Urinary tract infections and reduced risk of bladder cancer in Los Angeles

Abstract

We investigated the association between urinary tract infections (UTIs) and transitional cell carcinoma of the bladder in a populationbased case -control study in Los Angeles covering 1586 cases and age-, gender-, and race-matched neighbourhood controls. A history of bladder infection was associated with a reduced risk of bladder cancer among women (odds ratio (OR), 0.66; 95% confidence interval (CI), 0.46 -0.96). No effect was found in men, perhaps due to power limitations. A greater reduction in bladder cancer risk was observed among women with multiple infections (OR, 0.37; 95% CI, 0.18 -0.78). Exclusion of subjects with a history of diabetes, kidney or bladder stones did not change the inverse association. A history of kidney infections was not associated with bladder cancer risk, but there was a weak association between a history of other UTIs and slightly increased risk among men. Our results suggest that a history of bladder infection is associated with a reduced risk of bladder cancer among women. Cytotoxicity from antibiotics commonly used to treat bladder infections is proposed as one possible explanation.

Diabetes and risk of bladder cancer: a study using the National Health Insurance database in Taiwan

“…Furthermore, consistent with the risk factors described in other studies [8][9][10][11][12], age, male sex, urinary tract infection or stones, and nephropathy were significant risk factors (Tables 1 and 2). A recent population-based matched case-control study performed in the USA suggested a reduced risk of bladder cancer in women, but not in men, with a history of urinary tract infection [13]. Actually, when men and women were analysed separately, nephropathy and urinary tract diseases including infection and stones remained significant in both sexes (data not shown).…”

“…The discrepancy between men and women in the study performed in the USA and between the study performed in the USA and the present study is attributable to the inherent limitations of the case-control design of the USA study or to the different ethnicities of the individuals in the respective studies. Therefore the lower risk in the US women with urinary tract infection [13] requires confirmation.…”

Role of Bacteria in Oncogenesis

“…It is possible that the association, if it exists, is limited to squamous cell carcinomas only and that including transitional cell carcinomas in the analyses obscures the findings through misclassification. Potential confounders such as the antitumor effects of NSAIDs or antibiotics used by patients may also need to be assessed (125).…”

Role of Urinary Tract Bacterial Infection in the Process of Bladder Carcinogenesis (Molecular and Biochemical Studies)

“…4,5 In Egypt, carcinoma of the bladder is the most prevalent cancer, accounting for as many as 31% of all cancer cases. Currently, it ranks first in males representing 16.2 % of male cancer.…”