Urotensin II-induced activation of extracellular signal-regulated kinase in cultured vascular smooth muscle cells: Involvement of cell adhesion-mediated integrin signaling

Tamura, Kazuhiko; Okazaki, Masahiro; Tamura, Masahito; Isozumi, Kazuhiko; Tasaki, Hiromi; Nakashima, Yasuhide

doi:10.1016/s0024-3205(02)02346-9

Cited by 46 publications

(33 citation statements)

References 35 publications

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“…8). Thus, UII stimulates P38MAPK and extracellular signal-regulated kinase 1/2 in UT-transfected cell lines (Ziltener et al, 2002), cardiac myocytes (Zou et al, 2001;Onan et al, 2004b), vascular smooth muscle cells (Watanabe et al, 2001b;Tamura et al, 2003), airway smooth muscle cells (Chen et al, 2004), endothelial cells (Matsushita et al, 2003;Guidolin et al, 2010), and endothelium-denuded rat aorta (Tasaki et al, 2004). UII also stimulates proliferation of endothelial progenitor cells through activation of p38 and p44/42 MAPK (Xu et al, 2012).…”

Section: B Signaling Mechanismsmentioning

confidence: 99%

International Union of Basic and Clinical Pharmacology. XCII. Urotensin II, Urotensin II–Related Peptide, and Their Receptor: From Structure to Function

et al. 2014

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Section: B Signaling Mechanismsmentioning

confidence: 99%

International Union of Basic and Clinical Pharmacology. XCII. Urotensin II, Urotensin II–Related Peptide, and Their Receptor: From Structure to Function

et al. 2014

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“…In addition, U-II activates nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, a major cellular source of superoxide, and plasminogen activator inhibitor-1 (PAI-1) in human pulmonary VSMCs (96), leading to the progression of atherosclerotic plaque. Activation of cell adhesion-mediated integrin signaling also plays a crucial role in U-II-induced phosphorylation involving ERK, in which FAK is not required as a signaling molecule (97). However, U-II activates FAK phosphorylation in VSMCs (95), probably leading to integrin-extracellular matrix interactions (Fig.…”

Section: U-ii and Vascular Wall Cells And Plateletsmentioning

confidence: 99%

Human Urotensin II as a Link between Hypertension and Coronary Artery Disease

et al. 2006

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“…Djordjevic et al (16) found that UII activates NADPH oxidase and plasminogen activator inhibitor-1 in VSMCs, leading to atherosclerotic plaque formation. In addition, Tamura et al (17) reported that UII stimulates the phosphorylation of p44/42MAPK, but not that of focal adhesion kinase in VSMCs. Shi et al (9) found that UII exerts proliferative effects in human umbilical vein ECs via p44/42MAPK signaling.…”

Section: Discussionmentioning

confidence: 98%

Urotensin II promotes the proliferation of endothelial progenitor cells through p38 and p44/42 MAPK activation

Wen

Jiang

2012

Mol Med Report

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Abstract. Urotensin II (UII) is a vasoactive peptide with many potent effects in the cardiorenovascular system and is also possibly involved in the pathogenesis of atherosclerosis. Endothelial progenitor cells (EPCs) are involved in angiogenesis and vascular homeostasis and may be important in the maintenance of endothelial integrity. The aim of this study was to investigate whether UII has an effect on the proliferation of bone marrow-derived EPCs and the possible signaling mechanisms involved. Bone marrow-derived EPCs were isolated from male Sprague-Dawley rats and cultured in medium containing 5% fetal bovine serum. Cells were incubated with UII for 24 h. The proliferation of EPCs was analyzed by MTT assay. Western blotting was performed to determine the phosphorylation levels of mitogen-activated protein kinases (MAPKs). The results demonstrated that UII promoted the proliferation of EPCs in a concentrationdependent manner in a certain range, and the proliferation was largely suppressed by inhibitors of GPR14 and MAPKs (p38 and p44/42). UII significantly increased the phosphorylation levels of p38MAPK and p44/42MAPK, and these effects were significantly inhibited by respective inhibitors. These findings indicate that UII promotes the proliferation of rat bone marrow-derived EPCs through a process that involves MAPK activation, and provides novel insights regarding the role of UII in the EPC-mediated repair of atherosclerotic injury.

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Urotensin II-induced activation of extracellular signal-regulated kinase in cultured vascular smooth muscle cells: Involvement of cell adhesion-mediated integrin signaling

Cited by 46 publications

References 35 publications

International Union of Basic and Clinical Pharmacology. XCII. Urotensin II, Urotensin II–Related Peptide, and Their Receptor: From Structure to Function

International Union of Basic and Clinical Pharmacology. XCII. Urotensin II, Urotensin II–Related Peptide, and Their Receptor: From Structure to Function

Human Urotensin II as a Link between Hypertension and Coronary Artery Disease

Urotensin II promotes the proliferation of endothelial progenitor cells through p38 and p44/42 MAPK activation

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