 . Properly treating UTIs can make the disease easy to manage and prevent further episodes 9 .…”

Section: Introductionmentioning

confidence: 99%

The Role of Probiotics in Urinary Tract Infections in Women

Kurniawati,

Gatut Hardianto,

Tri H. S. Hadi

et al. 2023

Indones J Obstet Gynecol

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Objective: To review the role of probiotics in urinary tractinfections in womenMethods: Systematic review was conducted by searchingfi ve databases with several keywords, namely “urinary tractinfection”, “cystitis”, “women” and “probiotics”. Articles thathave gone through peer review are included in the studyif they meet the inclusion and exclusion criteria. Reportingfollows the PRISMA rules.Results: The women included in this study varied from earlyadulthood to postmenopausal, most of whom were sexuallyactive, used birth control methods, and had recurrenturinary tract infections. The results showed that the use ofprobiotics in varied outcomes, either positive or not showedsignifi cant results. This is also due to the differences in theoutcomes studied and the additional materials used. Thisalso contributed to the emergence of adverse effects.Conclusion: The use of probiotics in the treatment ofcystitis and urinary tract infections has hope, although notall studies show signifi cant results. The side effects foundare still tolerable although they need to be considered.Keywords: cystitis, probiotic, urinary tract infection, women.AbstrakTujuan: Meninjau peran probiotik dalam infeksi salurankemih pada perempuan.Metode: Tinjauan sistematis dilakukan dengan mencari limadatabase dengan beberapa kata kunci, yaitu “infeksi salurankemih”, “sistitis”, “perempuan” dan “probiotik”. Artikel yangtelah melalui peer review diikutsertakan dalam penelitianjika memenuhi kriteria inklusi dan eksklusi. Pelaporanmengikuti aturan PRISMA.Hasil: Perempuan yang diikutsertakan dalam penelitian inibervariasi mulai dari dewasa awal hingga pascamenopause,sebagian besar aktif secara seksual, menggunakan metodekontrasepsi, dan mengalami infeksi saluran kemih berulang.Hasil penelitian menunjukkan bahwa penggunaan probiotikpada infeksi saluran kemih menunjukkan hasil yang positifmaupun tidak menunjukkan hasil yang signifi kan. Hal inijuga disebabkan perbedaan outcome dan bahan tambahanyang digunakan. Penggunaan bahan juga berkontribusipada munculnya efek samping.Kesimpulan: Penggunaan probiotik dalam pengobatansistitis dan infeksi saluran kemih memiliki harapan, walaupuntidak semua penelitian menunjukkan hasil yang signifi kan.Efek samping yang ditemukan masih dapat ditoleransimeskipun perlu diperhatikan.Kata kunci: infeksi saluran kemih, perempuan, probiotik,sistitis.

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