2021
DOI: 10.3748/wjg.v27.i36.6142
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Urotensin II levels in patients with inflammatory bowel disease

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Cited by 8 publications
(7 citation statements)
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“…It was previously established that U-II is one of the most potent vasoconstrictors contributing to increased peripheral resistance but also exerting effects on cardiac function [ 17 ]. These findings have been confirmed in several studies in the adult population where a clear association between U-II and hypertension has been shown [ 23 , 40 , 41 , 42 , 47 ]. A genetic study confirmed that S89N single-nucleotide polymorphism of the U-II gene plays a key role in the development of essential hypertension which possibly explains the independent association of elevated U-II levels in obese subjects with a positive family history of high blood pressure in our study [ 48 ].…”
Section: Discussionsupporting
confidence: 75%
See 1 more Smart Citation
“…It was previously established that U-II is one of the most potent vasoconstrictors contributing to increased peripheral resistance but also exerting effects on cardiac function [ 17 ]. These findings have been confirmed in several studies in the adult population where a clear association between U-II and hypertension has been shown [ 23 , 40 , 41 , 42 , 47 ]. A genetic study confirmed that S89N single-nucleotide polymorphism of the U-II gene plays a key role in the development of essential hypertension which possibly explains the independent association of elevated U-II levels in obese subjects with a positive family history of high blood pressure in our study [ 48 ].…”
Section: Discussionsupporting
confidence: 75%
“…Several studies connect U-II with the pathophysiological cascade of atherosclerosis and low-grade inflammation, which is one of the leading pathological pathways in the development of MS [ 3 , 24 , 27 , 41 ]. In a recent study in patients with inflammatory bowel disease, a positive correlation between U-II and high sensitivity C-reactive protein, a well-established biomarker of low-grade inflammation, has been observed [ 42 ]. Several studies demonstrated a possible association of U-II with indices of insulin resistance, hyperinsulinemia, and impaired glucose tolerance in hypertensive patients [ 3 , 27 , 43 ].…”
Section: Discussionmentioning
confidence: 99%
“…It has been demonstrated how the MedDiet promotes a healthy intestinal microbiota and modulates the pathogenesis and course of IBD [70][71][72][73][74]. On the other hand, clinical trials concerning specific parts of the MedDiet, like olive oil, and patients with IBD are very scarce.…”
Section: Evidence From Human Studiesmentioning
confidence: 99%
“…We read the observational study reported by Alicic et al [ 1 ], who have convincingly shown the role of elevated urotensin II (U-II) level in patients with inflammatory bowel disease (IBD). IBD comprising Crohn’s disease (CD) and ulcerative colitis (UC) is a multifactorial condition of relapsing chronic inflammation in the gastrointestinal tract with an unpredictable course[ 2 ].…”
Section: To the Editormentioning
confidence: 99%
“…Alicic et al [ 1 ] compared the blood level of U-II in IBD patients and healthy controls, and investigated the association of U-II levels with the anthropometric, clinical and biochemical parameters. The study included 50 adult patients with prediagnosed IBD (24 with UC and 26 with CD) and 50 healthy, age- and gender-matched controls.…”
Section: To the Editormentioning
confidence: 99%