Use of a Fundamental Approach to Spray-Drying Formulation Design to Facilitate the Development of Multi-Component Dry Powder Aerosols for Respiratory Drug Delivery

Abstract

Theoretical models were applied to successfully achieve complex formulations with design challenges a priori. No further iterations to the design process were required.

Experimental investigations of particle formation from propellant and solvent droplets using a monodisperse spray dryer

“…The formation of solid particles from evaporating solution droplets is a phenomenon of some interest in the field of aerosol science, with particular importance in pharmaceutical spray drying (Paudel et al 2013;Singh and Van den Mooter 2016) and inhaled drug delivery (Sheth et al 2017;Zhu et al 2015). The initial size and composition of the droplet and the conditions under which it evaporates determine the kinetics of the transition from droplet to residual particle, with consequences for the morphology and degree of molecular order of the dried particle (Hoe et al 2014). Developing an understanding of these relationships is within the purview of particle engineering, a discipline that has proven useful in applications where precise control over particle properties is required.…”

Control of the radial distribution of chemical components in spray-dried crystalline microparticles

“…The role of respiratory drug delivery in effective interventions for lung diseases continues to attract much interest (Beck-Broichsitter et al 2014;Hoe et al 2014;Lechuga-Ballesteros and Miller 2015;Zhou et al 2015). The diameter of drug-containing particles delivered to the lung is commonly in the micrometer range (Longest et al 2012;Islan et al 2015).…”

“…The particle formation process for single-component solution droplets has been investigated quite thoroughly (Shekunov and York 2000;Hakuta et al 2003;Shoyele and Cawthorne 2006;Vehring et al 2007;Zhang et al 2011;Boraey et al 2013;Vladisavljevi c et al 2014;Baldelli et al 2015). In contrast, few researchers have investigated particle formation from evaporating droplets with more than one chemical component (Zhang and Stangle 1994;Zhu and Hayward 2012;Hoe et al 2014), which is the more relevant case for most formulations in respiratory drug delivery. The characteristics of multicomponent particles are strongly dependent on the composition of their surface or shell (De Villiers et al 2002).…”

Polymer–Lipid Microparticles for Pulmonary Delivery

“…Drug release was carried out over 24 h in a shaking thermostatic (37 ºC) water bath. At predetermined time intervals (0,5,10,20,30, 60, 90, 120, 180, 240, 300, 360, 720 and 1440 min), aliquots of 1 mL of the release medium were withdrawn, and instantly replaced with fresh SLF. The concentration of BD in each aliquot was determined using an HPLC system consisting of an LC-10 AD VP pump, a SIL-20A HT autosampler and a UV-Vis SPD-10A VP detector that had been interfaced to Class VP Chromatography data system v.4.Shimadzu):41 stationary phase, Ascentis C8 column (150 mm, 4.6 mm, 5µm); mobile phase, acetonitrile potassium dihydrogen phosphate (60:40 v/v; 0.025M; pH 3.2, adjusted with phosphoric acid).…”