Urodynamic Factors Influence the Duration of Escherichia Coli Bacteriuria in Deliberately Colonized Cases

Abstract

E. coli 83972 bacteriuria could only be established in a subset of patients with defective bladder voiding, suggesting that urodynamic defects permit a nonvirulent strain to establish in the urinary tract, but that additional host factors determine if bacteriuria will persist.

Urinary Tract Infections and the Mucosal Immune System

“…Deliberate establishment of ABU is protective. ABU is a commensal-like state and asymptomatic carriers are protected against superinfections with more virulent strains (Lindberg et al, 1978;Hagberg et al, 1984Hagberg et al, , 1989Andersson et al, 1991;Wullt et al, 1998Wullt et al, , 2000Hull et al, 2000;Darouiche et al, 2001). Asymptomatic carrier strains fail to activate disease-associated signaling pathways because of a lack of critical virulence factors and to actively suppress these pathways (Zdziarski et al, 2010).…”

“…Asymptomatic carrier strains fail to activate disease-associated signaling pathways because of a lack of critical virulence factors and to actively suppress these pathways (Zdziarski et al, 2010). The prototype ABU strain E. coli 83,972 establishes longterm bacteriuria after intravesical inoculation of human patients (Wullt et al, 1998). The genome sequence of E. coli 83,972 identified multiple deletions and point mutations resulting in smaller overall genome size, inactivated virulence gene expression, and a nonadhesive P-and type 1 fimbriae negative phenotype.…”

Indwelling catheters and neurogenic bladder: Are they really that bad?

“…Bladder interference is a process that consists of inoculating the neurogenic bladders of patients with nonpathogenic bacterial strains. This technique results in long-term asymptomatic bladder colonization [22][23][24]. In a prospective, randomized, placebo-controlled, double-blind pilot trial, Darouiche et al [25] examined the effi cacy of bacterial interference in preventing CAUTIs in 27 patients with neurogenic bladder.…”

Bacterial interference for the prevention and treatment of infections

“…The strain 83972 of Escherichia coli appears to be non-virulent for man [25]. Moreover, it is established that long-term asymptomatic bladder colonisation with E. coli 83972 is possible in patients with injuries of the spine [26,27]. Two prospective, non-randomised clinical studies [27,28] of 21 and 44 patients, respectively, with neuropathic bladder after spinal cord trauma presented evidence that artificial colonisation of the bladder with the above strain could reduce the rates of recurrent UTIs.…”