Urine methylmalonic acid measurements for the assessment of cobalamin deficiency related to neuropsychiatric disorders

Gültepe, Mustafa; Özcan, Ömer; Avşar, Kadir; Çetin, Mesut; Özdemir, Ayşegül; Gok, Muslum

doi:10.1016/s0009-9120(03)00033-x

Cited by 24 publications

(23 citation statements)

References 14 publications

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“…Since uMMA measurements are normalized for creatinine concentration and this is a non-invasive method, this may offer a new method of analysis for vitamin B 12 . 10,11 In our study, we observed that uMMA levels in infants had a wider range than the normal range reported in children (2.0 -5.1 mmol/mol creatinine) and adults (0.7 -3.2 mmol/mol creatinine). 13 In addition, in contrast to studies reporting a higher uMMA concentration in infants receiving mother's milk compared with those on formula, our data revealed that uMMA was unrelated to the mode of nutrition.…”

Section: Discussioncontrasting

confidence: 45%

Vitamin B₁₂, Folate, Homocysteine and Urinary Methylmalonic Acid Levels in Infants

et al. 2007

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Serum vitamin B 12 and folate, and their functional markers, plasma homocysteine and urinary methylmalonate (uMMA) were measured in 204 healthy, term infants at birth, and at 2 and 6 months. Compared with infants receiving formula food, those fed mother's milk had lower vitamin B 12 and folate at 2 and 6 months. In infants receiving mother's milk, vitamin B 12 levels were similar at birth (238 pg/ml) and 2 months (243 pg/ml), whereas with formula milk the level was significantly higher at 2 months (558 pg/ml) than at birth (257 pg/ml). Vitamin B 12 was negatively correlated with homocysteine at birth and 6 months. The level of uMMA (mmol/mol creatinine) was higher at 2 (mother's milk, 25.5; formula, 23.97) and 6 months (19.77; 15) than at birth (11.97; 10.88), and was not correlated with vitamin B 12 levels. Homocysteine may be a reliable marker of vitamin B 12 status in neonates and infants; however, uMMA is not suitable as a marker of vitamin B 12 status.

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Section: Discussioncontrasting

confidence: 45%

Vitamin B₁₂, Folate, Homocysteine and Urinary Methylmalonic Acid Levels in Infants

et al. 2007

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“…Thus, urine MMA measurements may provide more valuable information than serum vitamin B 12 , and urine MMA measurements can show whether vitamin B 12 has entered a cell (23). Another study showed that, in association with one-carbon metabolism, although erythrocyte membrane phosphatidylcholine concentrations were lower than in a control group, phosphatidylethanolamine concentrations were higher in schizophrenic patients because of impaired phospholipid methylation (51).…”

Section: Psychosis (Schizophrenia)mentioning

confidence: 99%

Folate and homocysteine metabolisms and their roles in the biochemical basis of neuropsychiatry

Coşar¹,

İpçioğlu²,

Özcan³

et al. 2014

Turk J Med Sci

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This work aims to study recent climatic oscillations and their influence on sedimentation in the Ria de Vigo, a coastal embayment in Galicia, NW Spain. It is based on the study of clay mineral assemblages, in conjunction with other proxies (granulometric, geochemical, geochronological and microfaunal), in the core KSGX 24. A Benthic Foraminifera High Productivity (BFHP) proxy was used to determine changes in the flux of organic matter (OM) at the bottom of the study area. Total organic carbon (TOC) content is not a suitable proxy to estimate changes in the past supply of OM due to diagenetic processes. The sedimentation was finest in 3 sections: ~ 230-214 cm, ~ 185-73 cm and ~ 20-0 cm. These muddy sections are characterised, in general, by higher proportions of detrital minerals, concentrations of several chemical elements related to lithogenic sources and BFHP values. In addition, these sections are impoverished in carbonates, Ca, Sr and La when compared with the layers with the highest sand content. The clay mineral assemblage of the studied site, characterised by the dominance of illite, intermediate concentrations of kaolinite and minor amounts of smectite and chlorite, reveals the prevalence of a typical temperate humid climate in the last 3 ka BP, the estimated age for the core base. However, the quantities of illite and chlorite increase in the muddy layers. The characteristics of these muddy layers were interpreted as representing relatively cold climatic oscillations associated with the strengthening of northerly winds and the prevalence of an upwelling regime corresponding to well-known periods, such as the first cold period of the Upper Holocene (~ 2.9 ka cal BP), the Dark Ages (between ~ 2.2 -1.2 ka cal BP) and the Little Ice Age (~ 0.6 ka cal BP).

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“…However, serum cobalamin measurements have a limited ability to diagnose a deficiency state (Gultepe et al 2003). However, a good correlation exists between urinary methylmalonic acid (MMA) and serum vitamin B12 determinations.…”

Section: Vitamins B6 and B12mentioning

confidence: 99%

Consensus paper of the WFSBP Task Force on Biological Markers: Biological Markers in Depression

Mößner

Mikova

Koutsilieri

et al. 2007

The World Journal of Biological Psychiatry

227

126

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Biological markers for depression are of great interest to aid in elucidating the causes of major depression. We assess currently available biological markers to query their validity for aiding in the diagnosis of major depression. We specifically focus on neurotrophic factors, serotonergic markers, biochemical markers, immunological markers, neuroimaging, neurophysiological findings, and neuropsychological markers. We delineate the most robust biological markers of major depression. These include decreased platelet imipramine binding, decreased 5-HT1A receptor expression, increase of soluble interleukin-2 receptor and interleukin-6 in serum, decreased brain-derived neurotrophic factor in serum, hypocholesterolemia, low blood folate levels, and impaired suppression of the dexamethasone suppression test. To date, however, none of these markers are sufficiently specific to contribute to the diagnosis of major depression. Thus, with regard to new diagnostic manuals such as DSM-V and ICD-11 which are currently assessing whether biological markers may be included in diagnostic criteria, no biological markers for major depression are currently available for inclusion in the diagnostic criteria.

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Urine methylmalonic acid measurements for the assessment of cobalamin deficiency related to neuropsychiatric disorders

Cited by 24 publications

References 14 publications

Vitamin B₁₂, Folate, Homocysteine and Urinary Methylmalonic Acid Levels in Infants

Vitamin B₁₂, Folate, Homocysteine and Urinary Methylmalonic Acid Levels in Infants

Folate and homocysteine metabolisms and their roles in the biochemical basis of neuropsychiatry

Consensus paper of the WFSBP Task Force on Biological Markers: Biological Markers in Depression

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Urine methylmalonic acid measurements for the assessment of cobalamin deficiency related to neuropsychiatric disorders

Cited by 24 publications

References 14 publications

Vitamin B12, Folate, Homocysteine and Urinary Methylmalonic Acid Levels in Infants

Vitamin B12, Folate, Homocysteine and Urinary Methylmalonic Acid Levels in Infants

Folate and homocysteine metabolisms and their roles in the biochemical basis of neuropsychiatry

Consensus paper of the WFSBP Task Force on Biological Markers: Biological Markers in Depression

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Product

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Vitamin B₁₂, Folate, Homocysteine and Urinary Methylmalonic Acid Levels in Infants

Vitamin B₁₂, Folate, Homocysteine and Urinary Methylmalonic Acid Levels in Infants