Ursane-type nortriterpenes with a five-membered A-ring from Rubus innominatus

Chen, Zhenzhong; Tong, Ling; Feng, Yunchao; Wu, Jizhou; Zhao, Xiujuan; Ruan, Han‐Li; Pi, Hui‐Fang; Zhang, Peng

doi:10.1016/j.phytochem.2015.04.006

Cited by 33 publications

(24 citation statements)

References 13 publications

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“…The in vitro cytotoxicities of compounds 1 – 3 were determined by MTS (3‐(4,5‐dimethylthiazol‐2‐yl)‐5(3‐carboxymethoxyphenyl)‐2‐(4‐sulfopheny)‐2 H ‐tetrazolium) assay . Three human cancer cell lines (NCI‐H1975, HepG2, and MCF‐7) were selected for the assay.…”

Section: Methodsmentioning

confidence: 99%

“…The in vitro cytotoxicities of compounds 1 -3 were determined by MTS (3-(4,5-dimethylthiazol-2-yl)-5(3carboxymethoxyphenyl)-2-(4-sulfopheny)-2H-tetrazolium) assay. [23] [24] Three human cancer cell lines (NCI-H1975, HepG2, and MCF-7) were selected for the assay. The tested cell lines were seeded in 96-well plates, and then the plates were incubated for 24 h at 37°C in 5% CO 2 incubator.…”

Section: Cytotoxic Assaymentioning

confidence: 99%

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New Bioactive Macrocyclic Diterpenoids from Euphorbia helioscopia

Jin

Luo

Liu

et al. 2017

Chemistry & Biodiversity

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Three new macrocyclic diterpenoids, euphoscopoids A - C (1 - 3), including two new jatrophanes and a new lathyrane, were isolated from the whole plant of Euphorbia helioscopia. Their structures were elucidated by spectroscopic methods. Antifeedant and cytotoxic activities of these isolates were evaluated. All compounds showed significant antifeedant activity against a generalist plant-feeding insect, Helicoverpa armigera, with EC values ranging from 2.05 to 4.34 μg/cm . In addition, compound 2 showed moderate cytotoxicity against tumor cell lines NCI-H1975, HepG2, and MCF-2, while compounds 1 and 3 were not active at 80 μm. The results suggested not only the defensive function of macrocyclic diterpenoids in E. helioscopia against insect herbivores, but also their potential applications as new natural insect antifeedants.

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Section: Methodsmentioning

confidence: 99%

Section: Cytotoxic Assaymentioning

confidence: 99%

New Bioactive Macrocyclic Diterpenoids from Euphorbia helioscopia

Jin

Luo

Liu

et al. 2017

Chemistry & Biodiversity

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“…Five triterpenes (17-21) had been isolated from Rubus allegheniensis (Ono et al 2014), Eriobotrya japonica (Taniguchi et al 2002), Rubus sieboldii (Murakami et al 2002), Rubus innominatus (Chen et al 2015), A. pilosa (Ahn et al 2012, and Exochorda racemosa . The rest triterpene (21) was initially reported from Agrimonia which had been isolated from R. soulieana (Rosoideae) .…”

Section: Chemotaxonomic Significancementioning

confidence: 99%

Chemical constituents from Agrimonia pilosa Ledeb. and their chemotaxonomic significance

Liu

Hou

Chen

et al. 2016

Natural Product Research

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Phytochemical investigation of the ethanol extract from the whole plant of Agrimonia pilosa led to the isolation of 31 compounds, including 16 flavonoids (1-16), 5 triterpenes (17-21), 1 isocoumarin (22), 5 phenolic acids (23-27), 1 ceramide (28), 2 agrimols (29-30) and 1 fatty acid (31). Their structures were determined by various spectroscopic analyses. Compounds 5, 7 and 20 were firstly isolated from the genus Agrimonia, and compounds 6, 10-11, 15, 26, 28 and 31 were isolated from the family Rosaceae for the first time. Moreover, the chemotaxonomic significance of these compounds was summarised.

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“…165 The highly oxygenated lupane derivatives 545 and 546 are constituents of cashew nuts (Anacardium occidentale). 166 175 Termichebuloside A 589, a dimeric oleanane diglucosyl ester from Terminalia chebula, is the 4,4 0 -diepimer of the known ivorenoside A. 187 The rhamnoside 590, from Gueldenstaedtia verna has a new genin.…”

Section: The Lupane Groupmentioning

confidence: 99%

“…Nerium indicum, 172 the 4-hydroxy-3-methoxybenzoyl ester 558 from Paullinia pinnata,173 the cafeoyl ester 559 from Celastrus stylosus174 and the 2-benzoyl ester of alphitolic acid from Rubus innominatus175 Hancokinoside, from Allophylus africanus, is the 2-O-b-D-glucopyranoside of the known hancokinol although the diagram in the reference is inaccurate 176. Other lupane saponins with known genins include royleanumioside from Teucrium royleanum177 and a saponin from Cyperus rotundus 178.…”

mentioning

confidence: 99%