Urolithiasis in infants: evaluation of risk factors

Baştuğ, Funda; Gündüz, Zübeyde; Tülpar, Sebahat; Poyrazoğlu, Hakan; Düşünsel, Ruhan

doi:10.1007/s00345-012-0828-y

Cited by 58 publications

(53 citation statements)

References 26 publications

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“…For hypocitraturia, a spot urine citrate/ creatinine ratio of 0.42 mg/mg creatinine was used. 1 Blood samples added to test tubes containing EDTA were used to isolate the genomic DNA from peripheral blood leukocytes by means of a DNA isolation kit (Invitrogen, Carlsbad, CA). All purified DNA samples were stored at +4 C until PCR application.…”

Section: Methodsmentioning

confidence: 99%

“…The prevalence of urolithiasis is rising, both in countries in which stone disease is endemic, such as Turkey, and also in non-endemic ones, [1][2][3][4][5] either because of increasing awareness or because of the greater use of radiologic diagnostic techniques. Factors leading to urolithiasis include metabolic abnormalities, genetics, nutrition, environment, and specific medicines.…”

Section: Introductionmentioning

confidence: 99%

“…2,8 Infantile urolithiasis represents 9-23% of all pediatric cases; approximately, 60% of infants have family history of stone disease. 1,2,8 While knowledge is limited on how genetic factors mediate susceptibility to urolithiasis, one important factor is the function of the vitamin D receptor (VDR). Vitamin D plays a critical role in intestinal calcium absorption and renal calcium reabsorption, 9 and the VDR, a member of the steroid receptor family, mediates effects of the active metabolite 1,25-dihydroxyvitamin D3.…”

Section: Introductionmentioning

confidence: 99%

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The role of vitamin D receptor gene polymorphisms in Turkish infants with urolithiasis

et al. 2016

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Polymorphisms in the vitamin D receptor (VDR) gene have recently been reported to be associated with urinary calculi in pediatric and adult cases, but no studies have looked at the youngest period of life. The purpose of this study was to investigate the role of VDR gene polymorphisms in infantile urolithiasis in a Turkish population. We compared a study group of 104 infants (55 girls and 49 boys, mean age 6.94 ± 3.81 months) with a control group of 96 infants (51 girls and 45 boys, mean age 7.51 ± 3.23) to evaluate their demographics and metabolic risk factors. PCR-based restriction analysis of the polymorphisms on the VDR gene (BsmI and TaqI) showed statistically significant differences between study and control groups (p ¼ 0.001 and 0.043, respectively). In addition, the prevalence of the BsmI genotype was significantly different between the hypercalciuric and normocalciuric stone formers (p ¼ 0.007). Allelic frequencies were similar between the urolithiasis and control groups (p40.05). The B allele of BsmI and the A allele of ApaI were more prevalent in the hypercalciuric stone formers than in the normocalciuric stone formers (p ¼ 0.018 vs.0.036, respectively). These results suggest that the BsmI and TaqI VDR genotypes could be candidate genes leading to infantile urolithiasis. ARTICLE HISTORY

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The role of vitamin D receptor gene polymorphisms in Turkish infants with urolithiasis

et al. 2016

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“…Metabolic predispositions that highly contribute to urinary stone formation include disorders like idiopathic hypercalciuria, primary hyperparathyroidism, Cushing's syndrome, primary hyperoxaluria, hyperuricosuria, cystinuria and hyperchloremic metabolic acidosis [121] . Miscellaneous risk factors include obesity as high body mass index (BMI) is known to be associated with high urinary oxalate, calcium and uric acid levels [126] ; diabetes mellitus, which is known to promote formation of uric acid stones [127] ; family history of urolithiasis [118,128] ; UTI that induce formation of struvite stones; chronic consumption of drugs like triamterene, ceftriaxone, topiramate, indinavir and probenecid that eventually lead to the formation of drug stones; genetic disorders like xanthinuria, primary hyper oxaluria and idiopathic renal hyperuricosuria; structural aberration of the urinary system like that in polycystic kidney disease and medullary spongy kidney that are generally associated with urinary stasis [121] ; hot climatic conditions that cause dehydration and perspiration, ultimately leading to highly supersaturated low volume urine that again promotes stone formation [129][130][131] .…”

Section: Predisposing Factors and Preventive Dietary Modificationsmentioning

confidence: 99%

Urolithiasis: An Update on Diagnostic Modalities and Treatment Protocols

Bawari¹,

Sah²,

Tewari³

2017

Journal of Pharmaceutical Sciences

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Sweta, et al.: Diagnosis and Treatment of UrolithiasisUrolithiasis or urinary stone disease is a ubiquitous affliction that spares no geographical region or demographic. Plenty of research is being carried out in quest for mitigating this disease condition. However, any detailed information that could impart knowledge on all the major aspects of the subject in an unfractionated form is still deficient. This review is an attempt to revive the existing knowledge on urolithiasis, basically focused on its diagnosis and treatment and to provide a comprehensive data and up-to-date information on the subject matter. This article also focuses on synthetic drugs and formulations available for the treatment of urolithiasis in the global market and provides a section pertaining to risk factors and dietary preventive measures for urolithiasis.

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“…Taşlı hastaların yaklaşık %30'unda ürolojik anormallikler saptanmıştır (13,18) . Bu tablonun üriner sistemde staz yolu ile veya üriner epitelyum hasarına neden olabilen enfeksiyonlarla ilişkili olduğu düşü-nülmektedir (14) .…”

Section: Patofizyolojiunclassified