Usage of natural chitosan membrane obtained from insect corneal lenses as a drug carrier and its potential for point of care tests

Torun, Ilker; Ramanauskaitė, Aurelija; Bilican, Behlül Koç; Mulerčikas, Povilas; Çam, Dilek; Önses, M. Serdar; Kazlauskaitė, Sonata; Baublys, Vykintas; Aydın, Ömer; Zang, Lian-Sheng; Kaya, Murat

doi:10.1016/j.msec.2020.110897

Cited by 20 publications

(19 citation statements)

References 39 publications

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“…Blends of other natural polysaccharides, such as chitosan with Bletilla Strata polysaccharides, show antibacterial, antioxidant activity, and improvement of cell proliferation (experiment performed on mouse fibroblast: L929 cell line [226].…”

Section: Chitosan Membranesmentioning

confidence: 99%

Chitosan as an Underrated Polymer in Modern Tissue Engineering

Kołodziejska¹,

Jankowska²,

Klak³

et al. 2021

Nanomaterials

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Chitosan is one of the most well-known and characterized materials applied in tissue engineering. Due to its unique chemical, biological and physical properties chitosan is frequently used as the main component in a variety of biomaterials such as membranes, scaffolds, drug carriers, hydrogels and, lastly, as a component of bio-ink dedicated to medical applications. Chitosan’s chemical structure and presence of active chemical groups allow for modification for tailoring material to meet specific requirements according to intended use such as adequate endurance, mechanical properties or biodegradability time. Chitosan can be blended with natural (gelatin, hyaluronic acid, collagen, silk, alginate, agarose, starch, cellulose, carbon nanotubes, natural rubber latex, κ-carrageenan) and synthetic (PVA, PEO, PVP, PNIPPAm PCL, PLA, PLLA, PAA) polymers as well as with other promising materials such as aloe vera, silica, MMt and many more. Chitosan has several derivates: carboxymethylated, acylated, quaternary ammonium, thiolated, and grafted chitosan. Its versatility and comprehensiveness are confirming by further chitosan utilization as a leading constituent of innovative bio-inks applied for tissue engineering. This review examines all the aspects described above, as well as is focusing on a novel application of chitosan and its modifications, including the 3D bioprinting technique which shows great potential among other techniques applied to biomaterials fabrication.

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Section: Chitosan Membranesmentioning

confidence: 99%

Chitosan as an Underrated Polymer in Modern Tissue Engineering

Kołodziejska¹,

Jankowska²,

Klak³

et al. 2021

Nanomaterials

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“…Chitin and chitosan are known as secondary abundant polymers obtained from the external skeleton of crustaceans such as crab and shrimp [26]. Apart from this, chitin is also found in and produced from the exoskeleton of insects or the cell walls of fungi and yeast [6,27,28]; however, this contribution is much less than that from the marine resources. In recent years, chitin and chitosan have gained attention instead of raw materials of petroleum origin owing to the inevitable depletion of fossil fuels and the prevention of climate change [29].…”

Section: Physicochemical Properties and Gelling Characteristicsmentioning

confidence: 99%

“…Chitin and chitosan obtained from crustaceans possess sufficient environmental adaptability as well as an attractive potential to build various types of functional media, e.g., membranes [6][7][8][9][10], micro/nanoparticles [11,12], and nanofibers [13][14][15][16]. Many studies have devoted to develop the novel media adapting separation processes using chitosan.…”

Section: Introductionmentioning

confidence: 99%

Innovative Separation Technology Utilizing Marine Bioresources: Multifaceted Development of a Chitosan-Based System Leading to Environmentally-Friendly Processes

Kashima¹,

Takahashi²,

Nakayama³

et al. 2021

Chitin and Chitosan - Physicochemical Properties and Industrial Applications [Working Title]

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Chitosan, known as a most typical marine biological polymer, has a fruitful capability of biocompatible gel formation. Attempts of chitosan have been made to develop it from the multifaceted viewpoint of separation technology. The physicochemical properties of chitosan containing a lot of hydroxyl groups and reactive amino groups help to build the characteristic polymer networks. The deacetylation degree of chitosan is found as the most influential factor to regulate properties of chitosan hydrogels. The antibacterial activity of the chitosan membrane is one of its notable abilities because of its practical application. The chitosan, its derivatives, and the complex formation with other substances has been used for applications in filtration and membrane separation processes. Adsorption processes based on chitosan have been also developed widely. Moreover, complex of chitosan gel helps to immobilize adsorbent particles. The chitosan membrane immobilizing Prussian-Blue for cesium ion removal from the aqueous phase is one of the leading cases. To elaborate the adsorption behavior on the chitosan immobilizing adsorbent, the isothermal equilibrium and mass transfer characteristics can be discussed. The adsorption process using chitosan-based membranes in combination with filtration in a flow process is advantageous compared with the batch process. More advanced studies of chitosan aerogel and chitosan nanofibers have been proceeded recently, especially for adapting to water purification and air filtration.

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“…Hence, the interaction between the body and the drug‐carrier is of great importance. Toxicity can be divided into four categories: acute, subacute, subchronic, and chronic 102‐106 …”

Section: Toxicity Definitionsmentioning

confidence: 99%

Targeted delivery, drug release strategies, and toxicity study of polymeric drug nanocarriers

Abasian

Shakibi

Maniati

et al. 2020

Polymers for Advanced Techs

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Science has been trying to deal with complex diseases, like cancer, for a long time. Indeed, the side effects of the conventional treatment methods are tremendous, in some cases irreversible. This kind of problems demands a solution. Therefore, novel drug delivery systems are devised to mitigate the negative impacts of conventional ones. Polymeric nanocarrier systems are of great importance in this newly opened field. Polymers having been vastly investigated are common in some properties, such as their being biocompatibility and biodegradability. Generally speaking, a set of properties is required to achieve optimum delivery of drugs to target organs with minimum side effects. To do so, some measures should be taken. First of all, the strategy for release should be determined, categorized into two main branches, active and passive. Next, the drug release method should be engineered. Generally, there are two main categories for drug release, exogenous and endogenous. In this review, some of the chief subcategories of any aforementioned items are discussed. In the end, we catch up on already engineered nanocarriers' administration to the human body, possible toxic effects, if any, and the routes for affecting as a toxin.

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Usage of natural chitosan membrane obtained from insect corneal lenses as a drug carrier and its potential for point of care tests

Cited by 20 publications

References 39 publications

Chitosan as an Underrated Polymer in Modern Tissue Engineering

Chitosan as an Underrated Polymer in Modern Tissue Engineering

Innovative Separation Technology Utilizing Marine Bioresources: Multifaceted Development of a Chitosan-Based System Leading to Environmentally-Friendly Processes

Targeted delivery, drug release strategies, and toxicity study of polymeric drug nanocarriers

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