Urodynamic function during sleep-like brain states in urethane anesthetized rats

Crook, Jonathan J.; Lovick, T.A.

doi:10.1016/j.neuroscience.2015.11.027

Cited by 16 publications

(17 citation statements)

References 32 publications

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“…; Pagliardini et al . , , b ; Crook & Lovick, ; Walczak & Blasiak, ). During our recordings, we observed spontaneous brain state alternations expressed as cyclic changes in the ECoG.…”

Section: Resultsmentioning

confidence: 99%

Gamma and infra‐slow oscillations shape neuronal firing in the rat subcortical visual system

Chrobok

Palus-Chramiec

Jeczmien-Lazur

et al. 2018

The Journal of Physiology

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The physiological function of rhythmic firing in the neuronal networks of sensory systems has been linked with information coding. Also, neuronal oscillations in different frequency bands often change as a signature of brain state or sensory processing. Infra-slow oscillation (ISO) in the neuronal firing dependent on the retinal network has been described previously in the structures of the subcortical visual system. In the present study, we show for the first time that firing of ISO neurons in the lateral geniculate nucleus is also characterized by a harmonic discharge pattern (i.e. action potentials are separated by the intervals governed by fundamental frequency in the gamma range: ∼35 Hz). A similar phenomenon was recently described in the suprachiasmatic nuclei of the hypothalamus: the master biological clock. We found that both gamma and ISO rhythms were synchronized within and between ipsilateral nuclei of the subcortical visual system and were dependent on the retinal activity of the contralateral eye. These oscillatory patterns were differentially influenced by transient and prolonged light stimulation with respect to both frequency change direction and sustainability. The results of the present study show that the firing pattern of neurons in the subcortical visual system is shaped by oscillations from infra-slow and gamma frequency bands that are plausibly generated by the retinal network. Additionally, the results demonstrate that both rhythms are not a distinctive feature of image or non-image forming visual systems but, instead, they comprise two channels carrying distinctive properties of photic information.

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“…; Pagliardini et al . , , b ; Crook & Lovick, ; Walczak & Blasiak, ). During our recordings, we observed spontaneous brain state alternations expressed as cyclic changes in the ECoG.…”

Section: Resultsmentioning

confidence: 99%

Gamma and infra‐slow oscillations shape neuronal firing in the rat subcortical visual system

Chrobok

Palus-Chramiec

Jeczmien-Lazur

et al. 2018

The Journal of Physiology

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“…It has been shown that in urethane anaesthetized animals cyclic alternations of brain state and accompanying changes in physiological parameters and neuronal activity are observed (Clement et al ., ; Brown et al ., ; Whitten et al ., ; Devonshire et al ., ; Pagliardini et al ., , ,b; Sakata & Harris, ; Petzold et al ., ; Crook & Lovick, ). Urethane anaesthetized animals are widely used to study neurophysiology of dopaminergic system.…”

Section: Introductionmentioning

confidence: 99%

Midbrain dopaminergic neuron activity across alternating brain states of urethane anaesthetized rat

Walczak

Blasiak

2017

Eur J of Neuroscience

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Midbrain dopaminergic neurons are implicated in the control of motor functions and reward-driven behaviours. The function of this neuronal population is strongly connected with distinct patterns of firing - irregular or bursting, which either maintains basal levels of dopamine (DA) or leads to phasic release, respectively. Heterogeneity of dopaminergic neurons, observed on both structural and functional levels, is also reflected in different responses of DA neurons to changes in global brain states. Preparation of urethane anaesthetized animal is a broadly used model to study brain state dependent activity of neurons. Unfortunately activity of midbrain DA neurons across urethane induced cyclic, spontaneous brain state alternations is poorly described. To fulfil this gap in our knowledge we have performed simultaneous, extracellular recordings of the firing of single putative DA neurons combined with continuous brain state monitoring. We found that during slow wave activity, the firing rate of recorded putative DA neurons was significantly higher compared to firing rates during activated state, both in ventral tegmental area (VTA) and substantia nigra pars compacta (SNc). In the presence of cortical slow waves, putative dopaminergic neurons also intensified bursting activity, but the magnitude of this phenomena differed in respect to the examined region (VTA or SNc). Our results show that activity of DA neurons under urethane anaesthesia is brain-state dependent and emphasize the importance of brain state monitoring during electrophysiological experiments.

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“…The role of PAG in control of the bladder function encompasses both spinal and cortical connections. The PAG has functionally [34] and histologically [35] separate columns. These columns can be divided into two functionally separate groups having opposite autonomic functions, the ventrolateral column having parasympathetic function and the lateral and dorsolateral columns which have sympathetic functions [36,37].…”

Section: Periaqueductal Gray Matter the Headquarter Of Bladder Controlmentioning

confidence: 99%

“…Chemical stimulation of the vlPAG by D,L-homocysteic acid (DLH) in rats increases the frequency of micturition [34]. On the other hand, stereotaxic injection of the inhibitory mediator cobalt chloride into the caudal vlPAG reversibly attenuates bladder contractions and external urethral sphincter (EUS) electromyographic activity in rats [35]. Injection of other inhibitory or stimulatory agents, CoCl2 and L-glutamate, into the vlPAG lead to suppression or stimulation of voiding in rats, respectively [36].…”

Section: The Vlpag As the Major Pag Column With Connections To The Blmentioning

confidence: 99%

“…As detailed above, chemical stimulation of vlPAG increases the frequency of micturition in rats [34,36] and contracts detrusor muscle in cat [17]. On the other hand, chemical inhibition of vlPAG attenuates the detrusor and EUS contractions in rats [35,36]. Similarly, bilateral electrolytic lesion of vlPAG and lPAG in cat, attenuates detrusor contractions [40].…”

Section: Studies Featuring the Function Of The Ventrolateral Column Omentioning

confidence: 99%

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Unveiling the sensory connections between the bladder and the brain that involve the periaqueductal gray matter

Zare¹

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Urodynamic function during sleep-like brain states in urethane anesthetized rats

Cited by 16 publications

References 32 publications

Gamma and infra‐slow oscillations shape neuronal firing in the rat subcortical visual system

Gamma and infra‐slow oscillations shape neuronal firing in the rat subcortical visual system

Midbrain dopaminergic neuron activity across alternating brain states of urethane anaesthetized rat

Unveiling the sensory connections between the bladder and the brain that involve the periaqueductal gray matter

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