Urokinase

Meister, Fred L.

doi:10.1001/archinte.1989.00390050157035

Cited by 9 publications

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Superior vena cava syndrome

Wudel

Nesbitt

2001

Curr. Treat. Options in Oncol.

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Lung cancer is the most common cause of superior vena cava syndrome (SVCS) and requires timely recognition and management. The syndrome is rarely an oncologic emergency in the absence of tracheal compression and airway compromise. Treatment depends on the etiology of the obstructive process. Treatment should also be individualized and should not be undertaken until a diagnosis is obtained. Most patients with SVCS secondary to lung cancer can be treated with appropriately directed chemotherapy or radiotherapy. With the refinement of endovascular stents, percutaneous stenting of the SVC is being increasingly used as primary treatment modality. Thrombotic occlusion can be treated with appropriate lytic agents. In rare circumstances, surgical decompression can be performed; bypass or replacement of the SVC results in immediate improvement in the majority of cases and can be accomplished with low morbidity.

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Superior vena cava syndrome

Wudel

Nesbitt

2001

Curr. Treat. Options in Oncol.

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Successful treatment of prolonged superior vena cava syndrome with thrombolytic therapy: A case report

Rantis

Littooy

1994

Journal of Vascular Surgery

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Superior vena cava (SVC) syndrome is most commonly due to direct compression of the SVC by a tumor. Recently, there has been an increase in the number of cases of SVC syndrome associated with chronic indwelling central venous catheters. We present a case history of a patient with prolonged symptoms of SVC syndrome that was successfully treated with catheter-directed (intraclot) infusion thrombolytic therapy with urokinase. The treatment, prevention, and incidence of SVC syndrome caused by thrombosis associated with catheters is discussed.

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