Urinary Tract Infection in Patients with Diabetes Mellitus

Alrwithey, Faisal Abdullah; Alahmadi, Abdullah Eid Ayyadah; Shehri, Ali Al; Abalhassan, Ibrahim Abdullah; Alhamad, Fatimah Mohammed Salman; Khedher, Yousef Zaki; Aldehry, Alaa Mohammed; Beig, Shaima Tariq Mansoor; Althubyani, Awatif Ahmed; Ghamdi, Reham Ahmed Al

doi:10.12816/0041071

Cited by 5 publications

(5 citation statements)

References 16 publications

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“…This is in consistence with the finding of a study that was carried out as systematic review on observational studies by evaluating 37 articles. [ 17 ] All kidney and urinary tract related diseases also had UTI, which was prominent in our study.…”

Section: Discussionmentioning

confidence: 65%

Bacteria causing urinary tract infections and its antibiotic susceptibility pattern at tertiary hospital in Al-Baha region, Saudi Arabia: A retrospective study

2020

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A BSTRACT Context: Clinicians face one of the most common bacterial infections in developing countries that is urinary tract infection (UTI). Current knowledge on antimicrobial susceptibility pattern is essential for selecting appropriate therapy. Aims: In this study, we investigated the various bacteria causing UTI and determined the sensitivity and resistance of antibiotics pattern against most prevalent uropathogens isolated from patients at tertiary hospital, Al-Baha, Saudi Arabia. Settings and Design: This was a retrospective study of urine culture conducted in King Fahad Hospital at Al-Baha in Saudi Arabia. Materials and Methods: Laboratory reports and patient medical files of both inpatient and outpatient were collected between June 2017 and May 2018, targeting both male and female of age above 18 years of age, who had been treated for UTI. Results: A total of 349 patients’ urine report was studied to identify the uropathogens. Escherichia coli was the main etiologic agent in community and hospital-acquired infections. The majority of the bacteria was isolated from female (60%), whereas the remaining (40%) was from male. The most common isolates were E. coli, Klebsiella pneumoniae, Enterococcus faecalis, E. coli Extended spectrum beta-lactamases , Pseudomonas , and K. pneumoniae ESBL (these represented 37.82%, 19.20%, 10.89%, 10.32%, 6.59%, and 3.72%, of isolate, respectively). UTI due to E. coli was at a higher rate during summer than during winter. This study showed that ciprofloxacin (20.29%) and cefuroxime (16.14%) are most prescribed medications, followed by ceftriaxone (12.96%) and then tazocin (8.80%). Imipenem, meropenem, amikacin, vancomycin, tigecycline, linezolid, and colistin were highly sensitive for most types of bacteria, but gram-negative bacteria were highly resistant to ampicillin. Gram-positive bacteria showed highly resistance to cefoxitin. Conclusion: The microbial culture and sensitivity of the isolates from urine samples should be carried out as a routine before starting the antimicrobial therapy. Current knowledge of the antibiotic sensitivity/resistance patterns of uropathogens at a particular geographical region is a guiding factor for choosing an appropriate empirical antimicrobial treatment rather than following universal guidelines.

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Section: Discussionmentioning

confidence: 65%

Bacteria causing urinary tract infections and its antibiotic susceptibility pattern at tertiary hospital in Al-Baha region, Saudi Arabia: A retrospective study

2020

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“…Patients with diabetes are at high risk of urinary tract infections (UTI) and its complications especially in patients with Type-2 diabetes. A survey reported UTI to be the most common microbial infection worldwide 4. Globally, it was estimated about 150 million people each year affected from this infection.…”

Section: Introductionmentioning

confidence: 99%

“…Similarly risk of UTI increases with age, poor metabolic control, various impairments in the immune system and incomplete bladder emptying due to autonomic neuropathy 6,7. The most contributed pathogen of UTIs is Escherichia coli in diabetic and non diabetic patients and others are Klebsiella pneumonia (K.pn), Staphylococcus saprophyticus, Proteus mirabilis, Enterococcus faecalis, Group-B Streptococcus, Pseudomonas aeruginosa, Candida spp, and Staphylococcus aureus 4. The microbes causing infection differ in their susceptibility towards antimicrobial drugs from place to place 6,10.…”

Section: Introductionmentioning

confidence: 99%

Frequency of urinary tract infection and antibiotic sensitivity of uropathogens in patients with diabetes

Zubair¹,

Shah²,

Fawwad

et al. 2019

Pak J Med Sci

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Objective:To determine the frequency of urinary tract infections and antibiotic sensitivity among patients with diabetes.Methods:This observational study was carried out in Microbiology Department of Baqai Institute of Diabetology and Endocrinology (BIDE), Baqai Medical University from April 2015 to June 2016. All patients with diabetes having symptoms of UTI attending out patients department of BIDE were analyzed. All samples received in the laboratory were processed according to Clinical and Laboratory Standards Institute (CLSI) guidelines. Antimicrobial susceptibility pattern was determined by disc diffusion method.Results:A total number of 199 urine specimens, frequency of UTI were 24 (12.06%) in male and 175 (87.94%) in female. UTIs were highly found in (age group 51-60) 70 (35.18%). Escherichia coli was the most frequent pathogen (71%), followed by Klebsiellapneumoniae (7.48%), Proteus mirabilis (1.87%), Staphylococcus aureus (9.35%), Candida (5.61%) and Candidaalbicans were (2.80%). Majority of gram negative uropathogens were shown high sensitivity towards Imipenem and Piperacillin / Tazobactam followed by Nitrofurantion, Ceftriaxone, Levofloxacin, Ofloxacine, Ciprofloxacin, Norfloxacin, Cefixime, Nalidixic acid and Cephradine. Gram positive was most sensitive to Nitrofurantionand Vancomycin followed by Piperacillin / Tazobactam, Imipenem, Cephradine, Ceftriaxone, Norfloxacin and Cefixime.Conclusion:We observed the higher frequency of UTIs in female as compared to male participants due to poor hygiene. E.coli was the most frequent pathogen responsible for UTI in patients with diabetes, followed by Staphylococcus aureus.

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“…Meanwhile, antibiotic sensitivity is a primary concern in the treatment of patients with infection. Patients with diabetes are prone to have an infection, commonly urinary tract infection because of the impaired immune response, dysfunctional bladder, and other mechanisms (Alrwithey et al 2017). Other studies demonstrated that diabetic patients with urinary tract infections are vulnerable to have resistant pathogens as the causative agent (Nitzan et al 2015).…”

Section: Discussionmentioning

confidence: 99%

Antibiotic Sensitivity Pattern of Bacterial Isolates among Diabetic Outpatients with Urinary Tract Infection in Pontianak

2020

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Diabetic patients are associated with a higher risk of infection. The research purposed to identify antibiotic susceptibility patterns among diabetic outpatients with urinary tract infection in Pontianak. An experimental study was performed for 13 bacterial isolates of diabetic outpatients with urinary tract infection in the Clinic of Diabetes Mellitus, Sultan Syarif Mohamad Alkadrie Hospital, Pontianak. The disc diffusion method was used to perform the susceptibility of antibiotics to the bacterial isolates. Among 13 isolates, the most common causative agent of urinary tract infection was Escherichia coli (53.85%), followed by Pseudomonas aeruginosa (30.77%). Klebsiella spp and Enterobacter aerogenes were 7.69%. Most isolates of bacteria of the study had a high sensitivity to Cefepime (92.31%), then followed by Levofloxacin, Amikacin, and Meropenem for 84.62%. The study revealed low sensitivity of bacteria to Amoxicillin/Clavulanate, Co-Trimoxazole, Cefazoline and Ceftriaxone (30.77%, 23.08 %, 23.08%, 23.08%, respectively). All bacterial isolates had high resistance to Ampicillin. Moreover, multidrug resistance observed among bacterial isolates. Keywords: antibiotic susceptibility, diabetes, urinary tract infections

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Urinary Tract Infection in Patients with Diabetes Mellitus

Cited by 5 publications

References 16 publications

Bacteria causing urinary tract infections and its antibiotic susceptibility pattern at tertiary hospital in Al-Baha region, Saudi Arabia: A retrospective study

Bacteria causing urinary tract infections and its antibiotic susceptibility pattern at tertiary hospital in Al-Baha region, Saudi Arabia: A retrospective study

Frequency of urinary tract infection and antibiotic sensitivity of uropathogens in patients with diabetes

Antibiotic Sensitivity Pattern of Bacterial Isolates among Diabetic Outpatients with Urinary Tract Infection in Pontianak

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