Urogynecological surgical mesh implants: New trends in materials, manufacturing and therapeutic approaches

Farmer, Zara-Louise; Domínguez-Robles, Juan; Mancinelli, Caterina; Larrañeta, Eneko; Lamprou, Dimitrios A.

doi:10.1016/j.ijpharm.2020.119512

Cited by 33 publications

(28 citation statements)

References 108 publications

(177 reference statements)

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“…For example, synthetic mesh materials, such as polypropylene or polytetrafluoroethylene, derive their reinforcement benefit from the strength of their fibers at implant but never completely integrate with the patient's tissues over time [25]. Synthetic materials are often recognized as foreign by the body -as a material that needs to be removed or expunged [26]. When this occurs, an inflammatory response is initiated by the patient's immune system, setting up a chronic inflammatory state that never resolves and can result in chronic pain and fibrosis [26].…”

Section: Mechanical Reinforcement During Surgical Repairmentioning

confidence: 99%

“…Synthetic materials are often recognized as foreign by the body -as a material that needs to be removed or expunged [26]. When this occurs, an inflammatory response is initiated by the patient's immune system, setting up a chronic inflammatory state that never resolves and can result in chronic pain and fibrosis [26].…”

Section: Mechanical Reinforcement During Surgical Repairmentioning

confidence: 99%

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The Interplay of ECM-Based Graft Materials and Mechanisms of Tissue Remodeling

Hodde¹,

Hiles²

2021

Extracellular Matrix - Developments and Therapeutics

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Wound healing is a complex natural process that involves the recruitment of cells, the renewal of tissue composition, and the reinforcement of structural tissue architecture. Following ischemic injury or chronic disease, wound healing is delayed, and can often result in chronic inflammation or permanent morbidity. Tissue engineering strategies to harness the wound healing process include the use of naturally derived extracellular matrix (ECM) scaffolds with inherent bioactivity to both passively facilitate and actively direct healing toward a successful resolution. As the body heals, the properly designed ECM scaffold is gradually remodeled and integrated into the body, leaving behind organized tissue that provides long-term strength. Herein we explain the interplay of the ECM (i.e., its complex composition and bioactivity) with the cells of the body throughout the process of tissue remodeling, thus explaining how even a tissue-engineered xenograft material can direct the body to restore itself.

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Section: Mechanical Reinforcement During Surgical Repairmentioning

confidence: 99%

Section: Mechanical Reinforcement During Surgical Repairmentioning

confidence: 99%

The Interplay of ECM-Based Graft Materials and Mechanisms of Tissue Remodeling

Hodde¹,

Hiles²

2021

Extracellular Matrix - Developments and Therapeutics

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“…The feasibility of additive manufacturing (AM) and electrospinning has been extensively studied to deal with the personalized manufacturing strategies for such applications. Their exploitation could be promising to design patientspecific devices with reproducible geometrical features and increased biomimetic activity [19,20]. Some of the mentioned clinical conditions, although not life threatening, are very common into the worldwide popu-lation and can have a negative impact on patients' social life and psychology.…”

Section: General Introductionmentioning

confidence: 99%

“…Furthermore, the amount of money spent for the treatment of these pathologies is high. Specifically, in Europe the total expenditure for the management of PFDs is 10 billion euros [7,19], while around 6 million dollars and 15 million dollars are estimated to be invested in hernia and wound care devices respectively, by 2027 [21,22]. Up to now, for each clinical condition no ideal surgical mesh device exists, and despite the big number of commercially available products, they still suffer from several limitations [18].…”

Section: General Introductionmentioning

confidence: 99%

Next-generation surgical meshes for drug delivery and tissue engineering applications: materials, design and emerging manufacturing technologies

2021

Self Cite

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Surgical meshes have been employed in the management of a variety of pathological conditions including hernia, pelvic floor dysfunctions, periodontal guided bone regeneration, wound healing and more recently for breast plastic surgery after mastectomy. These common pathologies affect a wide portion of the worldwide population; therefore, an effective and enhanced treatment is crucial to ameliorate patients’ living conditions both from medical and aesthetic points of view. At present, non-absorbable synthetic polymers are the most widely used class of biomaterials for the manufacturing of mesh implants for hernia, pelvic floor dysfunctions and guided bone regeneration, with polypropylene and poly tetrafluoroethylene being the most common. Biological prostheses, such as surgical grafts, have been employed mainly for breast plastic surgery and wound healing applications. Despite the advantages of mesh implants to the treatment of these conditions, there are still many drawbacks, mainly related to the arising of a huge number of post-operative complications, among which infections are the most common. Developing a mesh that could appropriately integrate with the native tissue, promote its healing and constructive remodelling, is the key aim of ongoing research in the area of surgical mesh implants. To this end, the adoption of new biomaterials including absorbable and natural polymers, the use of drugs and advanced manufacturing technologies, such as 3D printing and electrospinning, are under investigation to address the previously mentioned challenges and improve the outcomes of future clinical practice. The aim of this work is to review the key advantages and disadvantages related to the use of surgical meshes, the main issues characterizing each clinical procedure and the future directions in terms of both novel manufacturing technologies and latest regulatory considerations. Graphic abstract

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“…Here we utilise Fused Deposition Modelling (FDM) technology for the fabrication of anti-GBM polymeric scaffold, which is one of the most investigated 3D printing technologies and a well-established manufacturing tool to fabricate polymer-based implants. Polycaprolactone (PCL) has been extensively used as the drug loading matrix for implantable devices in different applications [16][17][18]. It is an FDA-approved polymer with great biodegradability, biocompatibility, and flexibility.…”

Section: Introductionmentioning

confidence: 99%

Three-Dimensional Printing of Curcumin-Loaded Biodegradable and Flexible Scaffold for Intracranial Therapy of Glioblastoma Multiforme

Song

Fouladian

et al. 2021

Pharmaceutics

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A novel drug delivery system preventing Glioblastoma multiforme (GBM) recurrence after resection surgery is imperatively required to overcome the mechanical limitation of the current local drug delivery system and to offer personalised treatment options for GBM patients. In this study, 3D printed biodegradable flexible porous scaffolds were developed via Fused Deposition Modelling (FDM) three-dimensional (3D) printing technology for the local delivery of curcumin. The flexible porous scaffolds were 3D printed with various geometries containing 1, 3, 5, and 7% (w/w) of curcumin, respectively, using curcumin-loaded polycaprolactone (PCL) filaments. The scaffolds were characterised by a series of characterisation studies and in vitro studies were also performed including drug release study, scaffold degradation study, and cytotoxicity study. The curcumin-loaded PCL scaffolds displayed versatile spatiotemporal characteristics. The polymeric scaffolds obtained great mechanical flexibility with a low tensile modulus of less than 2 MPa, and 4 to 7-fold ultimate tensile strain, which can avoid the mechanical mismatch problem of commercially available GLIADEL wafer with a further improvement in surgical margin coverage. In vitro release profiles have demonstrated the sustained release patterns of curcumin with adjustable release amounts and durations up to 77 h. MTT study has demonstrated the great cytotoxic effect of curcumin-loaded scaffolds against the U87 human GBM cell line. Therefore, 3D printed curcumin-loaded scaffold has great promise to provide better GBM treatment options with its mechanical flexibility and customisability to match individual needs, preventing post-surgery GBM recurrence and eventually prolonging the life expectancy of GBM patients.

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Urogynecological surgical mesh implants: New trends in materials, manufacturing and therapeutic approaches

Cited by 33 publications

References 108 publications

The Interplay of ECM-Based Graft Materials and Mechanisms of Tissue Remodeling

The Interplay of ECM-Based Graft Materials and Mechanisms of Tissue Remodeling

Next-generation surgical meshes for drug delivery and tissue engineering applications: materials, design and emerging manufacturing technologies

Three-Dimensional Printing of Curcumin-Loaded Biodegradable and Flexible Scaffold for Intracranial Therapy of Glioblastoma Multiforme

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