Urticaria crónica: estudio etiológico prospectivo e importancia del síndrome autoinmune

Giménez‐Arnau, Ana; Ferrer, Marta; Peter, H.; Maurer, Marcus; Pujol, Ramón M.

doi:10.1016/s0001-7310(04)76883-0

Cited by 11 publications

(11 citation statements)

References 13 publications

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“…Our study was focused in the genetic signature of a particular subset of patients suffering from severely active CSU. In our series, the mean UAS7 was 33.6 (range 16‐42) …”

Section: Discussionmentioning

confidence: 48%

Transcriptome analysis of severely active chronic spontaneous urticaria shows an overall immunological skin involvement

Giménez‐Arnau

Curto‐Barredo

Nonell

et al. 2017

Allergy

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“…Our study was focused in the genetic signature of a particular subset of patients suffering from severely active CSU. In our series, the mean UAS7 was 33.6 (range 16‐42) …”

Section: Discussionmentioning

confidence: 48%

Transcriptome analysis of severely active chronic spontaneous urticaria shows an overall immunological skin involvement

Giménez‐Arnau

Curto‐Barredo

Nonell

et al. 2017

Allergy

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“…Twenty‐two percent of the patients who were tested for thyroid function had clinical or subclinical thyroid disease. This association between autoimmune thyroid disease and CSU is well known and is one of the clinical associations that contributed to build the autoimmune hypothesis .…”

Section: Resultsmentioning

confidence: 87%

Basophil Activation Test identifies the patients with Chronic Spontaneous Urticaria suffering the most active disease

Curto‐Barredo

Yélamos²,

Gimeno³

et al. 2016

Immunity Inflam & Disease

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IntroductionThe basophil activation test showing CD63 up regulation could be a specific and sensitive in vitro complementary text to the in vivo autologous serum skin test for the activity assessment of the patients suffering autoimmune chronic spontaneous urticaria. The aim of this study is to define the basophil activation test as a useful tool in clinical practice in order to identify those patients with more active disease.MethodsWe screened 139 patients (96 women) diagnosed of chronic spontaneous urticaria using simultaneously autologous serum skin test and basophil activation test and their relationship with disease activity.ResultsPositive autologous serum skin test was found in 56.8%; from them, 31.6% were basophil activation test positive. Negative autologous serum skin test result was found in the 43.2% of the sample that showed negative CD63 expression results in all cases, except one. Patients with positive autologous serum skin test and positive CD63 by basophil activation test showed significant higher Urticaria Activity Score of 7 days (P = 0.004) and of 3 weeks (P = 0.001) than patients with positive autologous serum skin test and negative CD63 (mean ± standard deviation [SD] 26.57 ± 10.56 versus 18.40 ± 12.05 for the Urticaria Activity Score of 7 days and 56.47 ± 23.78 versus 39.88 ± 25.44 for the Urticaria Activity Score of 3 weeks).ConclusionsThe CD63 expression on basophils appears as a reliable in vitro marker, useful in clinical practice in combination with autologous serum skin test to define chronic spontaneous urticaria patients with the highest urticaria activity that impairs a normal life.

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“…The majority of studies show clearly that women suffer from urticaria nearly twice as often as men do (5, 6, 8–13, 16, 17, 20–24). This is not only true for chronic spontaneous urticaria, but also for urticaria in general.…”

Section: Prevalence Of Chronic Spontaneous Urticariamentioning

confidence: 99%

“…The peak age of chronic spontaneous urticaria patients is between 20 and 40 years in most studies (11, 12, 14, 16, 19, 20, 24). This means that patients are primarily affected during important years of their working age.…”

Section: Prevalence Of Chronic Spontaneous Urticariamentioning

confidence: 99%

“…It has been demonstrated that around one‐third of patients with chronic spontaneous urticaria shows a positive response against their own serum in the ASST (12, 18, 22–24, 28) and that in some of these patients, it is possible to identify autoantibodies against the high‐affinity IgE‐receptor (FcɛR1) or IgE. These functional autoantibodies can be detected by the basophil histamine release assay.…”

Section: Prognostic Factors Of Chronic Spontaneous Urticariamentioning

confidence: 99%

See 1 more Smart Citation

Unmet clinical needs in chronic spontaneous urticaria. A GA2LEN task force report1

Maurer

Weller

Bindslev‐Jensen

et al. 2010

Allergy

687

740

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Chronic spontaneous urticaria, formerly also known as chronic idiopathic urticaria and chronic urticaria (CU), is more common than previously thought. At any time, 0.5-1% of the population suffers from the disease (point prevalence). Although all age groups can be affected, the peak incidence is seen between 20 and 40 years of age. The duration of the disease is generally 1-5 years but is likely to be longer in more severe cases, cases with concurrent angioedema, in combination with physical urticaria or with a positive autologous serum skin test (autoreactivity). Chronic spontaneous urticaria has major detrimental effects on quality of life, with sleep deprivation and psychiatric comorbidity being frequent. It also has a large impact on society in terms of direct and indirect health care costs as well as reduced performance at work and in private life. In the majority of patients, an underlying cause cannot be identified making a causal and/or curative treatment difficult. Nonsedating H 1 -antihistamines are the mainstay of symptomatic therapy, but treatment with licensed doses relieves symptoms effectively in <50% of patients. Although guideline-recommended updosing up to fourfold increases symptom control in many patients, a substantial number of patients have only little benefit from H 1 -antihistamines. Consequently, there is a great need for new therapeutic strategies.

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Urticaria crónica: estudio etiológico prospectivo e importancia del síndrome autoinmune

Cited by 11 publications

References 13 publications

Transcriptome analysis of severely active chronic spontaneous urticaria shows an overall immunological skin involvement

Transcriptome analysis of severely active chronic spontaneous urticaria shows an overall immunological skin involvement

Basophil Activation Test identifies the patients with Chronic Spontaneous Urticaria suffering the most active disease

Unmet clinical needs in chronic spontaneous urticaria. A GA2LEN task force report1

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