Ursolic Acid Inhibits Breast Cancer Metastasis by Suppressing Glycolytic Metabolism via Activating SP1/Caveolin-1 Signaling

Wang, Shengqi; Xu, Chang; Zhang, Juping; Li, Jing; Wang, Neng; Yang, Bowen; Pan, Bo; Zheng, Yifeng; Wang, Xuan; Ou, Hesheng; Wang, Zhiyu

doi:10.3389/fonc.2021.745584

Cited by 23 publications

(23 citation statements)

References 58 publications

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“…Treatment with ursolic acid increased SP1 expression and promoted SP1 binding to the Caveolin-1 ( CAV1 ) promoter to increase CAV1 transcription. Activation of CAV1 by SP1 downregulates glycolytic metabolism and damages mitochondrial function in breast cancer cells [ 95 ].…”

Section: Breast Cancermentioning

confidence: 99%

SP and KLF Transcription Factors in Cancer Metabolism

Orzechowska-Licari

LaComb

Mojumdar

et al. 2022

IJMS

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Tumor development and progression depend on reprogramming of signaling pathways that regulate cell metabolism. Alterations to various metabolic pathways such as glycolysis, oxidative phosphorylation, lipid metabolism, and hexosamine biosynthesis pathway are crucial to sustain increased redox, bioenergetic, and biosynthesis demands of a tumor cell. Transcription factors (oncogenes and tumor suppressors) play crucial roles in modulating these alterations, and their functions are tethered to major metabolic pathways under homeostatic conditions and disease initiation and advancement. Specificity proteins (SPs) and Krüppel-like factors (KLFs) are closely related transcription factors characterized by three highly conserved zinc fingers domains that interact with DNA. Studies have demonstrated that SP and KLF transcription factors are expressed in various tissues and regulate diverse processes such as proliferation, differentiation, apoptosis, inflammation, and tumorigenesis. This review highlights the role of SP and KLF transcription factors in the metabolism of various cancers and their impact on tumorigenesis. A better understanding of the role and underlying mechanisms governing the metabolic changes during tumorigenesis could provide new therapeutic opportunities for cancer treatment.

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Section: Breast Cancermentioning

confidence: 99%

SP and KLF Transcription Factors in Cancer Metabolism

Orzechowska-Licari

LaComb

Mojumdar

et al. 2022

IJMS

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“…It has also been shown that ursolic acid suppressed proliferation and induced apoptosis in breast cancer cells, but not in non-malignant cells. Ursolic acid also repressed metastasis in both zebrafish and mouse models via the suppression of glycolysis through the activation of SP1/caveolin-1 signaling [ 159 ]. Another research group has demonstrated that ursolic acid inhibited energy metabolism.…”

Section: Plants From Different Continents Used In Ethnomedicine For T...mentioning

confidence: 99%

How Should the Worldwide Knowledge of Traditional Cancer Healing Be Integrated with Herbs and Mushrooms into Modern Molecular Pharmacology?

et al. 2022

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Traditional herbal medicine (THM) is a “core” from which modern medicine has evolved over time. Besides this, one third of people worldwide have no access to modern medicine and rely only on traditional medicine. To date, drugs of plant origin, or their derivates (paclitaxel, vinblastine, vincristine, vinorelbine, etoposide, camptothecin, topotecan, irinotecan, and omacetaxine), are very important in the therapy of malignancies and they are included in most chemotherapeutic regimes. To date, 391,000 plant and 14,000 mushroom species exist. Their medical and biochemical capabilities have not been studied in detail. In this review, we systematized the information about plants and mushrooms, as well as their active compounds with antitumor properties. Plants and mushrooms are divided based on the regions where they are used in ethnomedicine to treat malignancies. The majority of their active compounds with antineoplastic properties and mechanisms of action are described. Furthermore, on the basis of the available information, we divided them into two priority groups for research and for their potential of use in antitumor therapy. As there are many prerequisites and some examples how THM helps and strengthens modern medicine, finally, we discuss the positive points of THM and the management required to transform and integrate THM into the modern medicine practice.

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“…Ursolic acid is a pentacyclic triterpenoid found in apple peels (Malus domestica) [100,101]. Ursolic acid protects against breast cancer by activating SFRP4 (Wnt agonist), inhibiting miRNA-499A-5p in MCF7, MDA-MB-231, and CSC cells [102], and also activates SP1/Caveoli-1 signaling, thereby inhibiting breast cancer metastasis [103]. Ursolic acid also protects against intestinal cancer progression, where it dose-dependently attenuates the number and growth of cells while down-regulating FN1, CDH2, CTNNB1, and TWSIT gene expression.…”

Section: Ursolic Acidmentioning

confidence: 99%

“…Ursolic acid Apple peels ↑ sFRP4, sp1, Caveolin-1, Bax, p21, p53, Cyclin B1, Caspase-3, Caspase-8, Caspase-9, fibronectin-1, E-Cad, and LC3-II Gliolastoma [104], breast [100,101], intestinal [102], lung [103], colorectal [105], esophageal [106], and pancreatic [107] [111], breast [112,113], prostate [115], ovarian [114], colorectal [116,117], lung [118], gastric [56], and endometrial [119] cancer ↓ MMP-2, FAK, CDK1, PSA, TMPRSS2, TMEPA1, PI3K, Akt, Bcl-2, TS, RhoA, Rac1, JAK/STAT3, MAPK, and NFκB Quercetin Apple, chili pepper, blueberry, cherry, cranberry, black tea, and red wine ↑ p53 Liver [120,121], prostate [122,123], colon [123], leukemia [123], lymphoma [123], breast [123,124], pancreatic [125], lung [126],…”

mentioning

confidence: 99%

The Anti-Cancer Effects of Red-Pigmented Foods: Biomarker Modulation and Mechanisms Underlying Cancer Progression

2022

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Cancer is one the most malignant diseases that is a leading cause of death worldwide. Vegetables and fruits contain beneficial nutrients such as vitamins, minerals, folates, dietary fibers, and various natural bioactive compounds. These can prevent the pathological processes of many cancers and reduce cancer related mortality. Specifically, the anti-cancer effect of vegetables and fruits is largely attributable to the natural bioactive compounds present within them. A lot of bioactive compounds have very specific colors with pigments and the action of them in the human body varies by their color. Red-pigmented foods, such as apples, oranges, tomatoes, cherries, grapes, berries, and red wine, have been widely reported to elicit beneficial effects and have been investigated for their anti-tumor, anti-inflammatory, and antioxidative properties, as well as anti-cancer effect. Most of the anti-cancer effects of bioactive compounds in red-pigmented foods arise from the suppression of cancer cell invasion and metastasis, as well as the induction of apoptosis and cell cycle arrest. In this review, we assessed publications from the last 10 years and identified 10 bioactive compounds commonly studied in red-pigmented foods: lycopene, anthocyanin, β-carotene, pectin, betaine, rutin, ursolic acid, kaempferol, quercetin, and myricetin. We focused on the mechanisms and targets underlying the anti-cancer effect of the compounds and provided rationale for further investigation of the compounds to develop more potent anti-cancer treatment methods.

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Ursolic Acid Inhibits Breast Cancer Metastasis by Suppressing Glycolytic Metabolism via Activating SP1/Caveolin-1 Signaling

Cited by 23 publications

References 58 publications

SP and KLF Transcription Factors in Cancer Metabolism

SP and KLF Transcription Factors in Cancer Metabolism

How Should the Worldwide Knowledge of Traditional Cancer Healing Be Integrated with Herbs and Mushrooms into Modern Molecular Pharmacology?

The Anti-Cancer Effects of Red-Pigmented Foods: Biomarker Modulation and Mechanisms Underlying Cancer Progression

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