Use of a Modified Test System to Determine Early Pregnancy Factor (EPF) Levels in Patients with Normal First Trimester Pregnancy and after Therapeutic Abortion

Tinneberg, Hans‐Rudolf; Staves, R.P.; Hanf, Volker; Scholz, W.; Semm, K; Mettler, L.

doi:10.1111/j.1749-6632.1985.tb37564.x

Annals of the New York Academy of Sciences

1985

DOI: 10.1111/j.1749-6632.1985.tb37564.x

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Use of a Modified Test System to Determine Early Pregnancy Factor (EPF) Levels in Patients with Normal First Trimester Pregnancy and after Therapeutic Abortion

Hans‐Rudolf Tinneberg¹,

R.P. Staves²,

Volker Hanf³

et al.

Abstract: Human pregnancy can be recognized as early as 48 hours after conception using the rosette inhibition test (RIT) to detect early pregnancy factor (EPF). A modification of the test as originally described by Morton et al. is demonstrated using a monoclonal pan T-cell antibody. Studies were performed to investigate the relationship between EPF levels during normal first trimester intact pregnancies and therapeutic abortions. The change in EPF levels is compared with those of hormones after interrupted pregnancy.

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1989

1992

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Cited by 4 publications

(1 citation statement)

References 6 publications

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“…Most conceptions are lost during the preclinical stage of gestation and the women are unaware they have occurred (Tinneberg et al . 1985; Wilcox et al .…”

mentioning

confidence: 99%

Previous miscarriage and stillbirth as risk factors for other unfavourable outcomes in the next pregnancy

Paz

Otaño

Gadow

et al. 1992

BJOG

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Objective To look for associations between previous fetal loss and fetal malformation or low birthweight in a subsequent pregnancy. Design A cas‐ontrol study with place of birth, time and sex matched controls. Setting 72 South American maternity hospitals. Subjects 18 534 malformed, 1150 no‐alformed babies of low birthweight and 16 394 controls. All babies were from mothers with at least one previous pregnancy. Main outcome measures Frequency of stillbirths and miscarriages in the previous pregnancy and outcome of the index pregnancy. Results Multiple malformation, Down's syndrome, anencephaly, spina bifida, pes equinovarus, congenital dislocation of the hip and low birthweight are associated with previous fetal loss. Conclusion A miscarriage or a stillbirth in a previous pregnancy should be taken into account when the risk of malformations or low birthweight in a subsequent pregnancy is assessed.

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“…Most conceptions are lost during the preclinical stage of gestation and the women are unaware they have occurred (Tinneberg et al . 1985; Wilcox et al .…”

mentioning

confidence: 99%

Previous miscarriage and stillbirth as risk factors for other unfavourable outcomes in the next pregnancy

Paz

Otaño

Gadow

et al. 1992

BJOG

View full text Add to dashboard Cite

show abstract

Human early pregnancy factor: serum concentrations before and after therapeutic abortion in comparison with ?-hCG and an early pregnancy associated protein

Straube

Hübel

Loh

et al. 1989

Arch Gynecol Obstet

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Serum concentrations of the early pregnancy factor (EPF), beta-hCG and the early pregnancy associated protein (EPAP) were measured in 12 patients before and after therapeutic abortion for social-medical reasons. Detection of EPF was performed by the rosette-inhibition assay, beta-hCG quantification by radioimmunoassay and EPAP measurements by rocket immunoelectrophoresis using a monospecific polyclonal rabbit antiserum. The disappearance rate of EPF after termination of pregnancy was closely correlated with the decrease of beta-hCG concentrations (rpbis = 0.71) and loosely correlated with the decrease of EPAP concentrations (rPbis = 0.43). No correlation has been found between hCG and EPAP values.

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Effects of EPF treatment in human mononuclear cells

Hanf¹,

Oettling

Roberts

et al. 1991

Journal of Reproductive Immunology

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Use of a Modified Test System to Determine Early Pregnancy Factor (EPF) Levels in Patients with Normal First Trimester Pregnancy and after Therapeutic Abortion

Cited by 4 publications

References 6 publications

Previous miscarriage and stillbirth as risk factors for other unfavourable outcomes in the next pregnancy

Previous miscarriage and stillbirth as risk factors for other unfavourable outcomes in the next pregnancy

Human early pregnancy factor: serum concentrations before and after therapeutic abortion in comparison with ?-hCG and an early pregnancy associated protein

Effects of EPF treatment in human mononuclear cells

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