Urological Manifestations of Sarcoidosis

Rochelle, Jeffrey C. La; Coogan, Christopher L.

doi:10.1016/j.juro.2011.09.057

Cited by 22 publications

(14 citation statements)

References 44 publications

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“…Ultrasonography, computed tomography (CT) scan, and positron emission tomography imaging may all be nondiagnostic. [27] Rohatgi et al . [28] reported a renal pseudotumor simulating a renal cell carcinoma.…”

Section: Specific Organ Involvement and Clinical Manifestationsmentioning

confidence: 99%

Genitourinary sarcoidosis: An essential review for the practicing clinician

Block

Kava

2017

Indian J Urol

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Introduction:Sarcoidosis is a multisystem disease that commonly involves the lungs, but may also present with extrapulmonary manifestations. Genitourinary (GU) tract involvement has been traditionally thought to be rare, but that view may underestimate the true prevalence of the disease due to the often, silent presentation thereof.Methods:The literature pertaining to sarcoidosis from the general systemic point of view, etiology and therapy and with regard to specific organs was reviewed by identifying key words in a PubMed search. That material with special relevance to the Indian experience was emphasized.Results:There are a number of isolated case reports in the literature describing symptomatic and asymptomatic GU tract sarcoidosis. The world literature associated with the generalized syndrome was reviewed and summarized. Specific aspects of GU involvement are presented for each organ of the GU tract.Conclusions:It is critical for the practicing clinician to have a working knowledge of the clinical manifestations of this disease as it involves the GU tract, as well as to be able to distinguish it from tuberculosis and the various malignancies that affect this organ system.

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Section: Specific Organ Involvement and Clinical Manifestationsmentioning

confidence: 99%

Genitourinary sarcoidosis: An essential review for the practicing clinician

Block

Kava

2017

Indian J Urol

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“…Approximately 10% of patients with sarcoidosis have hepatic involvement, a finding that is more common in African American patients. 25 Lactate dehydrogenase can also be elevated in sarcoidosis-as in our patient-and has limited sensitivity and specificity for detecting relapse of testicular germ cell tumors (Table 3). 26 Surgical management of suspected testicular sarcoidosis with radical orchiectomy is favored by some authors in light of the above considerations and because of the significant disease Rare phenomenon, <0.2% of sarcoidosis cases Predominantly involves epididymis (75% of cases) and testis (50% of cases) and usually is unilateral Rarely affects spermatic cord, penis, or scrotum Higher incidence and severity in African Americans (10 times more frequent) Usually presents between the ages of 20-40 years burden that granulomatous inflammation can place on the functionality of the affected testicle.…”

Section: Discussionmentioning

confidence: 84%

Disseminated Sarcoidosis With Testicular Involvement

Rohani

Rana

Barot

et al. 2014

Clinical Pulmonary Medicine

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Sarcoidosis is a multisystem inflammatory disease of unknown etiology that predominantly affects the lungs and intrathoracic lymph nodes. Testicular sarcoidosis is a rare presentation of this disease. We review the case of a patient with stage 2 sarcoidosis with bilateral intrascrotal involvement along with classic pulmonary, lymphoid, and dermatological manifestations. We provide a literature review of testicular sarcoidosis and discuss the diagnostic challenges and the management of intrascrotal mass in setting of disseminated sarcoidosis. (Clin Pulm Med 2014;21:96-100) S arcoidosis is a multisystem inflammatory disease of unknown etiology that predominantly affects the pulmonary system. Although the most common presentation involves granulomatous changes of the lungs and intrathoracic lymph nodes, sarcoidosis can involve almost any organ. Testicular sarcoidosis is a rare manifestation of this disease. CASE REPORTA 46-year-old male from the West Indies with a past medical history significant for Graves disease status-post radioactive ablation and chronic normocytic anemia presented to the emergency room with a chief complaint of testicular discomfort and swelling of 1-year duration. He reported increasing bilateral testicular swelling over the past year and recently had become associated with pain and discomfort. He denied any hematuria, dysuria, urinary discharge, or urinary hesitancy. He reported progressive dyspnea on exertion and a nonproductive cough for the prior 10 months. However, he denied hemoptysis, orthopnea, or paroxysmal nocturnal dyspnea. He noted 30 to 40 pounds of unintentional weight loss over the past year and the presence of nonhealing skin lesions over his right face of >10 months duration. He denied recurrent fevers, chills, or night sweats. His social history was pertinent for heterosexual intercourse with commercial sex workers. He also had a history of inhalational cocaine use 1 year before presentation but denied any tobacco use.At initial presentation, he was afebrile. Heart rate was 115 beats per minute, blood pressure was 124/73 mm Hg, respiratory rate was 16 breaths per minute, and oxygen saturation was 96% on room air.He appeared well-nourished and was not in respiratory distress. Chest auscultation revealed bilateral inspiratory crackles and expiratory wheezes. He was tachycardic with normal heart sounds. Pertinent negative findings included the absence of jugular venous distension, organomegaly, or lower extremity edema. Genitourinary examination revealed bilateral testicular fullness with mild tenderness to palpation. Also noted were multiple, raised, irregular papules on the right side of the face, the largest measuring 1.0 cm by 1.5 cm, and bilateral polygonal scaly plaques over the pretibial areas of the lower extremities that had been present since adolescence (Fig. 1).Laboratory studies revealed normocytic anemia (hemoglobin 11.6 g/dL, MCV 90 fL) with eosinophilia (8.4%) and monocytosis (18.0%). His white blood cell count was within normal range at 4000 cells/mL. His se...

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“…Extrapulmonary involvements such as cardiovascular system, nervous system, upper respiratory tract, kidneys, spleen, thyroid, gastrointestinal tract, and musculoskeletal involvement is rare (0.4 to 5%) (3,6). Genitourinary tract involvement is much more uncommon (0.2%), and usually gives no symptom with a clinically silent presentation (7,8). Clinical course and prognosis of the disease are influenced by ethnic and genetic factors.…”

Section: Discussionmentioning

confidence: 99%

Penile Sarcoidosis: A Rare Initial Manifestation

Doruk¹,

Uçan²,

Doğan³

et al. 2016

Respir Case Rep

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Sarcoidosis is a multi-systemic disease and genitourinary involvement is rarely seen. Penile involvement is even rarer among genitourinary sarcoidosis. In this article, we present two cases of penile sarcoidosis. The first case was admitted to our urology clinic with penile itching and pain and his symptoms did not improve with non-specific antibiotic therapy. In biopsy, non-caseified granulomatous inflammation was detected. He did not have any systemic and pulmonary compliant. The second case was admitted to our urology clinic with penile nodules and nodules were excised for diagnosis. In dermis biopsy, multiple multi-nuclear giant cells and granulomas were detected. He had shortness of breath, wheezing, and sweating. He was treated with systemic prednisolone. Both cases were successfully treated with pharmacological treatments.

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Urological Manifestations of Sarcoidosis

Abstract: Urologists should be aware of the urological manifestations of sarcoidosis to avoid misdiagnoses and the over staging of urological cancers, and to identify when it is an underlying cause of nephrolithiasis or obstructive uropathy.

Cited by 22 publications

References 44 publications

Genitourinary sarcoidosis: An essential review for the practicing clinician

Genitourinary sarcoidosis: An essential review for the practicing clinician

Disseminated Sarcoidosis With Testicular Involvement

Penile Sarcoidosis: A Rare Initial Manifestation

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