Urtica dioica Extract Inhibits Proliferation and Induces Apoptosis and Related Gene Expression of Breast Cancer Cells In Vitro and In Vivo

Mohammadi, Ali; Mansoori, Behzad; Baradaran, Pooneh Chokhachi; Khaze, Vahid; Aghapour, Mahyar; Farhadi, Mehrdad; Baradaran, Behzad

doi:10.1016/j.clbc.2017.04.008

Cited by 21 publications

(16 citation statements)

References 17 publications

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“…UD extract inhibited the proliferation of breast cancer cells in a BALB/c mouse model, leading to a significant decrease in the tumor mass in a dose-dependent pattern compared to the control group. In addition, the extract suppressed the growth of the tumor cells as measured using Ki-67 tests [41]. Moreover, UD dried leaf aqueous extract exerted a dose-dependent antioxidant and apoptotic effects on breast cancer cell line MCF-7 after 72 h of treatment, with an IC 50 of 2mg/mL [17].…”

Section: Discussionmentioning

confidence: 97%

Nettle Tea Inhibits Growth of Acute Myeloid Leukemia Cells In Vitro by Promoting Apoptosis

et al. 2020

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Urtica dioica (UD), commonly known as “stinging nettle”, is a herbaceous flowering plant that is a widely used agent in traditional medicine worldwide. Several formulations of UD leaf extract have been reported to exhibit anti-inflammatory and antioxidant properties, with anticancer potential. The current study investigated the possible anticancer properties of nettle tea, prepared from Urtica dioica leaves, on acute myeloid leukemia (AML) cell lines, and deciphered the underlying molecular mechanisms. Treatment of AML cell lines (U-937 and KG-1) with UD aqueous leaf extract resulted in a dose- and time-dependent inhibition of proliferation, an increase in apoptotic hallmarks such as phosphatidylserine flipping to the outer membrane leaflet, and DNA fragmentation as revealed by cell-death ELISA and cell-cycle analysis assays. Apoptosis induction in U937 cells involves alterations in the expression of Bax and Bcl-2 upon exposure to nettle tea. Furthermore, the chemical composition of UD aqueous extract indicated the presence of multiple chemical agents, such as flavonoids and phenolics, mainly patuletin, m/p-hydroxybenzoic acid, and caffeic acid, among others, to which the pro-apoptotic and anti-tumor effects may be attributed.

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Section: Discussionmentioning

confidence: 97%

Nettle Tea Inhibits Growth of Acute Myeloid Leukemia Cells In Vitro by Promoting Apoptosis

et al. 2020

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“…According to WHO, approximately four‐fifths of the world's population, mainly in the Middle Eastern and low‐income countries, meet their daily primary health care demands via herbal and natural therapies as well as traditional medicines . Nowadays, in developing countries such as Iran, traditional medicine has been utilized as the main source of complementary or alternative medicine in new health care and medicinal products.…”

Section: Discussionmentioning

confidence: 99%

“…Nowadays, in developing countries such as Iran, traditional medicine has been utilized as the main source of complementary or alternative medicine in new health care and medicinal products. The use of herbal plants in pharmaceutical research and the drug's development are of uttermost importance . Although the anti‐inflammatory, antioxidant, anti‐ Helicobacter pylori and antigiardial activities of S ebulus extract have previously been reported, the antileishmanial activity has not been described yet.…”

Section: Discussionmentioning

confidence: 99%

Sambucus ebulus extract stimulates cellular responses in cutaneous leishmaniasis

Heidari‐Kharaji

Omrani

Badirzadeh

et al. 2018

Parasite Immunology

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Summary This is the first study aiming to determine the therapeutic effects of the Sambucus ebulus aquatic extract as an antileishmanial herbal drug and evaluate the immune responses in Leishmania major major infected BALB/c mice. The antileishmanial activity of S ebulus aquatic extract was evaluated using MTT test as well as parasite rescue and transformation assay. Footpad swelling and parasite load of infected mice were measured by several techniques. The immune responses were evaluated by measuring the levels of IFN‐γ, IL‐4, nitric oxide and arginase. The results indicated that S. ebulus can significantly decrease L. major promastigotes and amastigotes viability, but it was not toxic to macrophages. The lesion size, parasite burden and the level of ARG decreased in the treated infected mice, while the IFN‐γ‐to‐IL‐4 ratio and the level of NO increased significantly. Altogether, the S. ebulus extract is an effective compound for killing Leishmania parasite without excessive toxicity to the host cells and can cure the CL by switching the host immune responses towards Th1 response. Thus, it may be a perfect therapeutic option for CL treatment.

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“…Mohammadi et al (2017) [132] prepared an in vivo -induced model of breast cancer, mice Balb/c with allograft tumors caused by injecting subcutaneously 4T1 murine breast tumor cells, and then administered U. dioica leaves dichloromethane extract (10 or 20 mg/kg body weight) by intraperitoneal injection for 28 days. Interestingly, U. dioica extract significantly reduced the tumor masses in the treated mice and significantly diminished the size and weight of the tumors removed from the treated mice.…”

Section: Anticancer Activities Of Urtica Dioicamentioning

confidence: 99%

Therapeutic Perspectives of Molecules from Urtica dioica Extracts for Cancer Treatment

et al. 2019

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A large range of chronic and degenerative diseases can be prevented through the use of food products and food bioactives. This study reports the health benefits and biological activities of the Urtica dioica (U. dioica) edible plant, with particular focus on its cancer chemopreventive potential. Numerous studies have attempted to investigate the most efficient anti-cancer therapy with few side effects and high toxicity on cancer cells to overcome the chemoresistance of cancer cells and the adverse effects of current therapies. In this regard, natural products from edible plants have been assessed as sources of anti-cancer agents. In this article, we review current knowledge from studies that have examined the cytotoxic, anti-tumor and anti-metastatic effects of U. dioica plant on several human cancers. Special attention has been dedicated to the treatment of breast cancer, the most prevalent cancer among women and one of the main causes of death worldwide. The anti-proliferative and apoptotic effects of U. dioica have been demonstrated on different human cancers, investigating the properties of U. dioica at cellular and molecular levels. The potent cytotoxicity and anti-cancer activity of the U. dioica extracts are due to its bioactive natural products content, including polyphenols which reportedly possess anti-oxidant, anti-mutagenic and anti-proliferative properties. The efficacy of this edible plant to prevent or mitigate human cancers has been demonstrated in laboratory conditions as well as in experimental animal models, paving the way to the development of nutraceuticals for new anti-cancer therapies.

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Urtica dioica Extract Inhibits Proliferation and Induces Apoptosis and Related Gene Expression of Breast Cancer Cells In Vitro and In Vivo

Cited by 21 publications

References 17 publications

Nettle Tea Inhibits Growth of Acute Myeloid Leukemia Cells In Vitro by Promoting Apoptosis

Nettle Tea Inhibits Growth of Acute Myeloid Leukemia Cells In Vitro by Promoting Apoptosis

Sambucus ebulus extract stimulates cellular responses in cutaneous leishmaniasis

Therapeutic Perspectives of Molecules from Urtica dioica Extracts for Cancer Treatment

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