Urogenital tuberculosis in immunocompromised patients

Figueiredo, André Avarese de; Lucon, Antônio Marmo; Júnior, Renato Falci; Ikejiri, Diego Shiguemi; Nahas, William Carlos

doi:10.1007/s11255-008-9436-6

Cited by 26 publications

(31 citation statements)

References 18 publications

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“…4 Pulmonary symptoms are sometimes atypical and may include an unusual gastrointestinal symptomatology [11][12][13] as in our patient. In kidney recipients with prolonged fever with unusual clinical manifestations, TB should be considered, especially in endemic countries.…”

Section: Discussionmentioning

confidence: 55%

Untitled

Barbouch

Hajji²,

Helal³

et al. 2017

Exp Clin Transplant

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Tuberculosis is one of the leading infections after renal transplant, particularly in developing countries where the incidence and prevalence in the general population are high. Diagnosis requires bacteriologic and histologic confirmation. Interactions among the antitubercular drugs and the immunosuppressive agents have to be considered while prescribing, and surveillance for adverse effects is required. Although rare, case reports are available on extrapulmonary tuberculosis in allograft recipients. Here, we present a 25-year-old kidney transplant recipient who was diagnosed with lymph node tuberculosis under uncommon circumstances but who had a good outcome. This case report illustrates the difficulties in diagnosis of tuberculosis, changes in therapeutic protocols, and prognostic factors and highlights the effects of infectious complications with immunosuppressive therapy in this particular patient population.

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Section: Discussionmentioning

confidence: 55%

Untitled

Barbouch

Hajji²,

Helal³

et al. 2017

Exp Clin Transplant

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“…Chest X-ray is abnormal in 81,2% of our patients showing pulmonary infiltrates in 37,5% of cases versus 60% in literature, nodules, cavities in 6,2% of cases versus 10% in literature, miliary pattern, pleural effusion, mediastinal lymphadenopathy and/or spondilodiscitis [4,31].…”

Section: Disscussionmentioning

confidence: 60%

Mycobacterium Tuberculosis Infection Following Kidney Transplantation

Boubaker¹,

Abderrahim²,

Abdallah³

et al. 2013

AJMSM

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Tuberculosis (TB) is one of the major causes of morbidity and mortality worldwide. Post-transplant TB is a problem in successful long-term outcome of renal transplantation recipients. It is a life-threatening opportunistic infection that is frequently encountered, but the diagnosis is often delayed. With the emergence of newer potent immunosuppressive regimens and an increased incidence of TB in the general population, post-transplant TB among transplant recipients can be anticipated. Our objective was to describe the pattern and risk factors of TB infection, and the prognosis in our transplant recipients. This study was a retrospective review of the records of 491 renal transplant recipients in our hospital during the period from January 1986 to December 2009. The demographic data, transplant characteristics, clinical manifestations, diagnostic criteria, treatment protocol, and long-term outcome of this cohort of patients were analyzed. 16 patients (3.2%) developed posttransplant TB with a mean age of 32.5 ± 12.7 (range: 13-60) years and a mean post-transplant period of 36,6 months (range: 12,3 months -15.9 years). The forms of the diseases were pulmonary in 10 /16 (62.6%), disseminated in 3/16 (18.7%) and extrapulmonary in 3/16 (18.7%). All patients initially received 4-drug combination therapy. Because of drug interaction, an increase in the dose of calcineurium inhibitor and steroid was done in 2 cases and in steroids alones in 1 case. Graft dysfunction was observed in 7 cases (43,7%) with tissue-proof acute rejection in 3 cases and loss of the graft in 4 cases. Hepatotoxicity developed in 3 patients (18.7%) during treatment. Reccurence were observed in 4 cases after early stop of treatment. Two patients (12.5%) died. Extrapulmonary and disseminated tuberculosis were observed in third of our patients. More than 9 months of treatment may be necessary to prevent recurrence.

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“…33 About a third of people living with HIV worldwide are infected with tuberculosis. Patients who are HIV positive and are not infected with tuberculosis have a 10-15% risk of developing the infection.…”

Section: Tuberculosismentioning

confidence: 99%

“…Patients who are HIV positive and are not infected with tuberculosis have a 10-15% risk of developing the infection. 33 Tuberculosis has become the leading cause of death among HIV-positive patients in Africa and is the most common presenting illness among people with HIV who are taking HAART. 34 In many developing countries, concurrent HIV and tuberculosis epidemics have considerably affected already poor public health services.…”

Section: Tuberculosismentioning

confidence: 99%